Patent US2575718A successfully refreshed from Google Patents.
Patent US4334019A successfully refreshed from Google Patents.
US4334019A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for producing de(mycinosyloxy)tylosin
Assignee: Eli Lilly and Co
•
Filing: 1981-05-08
•
Granted: 1982-06-08
•
Expires: 2001-05-08
Abstract
Abstract 23-De(mycinosyloxy)tylosin (DMOT) which has the formula: ##STR1## 20-dihydro-DMOT, specified acyl ester derivatives, and the acid addition salts thereof are useful antibacterial agents. New methods of making 23-deoxy-5-O-mycaminosyltylonolide (DOMT) and 20-dihydro-DOMT by mild acid hydrolysis of DMOT and 20-dihydro-DMOT, respectively, are included.
Inventors
- 👤 Richard H. Baltz
- 👤 Gene M. Wild
- 👤 Eugene T. Seno
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 15:38
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P19/00; C12P19/44; C12P19/60; C12P19/62; C12R; C12R2001/00; C12R2001/01; C12R2001/465; C12R2001/54; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886; Y10S435/896
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
48 words
The method of producing 23-de(mycinosyloxy)tylosin and 20-dihydro-23-de(mycinosyloxy)tylosin which comprises cultivating Streptomyces fradiae NRRL 11271 or a 23-de(mycinosyloxy)tylosin-producing mutant or recombinant thereof in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until a substantial amount of antibiotic activity is produced.
Claim 2
Independent Claim
48 words
The method of producing 23-de(mycinosyloxy)tylosin and 20-dihydro-23-de(mycinosyloxy)tylosin which comprises cultivating Streptomyces fradiae NRRL 11271 or a 23-de(mycinosyloxy)tylosin-producing mutant or recombinant thereof in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until a substantial amount of antibiotic activity is produced.
Claim 3
Dependent Claim
12 words
The method of claim 1 which comprises cultivating Streptomyces fradiae NRRL 11271.
Claim 4
Dependent Claim
15 words
The method of claim 1 or 2 which includes the additional step of isolating 23-de(mycinosyloxy)tylosin.
Claim 5
Dependent Claim
15 words
The method of claim 1 or 2 which includes the additional step of isolating 20-dihydro-23-de(mycinosyloxy)tylosin.
Claim 6
Dependent Claim
16 words
A biologically pure culture of Streptomyces fradiae NRRL 11271 or a 23-de(mycinosyloxy)tylosin-producing mutant or recombinant thereof.
Claim 7
Dependent Claim
16 words
A biologically pure culture of Streptomyces fradiae NRRL 11271 or a 23-de(mycinosyloxy)tylosin-producing mutant or recombinant thereof.
Claim 8
Dependent Claim
16 words
The biologically pure culture of claim 5 wherein the Streptomyces fradiae is Streptomyces fradiae NRRL 11271.
References Cited (Backward Citations)
US3178341A
Cited
US3326759A
Cited
US3344024A
Cited
US3459853A
Cited
US4161523A
Cited
US3923784A
Cited
US3939144A
Cited
US4056616A
Cited
US4196280A
Cited
US4205163A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-07 | 1985-12-07 | 1986-06-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-07 | 1989-12-07 | 1990-06-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-07 | 1993-12-07 | 1994-06-08 | $7700.00 | Window Closed / Lapsed |