US4337314A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Genetically attenuated bacterial vaccines with multiple mutations of the same phenotype
Assignee: RESEARCH Corp A NOT-FOR-PROFIT CORP OF NY
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Filing: 1979-05-23
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Granted: 1982-06-29
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Expires: 1999-05-23
Abstract
Abstract A vaccine composition comprising a genetically attenuated bacterial strain which contains at least two mutations of the same phenotype which strain is rendered avirulent while retaining immunogenicity.
Inventors
- 👤 Max P. Oeschger
- 👤 Anne M. Hooke
- 👤 Joseph A. Bellanti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 21:44
CPC Classifications
C; C12; C12N; C12N1/00; C12N1/20; C12N1/205; A; A61; A61K; A61K39/00; A61K39/02; A61K39/102; C12N15/00; A61K2039/51; A61K2039/52; A61K2039/522; C12R; C12R2001/00; C12R2001/01; C12R2001/21; Y; Y10; Y10S; Y10S424/00; Y10S424/83; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/851
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
74 words
A biologically pure culture of an avirulent bacterial strain useful as a vaccine, wherein said avirulent strain is derived from a virulent bacterial strain by introducing into said virulent strain at least two mutations of the same phenotype which render said virulent strain avirulent, while permitting said avirulent strain to retain immunogenicity; wherein said phenotype is a temperature-sensitive phenotype which suppresses growth at the normal body temperature of a host for said virulent strain.
Claim 2
Dependent Claim
74 words
A biologically pure culture of an avirulent bacterial strain useful as a vaccine, wherein said avirulent strain is derived from a virulent bacterial strain by introducing into said virulent strain at least two mutations of the same phenotype which render said virulent strain avirulent, while permitting said avirulent strain to retain immunogenicity; wherein said phenotype is a temperature-sensitive phenotype which suppresses growth at the normal body temperature of a host for said virulent strain.
Claim 3
Dependent Claim
14 words
The avirulent strain of any of claim 1 wherein said bacterium is H. influenzae.
Claim 4
Dependent Claim
13 words
The avirulent strain of claim 2 wherein said bacterium is H. influenzae A214-A/3.
Claim 5
Dependent Claim
13 words
The avirulent strain of claim 2 wherein said bacterium is H. influenzae A214-A/3-C2/13.
Claim 6
Dependent Claim
20 words
The strain of any of claim 1 wherein said avirulent strain contains at least three mutations of the same phenotype.
Claim 7
Dependent Claim
32 words
The strain of any of claim 1 wherein said phenotype is such that growth will occur for at most 7 cell divisions after contact with the normal body temperature of said host.
Claim 8
Dependent Claim
25 words
The strain of claim 6 wherein growth will occur for at most 3 cell divisions after contact with the normal body temperature of said host.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-28 | 1985-12-28 | 1986-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-28 | 1989-12-28 | 1990-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-28 | 1993-12-28 | 1994-06-29 | $7700.00 | Window Closed / Lapsed |