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US4347245A
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Spironolactone-containing composition and use thereof
Assignee: Individual
•
Filing: 1981-05-26
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Granted: 1982-08-31
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Expires: 2001-05-26
Abstract
Abstract A composition containing spironolactone in an amount effective to suppress excess androgenic activity. The spironolactone-containing composition is applied directly to the skin site afflicted with excess androgens.
Inventors
- 👤 German Shapiro
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 17:37
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/58; A61K31/585
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
74 words
A composition for effectively suppressing excess androgenic activity which occurs at a skin site so as to effectively treat hirsuitisum, said composition being directly applied to said skin site, the composition consisting essentially of: a liquid carrier selected from the group consisting of alcohol, urea, mineral oil and white petrolatum; and spironolactone in an amount of from about 0.25 wt% to about 5.0 wt% which effectively suppresses excess androgenic activity at said skin site.
Claim 2
Dependent Claim
74 words
A composition for effectively suppressing excess androgenic activity which occurs at a skin site so as to effectively treat hirsuitisum, said composition being directly applied to said skin site, the composition consisting essentially of: a liquid carrier selected from the group consisting of alcohol, urea, mineral oil and white petrolatum; and spironolactone in an amount of from about 0.25 wt% to about 5.0 wt% which effectively suppresses excess androgenic activity at said skin site.
Claim 3
Dependent Claim
12 words
The composition of claim 1 wherein said liquid carrier is white petrolatum.
Claim 4
Dependent Claim
51 words
The composition of claim 1 further consisting essentially of: a solubilizer selected from the group consisting of stearyl alcohol, cetyl alcohol or mixtures thereof, said solubilizer being present in an amount of from about 1.5 wt% to about 3.0 wt% so as to aid incorporation of said spironolactone into said carrier.
Claim 5
Dependent Claim
25 words
The composition of claim 3 further consisting essentially of a viscosifier in an amount sufficient to aid in emulsification of said solubilizer in said carrier.
Claim 6
Dependent Claim
38 words
The composition of claim 1 further consisting essentially of: a preservative selected from the group consisting of methylhydroxybenzoate, propylhydroxybenzoate, or mixtures thereof, said preservative being employed in an amount sufficient to extend the useful like of said composition.
Claim 7
Dependent Claim
83 words
In a process for treating at least one skin site characterized by excess androgenic activity so as to effectively suppress said excess androgenic activity, the improvement comprising: directly applying a spironolactone-containing composition to said at least one skin site, said composition consisting essentially of a liquid carrier selected from the group consisting of alcohol, urea, mineral oil and white petroleum and spironolactone in an amount of from about 0.25 wt% to about 5.0 wt% which effectively suppresses androgenic activity at said skin site.
Claim 8
Dependent Claim
83 words
In a process for treating at least one skin site characterized by excess androgenic activity so as to effectively suppress said excess androgenic activity, the improvement comprising: directly applying a spironolactone-containing composition to said at least one skin site, said composition consisting essentially of a liquid carrier selected from the group consisting of alcohol, urea, mineral oil and white petroleum and spironolactone in an amount of from about 0.25 wt% to about 5.0 wt% which effectively suppresses androgenic activity at said skin site.
Claim 9
Dependent Claim
12 words
The process of claim 6 wherein said liquid carier is white petrolatum.
Claim 10
Dependent Claim
54 words
The process of claim 6 wherein said composition further consists essentially of a solubilizer selected from the group consisting of stearyl alcohol, cetyl alcohol or mixtures thereof, said solubilizer being present in an amount of from about 1.5 wt% to about 3.0 wt% so as to aid incorporation of said spironolactone into said carrier.
Claim 11
Dependent Claim
28 words
The process of claim 8 wherein said composition further consists essentially of a viscosifier in an amount sufficient to aid in emulsification of said solubilizer in said carrier.
Claim 12
Dependent Claim
41 words
The process of claim 6 wherein said composition further consists essentially of a preservative selected from the group consisting of methylhydroxybenzoate, propylhydroxybenzoate, or mixtures thereof, said preservative being employed in an amount sufficient to extend the useful life of said composition.
References Cited (Backward Citations)
US3257390A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-08-30 | 1986-03-01 | 1986-08-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-08-30 | 1990-03-01 | 1990-08-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-08-30 | 1994-03-01 | 1994-08-31 | $7700.00 | Window Closed / Lapsed |