US4348375A
Expired / Lapsed
US
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Radioassay process and compositions useful therein
Assignee: MAALLINCKRODT DIAGNOSTICA (HOLLAND) BV WESTERDUINWEG 3 1755 LE PETTEN NETHERLANDS
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Filing: 1979-12-31
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Granted: 1982-09-07
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Expires: 1999-12-31
Abstract
Abstract There are disclosed aqueous, radioassaying solutions of a chelate of radioactive indium and an 8-hydroxyquinoline, having an essential absence of an organic solvent, e.g., alcohol or chloroform. The solutions are useful in radioassaying warmblooded animals.
Inventors
- 👤 Wilhelmus T. Goedemans
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 07:30
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1203; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K2123/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
65 words
A method for radioassaying a warmblooded animal which comprises administering to said animal an essentially organic solvent-free, aqueous solution containing a small amount of a radioactive indium-8-hydroxyquinoline or blood cells radioactivity labeled by said solution, said amount being sufficient for detection by external imaging, and subjecting said animal to external imaging for detecting accumulated radioactivity to determine its location in the body of said animal.
Claim 2
Independent Claim
65 words
A method for radioassaying a warmblooded animal which comprises administering to said animal an essentially organic solvent-free, aqueous solution containing a small amount of a radioactive indium-8-hydroxyquinoline or blood cells radioactivity labeled by said solution, said amount being sufficient for detection by external imaging, and subjecting said animal to external imaging for detecting accumulated radioactivity to determine its location in the body of said animal.
Claim 3
Dependent Claim
12 words
A method of claim 1 in which said animal is a mammal.
Claim 4
Dependent Claim
22 words
A method of claim 1 or 2 in which said animal has an inflamed area, the location of which is thereby detected.
Claim 5
Dependent Claim
14 words
A method of claim 1 or 2 in which the radioactive material is indium-111-8-hydroxyquinoline.
Claim 6
Dependent Claim
20 words
A method of claim 4 in which said animal has an inflamed area, the location of which is thereby detected.
Claim 7
Dependent Claim
26 words
A method of claim 1 or 2 in which the radioactive material administered to said animal contains about 0.02 to 10 millicuries of radioactivity per milliliter.
Claim 8
Dependent Claim
20 words
A method of claim 6 in which said animal has an inflamed area, the location of which is thereby detected.
Claim 9
Dependent Claim
23 words
An aqueous solution containing a small amount of a radioactive indium-8-hydroxyquinoline suitable for use in radioassaying and being essentially free of organic solvent.
Claim 10
Dependent Claim
23 words
An aqueous solution containing a small amount of a radioactive indium-8-hydroxyquinoline suitable for use in radioassaying and being essentially free of organic solvent.
Claim 11
Dependent Claim
12 words
A solution of claim 8 in which the radioactive material is indium-111-8-hydroxyquinoline.
Claim 12
Dependent Claim
24 words
A solution of claim 8 or 9 in which the amount of indium-8-hydroxyquinoline as an oxine is about 0.005 to 0.2 milligram per milliliter.
Claim 13
Dependent Claim
22 words
A solution of claim 8 or 9 which contains a small amount of sodium chloride sufficient for the solution to be isotonic.
Claim 14
Dependent Claim
19 words
A solution of claim 11 in which the amount of sodium chloride is about 0.1 to 1 weight percent.
Claim 15
Dependent Claim
22 words
A solution of claim 12 in which the amount of indium-8-hydroxyquinoline as an oxine is about 0.005 to 0.2 milligram per milliliter.
References Cited (Backward Citations)
US4017596A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-09-06 | 1986-03-08 | 1986-09-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-09-06 | 1990-03-08 | 1990-09-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-09-06 | 1994-03-08 | 1994-09-07 | $7700.00 | Window Closed / Lapsed |