1-[3-(3,4,5-Trimethoxyphenoxy)-2-hydroxy-propyl]-4-aryl-piperazine-derivatives having pharmaceutical activity

Abstract

Abstract There are prepared compounds corresponding to the general formula ##STR1## in which R 1 is a hydrogen atom, a C 2 to C 6 -alkanoyl group, a C 3 to C 6 -alkenoyl group, a C 3 to C 6 -cycloalkyl carbonyl group, a benzoyl group, an alkoxybenzoyl group, a nicotinoyl group, a thienyl carbonyl group, a furyl carbonyl group, a phenylacetyl group or a C 1 to C 4 -alkoxyphenyl acetyl group and R 2 represents a phenyl, naphthyl or pyridyl group or such group substituted by the groups R 3 and R 4 , the groups R 3 and R 4 , which may be the same or different, each representing hydrogen, hydroxyl, fluorine, chlorine, bromine, a nitro group, a trifluoromethyl group, a C 1 to C 6 -alkyl group, a C 1 to C 6 -alkoxy group, a C 1 to C 6 -alkyl thio group, a C 1 to C 6 -alkyl sulphonyl group, a C 2 to C 6 -alkanoyl group, an amino group, an acylamino group or an acyloxy group in which the acyl is of the type defined in respect to R 1 , and their salts. The compounds are pharmacodynamically active.

Inventors

• 👤 Axel Kleemann
• 👤 Vladimir Jakovlev
• 👤 Klaus Thiemer
• 👤 Jurgen Engel

Bibliographic Details