Patent US4336161A successfully refreshed from Google Patents.
US4336161A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composite materials comprising deformable xerogel within the pores of particulate rigid supports useful in chromatography
Assignee: Ricardo AEA Ltd
•
Filing: 1979-10-16
•
Granted: 1982-06-22
•
Expires: 1999-10-16
Abstract
Abstract The invention discloses a composite material comprising a deformable gel retained within the pores of a porous rigid support material. The deformable gel comprises an affinity chromatography agent such that the composite material has affinity chromatography properties.
Inventors
- 👤 Alan Rosevear
- 👤 Patrick Mattock
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 00:11
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/281; B01J20/291; B01D; B01D15/00; B01D15/08; B01D57/00; B01D57/02; B01J20/02; B01J20/10; B01J20/14; B01J20/22; B01J20/26; B01J20/261; B01J20/262; B01J20/264; B01J20/265; B01J20/267; B01J20/28; B01J20/28014; B01J20/28016; B01J20/28047; B01J20/28054; B01J20/28095; B01J20/28097; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3248; B01J20/3251; B01J20/3253; B01J20/3255; B01J20/3268; B01J20/327; B01J20/3272; B01J20/3274; B01J20/3276; B01J20/328; B01J20/3282; B01J43/00; B01J47/00; B01J47/018; G; G01; G01N; G01N27/00; G01N27/26; G01N27/416; G01N27/447; G01N27/44704; G01N27/44747; B01D15/26; B01D15/36; B01D15/361; B01D15/364; B01J2220/00; B01J2220/40; B01J2220/49; B01J2220/50; B01J2220/54; B01J2220/58; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/811; Y10S530/812; Y10S530/813; Y10S530/814; Y10S530/815
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
49 words
A particulate material comprising a plurality of discrete porous rigid support particles, and a deformable xerogel retained within and substantially filling the pore structure of the support particles, said deformable xerogel comprising an affinity chromatography agent such that the particulate material is a composite material having affinity chromatography properties.
Claim 2
Dependent Claim
49 words
A particulate material comprising a plurality of discrete porous rigid support particles, and a deformable xerogel retained within and substantially filling the pore structure of the support particles, said deformable xerogel comprising an affinity chromatography agent such that the particulate material is a composite material having affinity chromatography properties.
Claim 3
Dependent Claim
29 words
A particulate material according to claim 1 wherein said affinity chromatography agent comprises a group specific ligand capable of interacting specifically with the nucleotide binding sites of an enzyme.
Claim 4
Dependent Claim
22 words
A particulate material according to claim 1 wherein said affinity chromatography agent comprises a ligand capable of retaining proteins from human plasma.
Claim 5
Dependent Claim
20 words
A particulate material according to claim 1 wherein said deformable xerogel comprises a polysaccharide gel or a synthetic polymer gel.
Claim 6
Dependent Claim
19 words
A particulate material according to claim 4 wherein said polysaccharide gel is an agarose gel or a cellulose gel.
Claim 7
Dependent Claim
24 words
A particulate material according to claim 4 wherein said synthetic polymer gel is a polymer of an acrylate or a polyvinyl alcohol polymer gel.
Claim 8
Independent Claim
101 words
A method for preparing a particulate material comprising a deformable xerogel retained in the pore structure of a particulate porous rigid support material which comprises introducing a precursor for the xerogel into the pore structure of a plurality of discrete particles of porous rigid support material such that the gel precursor fills the pores of the discrete particles, and effecting gelation of the precursor within the discrete particles to form a plurality of discrete porous rigid support particles having a deformable xerogel retained within and substantially filling the pore structure of the support particles, said deformable xerogel having affinity chromatography properties.
Claim 9
Independent Claim
101 words
A method for preparing a particulate material comprising a deformable xerogel retained in the pore structure of a particulate porous rigid support material which comprises introducing a precursor for the xerogel into the pore structure of a plurality of discrete particles of porous rigid support material such that the gel precursor fills the pores of the discrete particles, and effecting gelation of the precursor within the discrete particles to form a plurality of discrete porous rigid support particles having a deformable xerogel retained within and substantially filling the pore structure of the support particles, said deformable xerogel having affinity chromatography properties.
Claim 10
Independent Claim
117 words
A method for preparing a particulate material comprising a deformable xerogel retained in the pore structure of a particulate porous rigid support material which comprises introducing a precursor for the xerogel into the pore structure of a plurality of discrete particles of porous rigid support material such that the gel precursor fills the pores of the discrete particles, and effecting gelation of the precursor within the discrete particles to form a plurality of discrete porous rigid support particles having a deformable xerogel retained within and substantially filling the pore structure of the support particles, and treating the deformable xerogel retained within the pores of said rigid support material to impart affinity chromatography properties to the deformable xerogel.
Claim 11
Independent Claim
117 words
A method for preparing a particulate material comprising a deformable xerogel retained in the pore structure of a particulate porous rigid support material which comprises introducing a precursor for the xerogel into the pore structure of a plurality of discrete particles of porous rigid support material such that the gel precursor fills the pores of the discrete particles, and effecting gelation of the precursor within the discrete particles to form a plurality of discrete porous rigid support particles having a deformable xerogel retained within and substantially filling the pore structure of the support particles, and treating the deformable xerogel retained within the pores of said rigid support material to impart affinity chromatography properties to the deformable xerogel.
Claim 12
Dependent Claim
20 words
A method according to claim 8 wherein said treating step comprises coupling an affinity chromatography ligand to the deformable xerogel.
References Cited (Backward Citations)
US3442819A
Cited
US3403109A
Cited
US3943072A
Cited
US3941718A
Cited
US3922432A
Cited
US3960720A
Cited
US4016149A
Cited
US3947352A
Cited
US3954678A
Cited
US4000098A
Cited
US4045353A
Cited
GB1537086A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-21 | 1985-12-21 | 1986-06-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-21 | 1989-12-21 | 1990-06-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-21 | 1993-12-21 | 1994-06-22 | $7700.00 | Window Closed / Lapsed |