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US4335100A
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Method of inhibiting dextransucrase and oral compositions for use therein
Assignee: Iowa State University Research Foundation Inc
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Filing: 1980-08-06
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Granted: 1982-06-15
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Expires: 2000-08-06
Abstract
Abstract Dextransucrase synthesis of dextran from sucrose is inhibited by substituted sucrose compounds which have an inhibiting group bonded to the 5-position ring carbon. Oral compositions containing such substituted sucrose compounds can be used to control dextran formation in the mouth, and dextran comprises the principal component of dental plaque.
Inventors
- 👤 John F. Robyt
- 👤 John N. Zikopoulos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 19:05
CPC Classifications
C; C07; C07H; C07H11/00; A; A23; A23G; A23G3/00; A23G3/34; A23G3/346; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/60; A61K8/69; A61Q; A61Q11/00; C07H3/00; C07H3/08; C07H5/00; C07H5/02; C07H5/04; C07H5/06; A23G2200/00; A23G2200/06; A61K2800/00; A61K2800/74; A61K2800/78; A61K2800/782
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
78 words
The method of inhibiting dextransucrase synthesis of dextran from sucrose, comprising introducing into an aqueous substrate containing sucrose and dextransucrase an inhibitory amount of a substituted sucrose compound, said substituted sucrose compound having bonded to the 5-position ring carbon a group selected from the class consisting of --CH 2 X, ═CH 2 , --CHO, and --H, wherein X is selected from the class consisting of --Br, --I, --N 3 , --NH 2 , --OCH 3 , and --H.
Claim 2
Independent Claim
78 words
The method of inhibiting dextransucrase synthesis of dextran from sucrose, comprising introducing into an aqueous substrate containing sucrose and dextransucrase an inhibitory amount of a substituted sucrose compound, said substituted sucrose compound having bonded to the 5-position ring carbon a group selected from the class consisting of --CH 2 X, ═CH 2 , --CHO, and --H, wherein X is selected from the class consisting of --Br, --I, --N 3 , --NH 2 , --OCH 3 , and --H.
Claim 3
Dependent Claim
19 words
The method of claim 1 in which said group bonded to the 5-position ring carbon is --CH 2 I.
Claim 4
Dependent Claim
19 words
The method of claim 1 in which said group bonded on the 5-position ring carbon is --CH 2 Br.
Claim 5
Dependent Claim
28 words
The methods of claim 1 in which said substituted sucrose also has bonded to the 5'-position ring carbon the same group as bonded to the 5-position ring carbon.
Claim 6
Dependent Claim
20 words
The method of claim 1 in which said substituted sucrose is selected from the class consisting of 6,6'-dideoxy-6,6'-dibromosucrose, and 6,6'-dideoxy-6,6'-diiodosucrose.
Claim 7
Dependent Claim
79 words
An oral composition comprising a carrier suitable for use in the oral cavity containing an amount of a substituted sucrose compound effective for inhibiting the dextransucrase synthesis of dextran, said substituted sucrose compound having bonded to the 5-position ring carbon a group selected from the class consisting of --CH 2 X, ═CH 2 , --CHO, and --H, wherein X is selected from the class consisting of --Br, --I, --N 3 , --NH 2 , --OCH 3 , and --H.
Claim 8
Dependent Claim
79 words
An oral composition comprising a carrier suitable for use in the oral cavity containing an amount of a substituted sucrose compound effective for inhibiting the dextransucrase synthesis of dextran, said substituted sucrose compound having bonded to the 5-position ring carbon a group selected from the class consisting of --CH 2 X, ═CH 2 , --CHO, and --H, wherein X is selected from the class consisting of --Br, --I, --N 3 , --NH 2 , --OCH 3 , and --H.
Claim 9
Dependent Claim
20 words
The oral composition of claim 6 in which said group bonded to the 5-position ring carbon is --CH 2 I.
Claim 10
Dependent Claim
20 words
The oral composition of claim 6 in which said group bonded to the 5-position ring carbon is --CH 2 Br.
Claim 11
Dependent Claim
29 words
The oral composition of claim 5 in which said substituted sucrose also has bonded to the 5'-position ring carbon the same group as bonded to the 5-position ring carbon.
Claim 12
Dependent Claim
21 words
The oral composition of claim 5 in which said substituted sucrose is selected from the class consisting of 6,6'-dideoxy-6,6'-dibromosucrose, and 6,6'-dideoxy-6,6'-diiodosucrose.
Claim 13
Dependent Claim
18 words
The oral composition of claims 6, 7, 8, 9 or 10 in which said carrier is a toothpaste.
Claim 14
Dependent Claim
18 words
The oral composition of claims 6, 7, 8, 9 or 10 in which said carrier is a toothpowder.
Claim 15
Dependent Claim
19 words
The oral composition of claims 6, 7, 8, 9 or 10 in which said carrier is a chewing gum.
Claim 16
Dependent Claim
18 words
The oral composition of claims 6, 7, 8, 9 or 10 in which said carrier is a mouthwash.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-14 | 1985-12-14 | 1986-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-14 | 1989-12-14 | 1990-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-14 | 1993-12-14 | 1994-06-15 | $7700.00 | Window Closed / Lapsed |