US3864481A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti disease producing synthetic material for the prevention suppression and diagnosis of multiple sclerosis and method of treatment therefor
Assignee: ST LUKES HOSPITAL
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Filing: 1972-12-14
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Granted: 1975-02-04
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Expires: 1992-12-14
Abstract
Abstract Anti disease producing synthetic material for the prevention, suppression or diagnosis of multiple sclerosis in mammals and method of treatment therefor is disclosed. A therapeutic preparation of the synthetic material is adapted to be administered in therapeutic dosage units to mammals and is selected from formulae:
Inventors
- 👤 George A Hashim
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 09:34
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0821; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4713; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/868
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
55 words
THE METHOD OF TREATING A MAMMAL WHICH IS USEFUL FOR THE PREVENTION, SUPPRESION AND DIAGNOSIS OF MULTIPLE SCLEROSIS WHICH COMPRISES: ADMINISTERING TO SAID MAMMAL FROM ABOUT 0.001 MG TO ABOUT 1,000 MICROGRAMS PER KILOGRAM OF BODY WEIGHT OF A SYNTHETIC MATERIAL HAVING THE GENERAL FORMULA SELECTED FROM THE CLASS CONSISTING OF COMPOUNDS OF THE FORMULA:
Claim 2
Independent Claim
55 words
THE METHOD OF TREATING A MAMMAL WHICH IS USEFUL FOR THE PREVENTION, SUPPRESION AND DIAGNOSIS OF MULTIPLE SCLEROSIS WHICH COMPRISES: ADMINISTERING TO SAID MAMMAL FROM ABOUT 0.001 MG TO ABOUT 1,000 MICROGRAMS PER KILOGRAM OF BODY WEIGHT OF A SYNTHETIC MATERIAL HAVING THE GENERAL FORMULA SELECTED FROM THE CLASS CONSISTING OF COMPOUNDS OF THE FORMULA:
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said mammal is a human.
Claim 4
Dependent Claim
28 words
The method of claim 1 wherein the amount of synthetic material administered is from about 0.5 mg to 5.0 mg per kilogram of body weight per unit dosage.
Claim 5
Independent Claim
104 words
The method of treating a mammal which is useful for the prevention, suppression and diagnosis of multiple sclerosis which comprises: administering to said mammal from about 0.001 mg. to about 1,000 micrograms per kilogram of body weight of a synthetic material having the general formula: R1--R2-R3-a Gln - R4--R1)c where; each R1 is an amino acid residue; R2 is selected from the class consisting of Trp and Tyr; R3 is an amino acid residue; R4 is selected from the class consisting of Lys, Arg and His; a is 0-4; b and c are each 0 or at least 1 and n is at least
Claim 6
Independent Claim
104 words
The method of treating a mammal which is useful for the prevention, suppression and diagnosis of multiple sclerosis which comprises: administering to said mammal from about 0.001 mg. to about 1,000 micrograms per kilogram of body weight of a synthetic material having the general formula: R1--R2-R3-a Gln - R4--R1)c where; each R1 is an amino acid residue; R2 is selected from the class consisting of Trp and Tyr; R3 is an amino acid residue; R4 is selected from the class consisting of Lys, Arg and His; a is 0-4; b and c are each 0 or at least 1 and n is at least
Claim 7
Independent Claim
80 words
A method of treating a mammal which is useful for the prevention, suppression and diagnosis of multiple sclerosis which comprises: administering to said mammal from about 0.001 mg. to about 1000 micrograms per kilogram of body weight: (R5--Gln - R4--R1)d where; R1 is an amino acid residue R5 is an amino acid residue; R4 is selected from the class consisting of Lys, Arg and his; c and d are 0 or at least 1; and n is at least 1.
Claim 8
Independent Claim
80 words
A method of treating a mammal which is useful for the prevention, suppression and diagnosis of multiple sclerosis which comprises: administering to said mammal from about 0.001 mg. to about 1000 micrograms per kilogram of body weight: (R5--Gln - R4--R1)d where; R1 is an amino acid residue R5 is an amino acid residue; R4 is selected from the class consisting of Lys, Arg and his; c and d are 0 or at least 1; and n is at least 1.
Claim 9
Dependent Claim
27 words
A method according to claim 1 wherein said administering is by sub-cutaneous injection, whereby a diagnosis of multiple sclerosis is indicated by a delayed type skin hypersensitivity.
Claim 10
Dependent Claim
16 words
A method according to claim 1 wherein said administering is by sub-cutaneous, intramuscular or intravenous injection.
Claim 11
Dependent Claim
34 words
A method according to claim 4 wherein said synthetic material is of the formula: H - Gly - Gly - Trp - Gly - Gly - Gly - Gly -Gln - Lys - OH.
Claim 12
Dependent Claim
16 words
A method according to claim 4 wherein said administering is by sub-cutaneous, intra-muscular or intravenous injection.
References Cited (Backward Citations)
US3274060A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-03 | 1978-08-05 | 1979-02-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-03 | 1982-08-05 | 1983-02-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-03 | 1986-08-05 | 1987-02-04 | $7700.00 | Window Closed / Lapsed |