Patent US4346168A successfully refreshed from Google Patents.
US4346168A
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Process for the preparation of penicillin derivatives
Assignee: Beecham Group PLC
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Filing: 1980-05-13
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Granted: 1982-08-24
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Expires: 2000-05-13
Abstract
Abstract A process for the preparation of α-carboxy, 6, α-methoxy penicillin derivatives by the enzymatic hydrolysis of an esterified derivative. The process is for the preparation of a compound of formula (I): ##STR1## wherein R represents phenyl or 2- or 3-thienyl, which process comprises subjecting a compound of formula (IV): ##STR2## wherein R 1 is an ester-forming radical, to the action of the enzyme α-chymotrypsin or an esterase-producing strain of Streptomyces sp.
Inventors
- 👤 Martin Cole
- 👤 Robert A. Edmondson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:46
CPC Classifications
C; C07; C07D; C07D499/00; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12N9/00; C12N9/14; C12N9/16; C12N9/18; C12P; C12P37/00; C12R; C12R2001/00; C12R2001/01; C12R2001/465; C12R2001/58
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
52 words
A process for the preparation of a 6α-methoxy penicillin of formula (I): ##STR8## wherein R represents phenyl or 2- or 3-thienyl, which process comprises subjecting a compound of formula (IV): ##STR9## where R 1 is an ester-forming radical, to the action of the enzyme α-chymotrypsin or an esterase-producing strain of Streptomyces sp.
Claim 2
Dependent Claim
52 words
A process for the preparation of a 6α-methoxy penicillin of formula (I): ##STR8## wherein R represents phenyl or 2- or 3-thienyl, which process comprises subjecting a compound of formula (IV): ##STR9## where R 1 is an ester-forming radical, to the action of the enzyme α-chymotrypsin or an esterase-producing strain of Streptomyces sp.
Claim 3
Dependent Claim
19 words
A process as claimed in claim 1 wherein R 1 is an optionally substituted alkyl, aryl or aralkyl group.
Claim 4
Dependent Claim
24 words
A process as claimed in claim 1 wherein R 1 is C 1-6 alkyl, phenyl or mono-, di-, or tri-(C 1-6 )-alkyl substituted phenyl.
Claim 5
Dependent Claim
11 words
A process as claimed in claim 1 wherein R represents 3-thienyl.
Claim 6
Dependent Claim
24 words
A process as claimed in claim 1, wherein the esterase-producing strain of Streptomyces sp. is Streptomyces olivaceus ATCC 3335 or Streptomyces clavuligerus ATCC 27064.
Claim 7
Dependent Claim
16 words
A process as claimed in claim 1, wherein the esterase-producing strain is Streptomyces olivaceus ATCC 3335.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-08-23 | 1986-02-22 | 1986-08-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-08-23 | 1990-02-22 | 1990-08-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-08-23 | 1994-02-22 | 1994-08-24 | $7700.00 | Window Closed / Lapsed |