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US4332806A
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US
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Antitumor and immunosuppresive 4-carbamoyl imidazolium-5-olate derivatives, pharmaceutical composition and production thereof
Assignee: Sumitomo Chemical Co Ltd
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Filing: 1980-11-12
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Granted: 1982-06-01
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Expires: 2000-11-12
Abstract
Abstract There are provided compounds of the formula: <IMAGE> wherein R is an adamantoyl group substituted with a lower alkyl group, a lower alkoxy group, a hydroxy group, a lower alkanoyloxy group, an aroyloxy group, a halogen atom, an acetamido group, a nitro group, an azide group, a trifluoromethyl group or a phenyl group which may be substituted with a nitro group, a halogen atom, a lower alkyl group or a lower alkoxy group and a process producing them. These compounds are useful as antitumor agents and immunosuppressants.
Inventors
- 👤 Toshio Atsumi
- 👤 Yoshiaki Takebayashi
- 👤 Takao Kiyohara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 12:54
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/66; C07D233/90; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
49 words
A compound of the formula ##STR6## wherein R is adamantoyl substituted with 1-3 substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, lower alkanoyloxy, aroyloxy, halogen, acetamido, nitro, an azide group, trifluoromethyl, or phenyl which may be substituted with nitro, halogen, lower alkyl or lower alkoxy.
Claim 2
Dependent Claim
49 words
A compound of the formula ##STR6## wherein R is adamantoyl substituted with 1-3 substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, lower alkanoyloxy, aroyloxy, halogen, acetamido, nitro, an azide group, trifluoromethyl, or phenyl which may be substituted with nitro, halogen, lower alkyl or lower alkoxy.
Claim 3
Dependent Claim
10 words
A compound according to claim 1, wherein R is 3-fluoroadamantanecarbonyl.
Claim 4
Dependent Claim
10 words
A compound according to claim 1, wherein R is 3-chloroadamantanecarbonyl.
Claim 5
Dependent Claim
10 words
A compound according to claim 1, wherein R is 3-bromoadamantanecarbonyl.
Claim 6
Dependent Claim
10 words
A compound according to claim 1, wherein R is 3-phenyladamantanecarbonyl.
Claim 7
Dependent Claim
10 words
A compound according to claim 1, wherein R is 3,5,7-trimethyladamantanecarbonyl.
Claim 8
Dependent Claim
10 words
A compound according to claim 1, wherein R is 3-methoxyadamantanecarbonyl.
Claim 9
Dependent Claim
26 words
An antitumor composition which comprises an antitumor effective amount of a compound of claim 1 as an active ingredient and a pharmacetically acceptable carrier or diluent.
Claim 10
Dependent Claim
25 words
An immunosuppressant composition which comprises an immunosuppressive amount of a compound of claim 1 as an active ingredient and a pharmaceutically acceptable carrier or diluent.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-31 | 1985-11-30 | 1986-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-31 | 1989-11-30 | 1990-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-31 | 1993-11-30 | 1994-06-01 | $7700.00 | Window Closed / Lapsed |