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US4331766A
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Collagen solution, process for its manufacture and its use
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1980-07-17
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Granted: 1982-05-25
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Expires: 2000-07-17
Abstract
Abstract Process for the manufacture of a collagen solution and its use for the manufacture of collagen fibrillae for adsorbing coagulation factors, as diagnostic agent, for the manufacture of a collagen sponge and for use in a cosmetic preparation.
Inventors
- 👤 Udo Becker
- 👤 Konrad Braun
- 👤 Norbert Heimburger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 09:21
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/10; C12N9/1025; C12N9/104; C12N9/1044; A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61K8/65; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L15/42; A61L15/425; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; A61P; A61P17/00; A61P7/00; A61P7/04; A61Q; A61Q19/00; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; C07K14/78; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/86; A61K38/00; G01N2333/00; G01N2333/435; G01N2333/745; G01N2333/755; G01N2333/78; G01N2333/90; G01N2333/91; G01N2333/91045; G01N2333/91074; G01N2333/9108; G01N2333/91085
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
66 words
A process for the preparation of a collagen solution capable of adsorbing coagulation factors VIII and XIII which comprises treating collagen-containing human or animal tissue with pepsin to form a pepsin-treated collagen and dialyzing said pepsin-treated collagen at a temperature in the range of 4° to 25° C. with a phosphate-buffered isotonic solution containing a basic amino acid at a concentration of 5 to 20 mmols/l.
Claim 2
Dependent Claim
66 words
A process for the preparation of a collagen solution capable of adsorbing coagulation factors VIII and XIII which comprises treating collagen-containing human or animal tissue with pepsin to form a pepsin-treated collagen and dialyzing said pepsin-treated collagen at a temperature in the range of 4° to 25° C. with a phosphate-buffered isotonic solution containing a basic amino acid at a concentration of 5 to 20 mmols/l.
Claim 3
Dependent Claim
15 words
The process of claim 1 wherein said pepsin-treated collagen is dialyzed for about 24 hours.
Claim 4
Dependent Claim
15 words
The process of claim 1 wherein said collagen-containing tissue comprises human umbilical cords or placentae.
Claim 5
Dependent Claim
12 words
The process of claim 1 wherein the basic amino acid is arginine.
Claim 6
Dependent Claim
85 words
The process of claim 1 wherein said pepsin-treated collagen is prepared by treating the collagen-containing human or animal tissue with a suitable buffer solution having a pH in the range of 7 to 9 and an aqueous solution of an acid having a pK in the range of 3 to 5 to form a suspension having a pH of about 2 and treating said suspension with pepsin at a temperature of 4° C. to 25° C. for about 24 hours to form the pepsin-treated collagen.
Claim 7
Dependent Claim
25 words
The process of claim 5 wherein said buffer solution is tris-hydrochloric acid with a pH of about 7.4 containing sodium chloride and a complex-forming agent.
Claim 8
Dependent Claim
15 words
The process of claim 5 wherein said suspension is treated with 0.5 grams of pepsin.
References Cited (Backward Citations)
US4066083A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-24 | 1985-11-23 | 1986-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-24 | 1989-11-23 | 1990-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-24 | 1993-11-23 | 1994-05-25 | $7700.00 | Window Closed / Lapsed |