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US4331808A
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Chemiluminescent naphthalene-1,2-dicarboxylic acid hydrazide-labeled haptens
Assignee: Bayer Corp
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Filing: 1979-10-05
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Granted: 1982-05-25
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Expires: 1999-10-05
Abstract
Abstract Chemiluminescent-labeled conjugates of the formula: <IMAGE> wherein R is hydrogen or straight chain alkyl containing 1-4 carbon atoms, n=2-6 and L(CO- is a specifically bindable ligand, such as an antigenic protein or polypeptide, a hapten or an antibody, or a binding analog thereof, bound through an amide bond; and intermediates produced in the synthesis of such conjugates. The labeled conjugates are useful as reagents in specific binding assays for determining ligands or their specific binding partners in liquid media.
Inventors
- 👤 Robert T. Buckler
- 👤 Hartmut R. Schroeder
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:26
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; C07D237/00; C07D237/26; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/532; G01N33/533; Y; Y10; Y10S; Y10S436/00; Y10S436/822; Y10S530/00; Y10S530/807
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
59 words
A chemiluminescent-labeled conjugate for use in specific binding assays of the general formula: L(CO)(NH)labeling substance wherein L(CO-- is a hapten of molecular weight greater than 100 bound to said labeling substance through an amide bond, characterized in that said --NH)labeling substance has the formula: ##STR21## wherein R is hydrogen or straight chain alkyl containing 1-4 carbon atoms and n=2-6.
Claim 2
Dependent Claim
59 words
A chemiluminescent-labeled conjugate for use in specific binding assays of the general formula: L(CO)(NH)labeling substance wherein L(CO-- is a hapten of molecular weight greater than 100 bound to said labeling substance through an amide bond, characterized in that said --NH)labeling substance has the formula: ##STR21## wherein R is hydrogen or straight chain alkyl containing 1-4 carbon atoms and n=2-6.
Claim 3
Dependent Claim
17 words
The labeled conjugate of claim 1 wherein said hapten has a molecular weight between 100 and 1,500.
Claim 4
Dependent Claim
13 words
The labeled conjugate of claim 1 wherein said hapten is an iodothyronine hormone.
Claim 5
Dependent Claim
11 words
The labeled conjugate of claim 3 wherein said hormone is thyroxine.
Claim 6
Dependent Claim
10 words
The labeled conjugate of any of claims 1-4 wherein n=4.
Claim 7
Dependent Claim
10 words
The labeled conjugate of claim 5 wherein R is ethyl.
Claim 8
Dependent Claim
3 words
7-[N-Ethyl-N-(4-thyroxinylamido)butyl]aminonaphthalene-1,2-dicarboxylic acid hydrazide.
Claim 9
Dependent Claim
3 words
7-[N-Ethyl-N-(4-thyroxinylamido)butyl]aminonaphthalene-1,2-dicarboxylic acid hydrazide.
References Cited (Backward Citations)
BE856189A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-24 | 1985-11-23 | 1986-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-24 | 1989-11-23 | 1990-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-24 | 1993-11-23 | 1994-05-25 | $7700.00 | Window Closed / Lapsed |