US4331145A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Multiple sclerosis treatment
Assignee: Individual
•
Filing: 1981-01-28
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Granted: 1982-05-25
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Expires: 2001-01-28
Abstract
Abstract A treatment regime is described for multiple sclerosis comprising transcutaneous neuro-stimulation (TNS) and oral administration of d-phenylalanine. The d-phenylalanine prolongs the improvement from the TNS.
Inventors
- 👤 Arthur Winter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 23:26
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7135; A61K31/714; A61K31/185; A61K31/19; A61K31/195
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
59 words
A method of treating patients exhibiting symptoms of multiple sclerosis to reduce spasm and permit more normal functioning which comprises the steps of administering a course of treatment which includes transcutaneous neurostimulation and concomitant and subsequent administration of oral doses of d-phenylalanine for at least a period of time sufficient to extend the therapeutic effects of the transcutaneous neurostimulation.
Claim 2
Independent Claim
59 words
A method of treating patients exhibiting symptoms of multiple sclerosis to reduce spasm and permit more normal functioning which comprises the steps of administering a course of treatment which includes transcutaneous neurostimulation and concomitant and subsequent administration of oral doses of d-phenylalanine for at least a period of time sufficient to extend the therapeutic effects of the transcutaneous neurostimulation.
Claim 3
Dependent Claim
25 words
The method according to claim 1 wherein the d-phenylalanine doses for an adult are 250 mgm. administered three times daily for at least one week.
Claim 4
Dependent Claim
58 words
The method according to claim 1 wherein the transcutaneous neurostimulation consists of substantially square wave pulses, at up to 100 cps, administered at the rate of from five to ten pulses per second, at five to fifteen milliamps, for from five to thirty minutes, via skin electrodes positioned between the spinal chord and the source of the pathology.
Claim 5
Dependent Claim
15 words
The method according to claim 1 wherein additionally, a daily dosage of cyanocobalamin is administered.
Claim 6
Dependent Claim
20 words
The method according to claim 4 wherein the adult dosage of the cynacobalamin is 1,000 micrograms daily by subcutaneous route.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-24 | 1985-11-23 | 1986-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-24 | 1989-11-23 | 1990-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-24 | 1993-11-23 | 1994-05-25 | $7700.00 | Window Closed / Lapsed |