US4340565A
Expired / Lapsed
US
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Hematocrit value determining element
Assignee: Fujifilm Holdings Corp
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Filing: 1980-12-29
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Granted: 1982-07-20
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Expires: 2000-12-29
Abstract
Abstract A hematocrit value determining element comprising, in one embodiment, a water-impermeable planar support having integrally provided thereon a hydrophilic porous spreading layer, the porous spreading layer being such that blood spreads therethrough depending upon the viscosity of the blood and, in a second embodiment, a hematocrit value determining element as described above and a binder layer provided between the planar support and the porous spreading layer.
Inventors
- 👤 Masao Kitajima
- 👤 Fuminori Arai
- 👤 Asaji Kondo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 13:30
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/525
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
107 words
A hematocrit value determining element comprising a water-impermeable planar support having integrally provided thereon a porous spreading layer which has a hydrophilic surface and in which the surface of the internal voids or the interior is hydrophilic and water-insoluble, said porous spreading layer being such that blood spreads therethrough depending upon the spreading nature of the blood, wherein the porous spreading layer has a mean pore diameter ranging from about 0.1 μm to about 2.5 μm and wherein the porous spreading layer comprises a layer of a non-fibrous porous material or a fibrous porous material which has a yarn number count of about 100 to about 200.
Claim 2
Dependent Claim
107 words
A hematocrit value determining element comprising a water-impermeable planar support having integrally provided thereon a porous spreading layer which has a hydrophilic surface and in which the surface of the internal voids or the interior is hydrophilic and water-insoluble, said porous spreading layer being such that blood spreads therethrough depending upon the spreading nature of the blood, wherein the porous spreading layer has a mean pore diameter ranging from about 0.1 μm to about 2.5 μm and wherein the porous spreading layer comprises a layer of a non-fibrous porous material or a fibrous porous material which has a yarn number count of about 100 to about 200.
Claim 3
Dependent Claim
18 words
The hematocrit value determining element as claimed in claim 1, wherein the hydrophilic porous spreading layer is water-insoluble.
Claim 4
Dependent Claim
17 words
The hematocrit value determining element as claimed in claim 1, wherein said water-impermeable planar support is transparent.
Claim 5
Dependent Claim
28 words
The hematocrit value determining element as claimed in claim 1, wherein said water-impermeable planar support is a support of metal, wood, paper, glass or a synthetic resin film.
Claim 6
Dependent Claim
35 words
The hematocrit value determining element as claimed in claim 1, wherein said mean pore diameter is from about 0.4 μm to about 2 μm and said yarn number count is about 120 to about 160.
Claim 7
Dependent Claim
29 words
The hematocrit value determining element as claimed in claim 1, wherein the hydrophilic porous spreading layer comprises a layer of a non-fibrous porous material or a fibrous porous material.
Claim 8
Dependent Claim
19 words
The hematocrit value determining element as claimed in claim 6, wherein the non-fibrous porous material comprises a porous membrane.
Claim 9
Dependent Claim
22 words
The hematocrit value determining element as claimed in claim 6, wherein said fibrous porous material is glass fiber, a fabric or paper.
Claim 10
Dependent Claim
23 words
The hematocrit value determining element as claimed in claim 1, which consists essentially of said water-impermeable planar support and said porous spreading layer.
Claim 11
Dependent Claim
45 words
The hematocrit value determining element as claimed in claim 9, wherein said porous spreading layer further contains at least one member selected from the group consisting of a pH buffer, an anticoagulant, an antihemolytic agent, an antioxidant, an oxidizing agent and an erythrocyte membrane-modifying agent.
Claim 12
Dependent Claim
36 words
The hematocrit value determining element as claimed in claim 10, wherein said erythrocyte membrane-modifying agent is selected from the groups consisting of a dye, a pigment, an inorganic salt, an aldehyde, an isocyanate and hydrogen peroxide.
Claim 13
Dependent Claim
25 words
The hematocrit value determining element as claimed in claim 1, wherein a binder layer is provided between said planar support and said porous spreading layer.
Claim 14
Dependent Claim
21 words
The hematocrit value determining element as claimed in claim 12, wherein said binder layer is a layer of a hydrophilic binder.
Claim 15
Dependent Claim
40 words
The hematocrit value determining element as claimed in claim 12, wherein said binder layer uniformly adheres the porous layer to the support in a fluid contact state and controls the spreading of a blood sample through the porous spreading layer.
Claim 16
Dependent Claim
45 words
The hematocrit value determining element as claimed in claim 12, wherein said binder layer contains a pH indicator which becomes colored or discolored depending upon the pH of blood serum or a color reagent which reacts with a blood serum ingredient to produce a color.
Claim 17
Dependent Claim
50 words
The hematocrit value determining element of claim 12, wherein said binder layer is formed of a hydrophobic binder or a hydrophilic binder selected from the group consisting of polyvinyl acetate, polystyrene, polymethyl methacrylate, vinyl chloride-vinyl acetate copolymers, cellulose esters, polyurethanes, melamine, gelatin, agarose, dextran, polyvinyl alcohol, polyacrylamide and polyacrylic acid.
Claim 18
Dependent Claim
51 words
The hematocrit value determining element as claimed in claim 16, wherein said binder layer contains at least one additive selected from the group consisting of nonionic, cationic or anionic surfactants, plasticizers, inorganic salts, organic acid salts, pH buffers, pigments, dyes, solid fine particulate fibers, oxidizing agents, reducing agents, acids and alkalis.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-07-19 | 1986-01-18 | 1986-07-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-07-19 | 1990-01-18 | 1990-07-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-07-19 | 1994-01-18 | 1994-07-20 | $7700.00 | Window Closed / Lapsed |