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US4338435A
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Benzothiadiazines having diuretic activity
Assignee: ER Squibb and Sons LLC
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Filing: 1981-06-01
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Granted: 1982-07-06
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Expires: 2001-06-01
Abstract
Abstract Compounds having the formula ##STR1## wherein R 1 and R 2 are each independently hydrogen, halogen, trifluoromethyl, aminosulfonyl, nitro, alkyl or alkoxy; R 3 is hydrogen, alkyl, or phenylmethyl; R 4 is hydrogen, alkyl, or phenyl, and R 15 is alkyl, phenyl or phenylmethyl, or R 4 and R 15 together are --(CH 2 ) m -- wherein m is 1 or 2; R 5 ,R 6 ,R 7 ,R 8 ,R 9 ,R 10 ,R 11 ,R 12 ,R 13 and R 14 are each independently hydrogen, halogen, alkyl or phenyl; n 1 ,n 2 ,n 3 ,n 4 and n 5 are each independently 0 or 1; with the proviso that if R 4 and R 15 together are --(CH 2 ) m -- the sum of n 1 , n 2 , n 3 , n 4 , n 5 and m is 2 or 3; have diuretic activity.
Inventors
- 👤 Rudiger D. Haugwitz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:13
CPC Classifications
C; C07; C07D; C07D285/00; C07D285/15; C07D285/16; C07D285/18; C07D285/20; C07D285/22; C07D285/24; C07D285/26; C07D285/30; C07C; C07C327/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
162 words
A compound having the formula ##STR10## wherein R 1 and R 2 are each independently hydrogen, halogen, trifluoromethyl, aminosulfonyl, nitro, alkyl or alkoxy; R 3 is hydrogen, alkyl, or phenylmethyl; R 4 is hydrogen, alkyl, or phenyl, and R 15 is alkyl, phenyl or phenylmethyl, or R 4 and R 15 together are --(CH 2 ) m -- wherein m is 1 or 2; R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 and R 14 are each independently hydrogen, halogen, alkyl or phenyl; n 1 , n 2 , n 3 , n 4 , and n 5 are each independently O or 1; with the proviso that if R 4 and R 15 together are --(CH 2 ) m --, the sum of n 1 , n 2 , n 3 , n 4 , n 5 and m is 2 or 3.
Claim 2
Dependent Claim
162 words
A compound having the formula ##STR10## wherein R 1 and R 2 are each independently hydrogen, halogen, trifluoromethyl, aminosulfonyl, nitro, alkyl or alkoxy; R 3 is hydrogen, alkyl, or phenylmethyl; R 4 is hydrogen, alkyl, or phenyl, and R 15 is alkyl, phenyl or phenylmethyl, or R 4 and R 15 together are --(CH 2 ) m -- wherein m is 1 or 2; R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 and R 14 are each independently hydrogen, halogen, alkyl or phenyl; n 1 , n 2 , n 3 , n 4 , and n 5 are each independently O or 1; with the proviso that if R 4 and R 15 together are --(CH 2 ) m --, the sum of n 1 , n 2 , n 3 , n 4 , n 5 and m is 2 or 3.
Claim 3
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 1 is aminosulfonyl.
Claim 4
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 3 is hydrogen.
Claim 5
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 4 is hydrogen.
Claim 6
Dependent Claim
15 words
A compound in accordance with claim 1 wherein n 4 and n 5 are O.
Claim 7
Dependent Claim
11 words
A compound in accordance with claim 1 having the formula ##STR11##
Claim 8
Dependent Claim
11 words
A compound in accordance with claim 6 having the formula ##STR12##
Claim 9
Dependent Claim
9 words
The compound in accordance with claim 1, 3-[2-(acetylthio)ethyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide.
Claim 10
Dependent Claim
9 words
The compound in accordance with claim 1, 3-[2-(acetylthio)ethyl]-3-methyl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1985-07-05 | 1986-01-04 | 1986-07-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-07-05 | 1990-01-04 | 1990-07-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-07-05 | 1994-01-04 | 1994-07-06 | $7700.00 | Window Closed / Lapsed |