Spironolactone-containing composition and use thereof

Claim 2

A composition for effectively suppressing excess androgenic activity which occurs at a skin site so as to effectively treat hirsuitisum, said composition being directly applied to said skin site, the composition consisting essentially of: a liquid carrier selected from the group consisting of alcohol, urea, mineral oil and white petrolatum; and spironolactone in an amount of from about 0.25 wt% to about 5.0 wt% which effectively suppresses excess androgenic activity at said skin site.

Claim 3

The composition of claim 1 wherein said liquid carrier is white petrolatum.

Claim 4

The composition of claim 1 further consisting essentially of: a solubilizer selected from the group consisting of stearyl alcohol, cetyl alcohol or mixtures thereof, said solubilizer being present in an amount of from about 1.5 wt% to about 3.0 wt% so as to aid incorporation of said spironolactone into said carrier.

Claim 5

The composition of claim 3 further consisting essentially of a viscosifier in an amount sufficient to aid in emulsification of said solubilizer in said carrier.

Claim 6

The composition of claim 1 further consisting essentially of: a preservative selected from the group consisting of methylhydroxybenzoate, propylhydroxybenzoate, or mixtures thereof, said preservative being employed in an amount sufficient to extend the useful like of said composition.

Claim 7

In a process for treating at least one skin site characterized by excess androgenic activity so as to effectively suppress said excess androgenic activity, the improvement comprising: directly applying a spironolactone-containing composition to said at least one skin site, said composition consisting essentially of a liquid carrier selected from the group consisting of alcohol, urea, mineral oil and white petroleum and spironolactone in an amount of from about 0.25 wt% to about 5.0 wt% which effectively suppresses androgenic activity at said skin site.

Claim 8

In a process for treating at least one skin site characterized by excess androgenic activity so as to effectively suppress said excess androgenic activity, the improvement comprising: directly applying a spironolactone-containing composition to said at least one skin site, said composition consisting essentially of a liquid carrier selected from the group consisting of alcohol, urea, mineral oil and white petroleum and spironolactone in an amount of from about 0.25 wt% to about 5.0 wt% which effectively suppresses androgenic activity at said skin site.

Claim 9

The process of claim 6 wherein said liquid carier is white petrolatum.

Claim 10

The process of claim 6 wherein said composition further consists essentially of a solubilizer selected from the group consisting of stearyl alcohol, cetyl alcohol or mixtures thereof, said solubilizer being present in an amount of from about 1.5 wt% to about 3.0 wt% so as to aid incorporation of said spironolactone into said carrier.

Claim 11

The process of claim 8 wherein said composition further consists essentially of a viscosifier in an amount sufficient to aid in emulsification of said solubilizer in said carrier.

Claim 12

The process of claim 6 wherein said composition further consists essentially of a preservative selected from the group consisting of methylhydroxybenzoate, propylhydroxybenzoate, or mixtures thereof, said preservative being employed in an amount sufficient to extend the useful life of said composition.