Acyl-carnitine and use thereof in parenteral administration of triglycerides

Claim 2

In the method of increasing in a human the level of fatty acids selected from the group consisting of oleic acid, linoleic acid, palmitic acid, stearic acid and linolenic acid by parenteral intravenous administration of one or more triglycerides of said fatty acid to a human, the improvement which comprises sumultaneously administering a quantity of an acyl-carnitine sufficient to enhance the oxidation of said fatty acids in the body of said human, said acyl-carnitine having the general formula ##STR3## wherein R represents acetyl, propionyl, butyryl, hydroxy butyryl, hexanoyl, octanoyl, decanoyl, palmitoyl, stearoyl, acetoacetyl, succinyl, isovaleryl and crotonyl.

Claim 5

The method according to claim 1, wherein said acyl-carnitine is an L-acyl-carnitine.

Claim 6

The method according to claim 1, which further comprises orally or parenterally administering daily for 12 to 24 hours after discontinuation of said triglyceride administration, from about 30 mg to about 200 mg of said acyl-carnitine per kg of body weight.

Claim 7

A parenterally administerable aqueous intravenous pharmaceutical composition for increasing in the body of a human recipient thereof the level of fatty acids selected from the group consisting of oleic acid, linoleic acid, palmitic acid, stearic acid and linolenic acid, said composition comprising a quantity of one or more triglycerides of said fatty acids sufficient upon hydrolysis in the body to afford a nutritionally effective amount of said fatty acid, and an amount of an acyl-carnitine or a pharmaceutically acceptable salt thereof sufficient to enhance the oxidation of said fatty acids in the body, said acyl-carnitine having the general formula ##STR5## wherein R represents acetyl, propionyl, butyryl, hydroxy butyryl, hexanoyl, octanoyl, decanoyl, palmitoyl, stearoyl, acetoacetyl, succinyl, isovaleryl and crotony.

Claim 8

A parenterally administerable aqueous intravenous pharmaceutical composition for increasing in the body of a human recipient thereof the level of fatty acids selected from the group consisting of oleic acid, linoleic acid, palmitic acid, stearic acid and linolenic acid, said composition comprising a quantity of one or more triglycerides of said fatty acids sufficient upon hydrolysis in the body to afford a nutritionally effective amount of said fatty acid, and an amount of an acyl-carnitine or a pharmaceutically acceptable salt thereof sufficient to enhance the oxidation of said fatty acids in the body, said acyl-carnitine having the general formula ##STR5## wherein R represents acetyl, propionyl, butyryl, hydroxy butyryl, hexanoyl, octanoyl, decanoyl, palmitoyl, stearoyl, acetoacetyl, succinyl, isovaleryl and crotony.

Claim 9

The composition according to claim 5, wherein said amount of acyl-carnitine or pharmaceutically acceptable salt thereof is from about 2 to about 30 g/l.

Claim 10

The composition according to claim 5 comprising: ______________________________________ soybean oil 50-200 g/l glycerine 22-26 g/l egg yolk phospolipids (ovolecithin) 10.5-12.5 g/l acetyl-carnitine or a pharmaceutically acceptable salt thereof 5-25 g/l sodium hydroxide sufficient to adjust pH of composition to 5.5-9.0 distilled water balance to 1 liter. ______________________________________

Claim 11

The composition according to claim 5, comprising: ______________________________________ cottonseed oil 100-200 g/l soybean lecithin 10-30 g/l sorbitol 40-60 g/l D,L-α-tocopherol 0.5-1 g/l acetyl-carnitine or pharmaceutically acceptable salt thereof 5-25 g/l distilled water balance to 1 liter. ______________________________________

Claim 12

The composition according to claim 5, comprising ______________________________________ sesame oil 100-200 g/l glycerine 20-30 g/l cetylstearylsulfonic acid 1-1.5 g/l propionyl-carnitine or pharmaceutically acceptable salt thereof 3-20 g/l distilled water balance to 1 liter ______________________________________

Claim 13

The composition according to claim 5, comprising: ______________________________________ safflower oil 100-200 g/l sorbitol 50-70 g/l polysorbate 8-12 g/l D,L-α-tocopherol 0.5-1 g/l acetoacetyl-carnitine or pharmaceutically acceptable salt thereof 2-20 g/l distilled water balance to 1 liter ______________________________________

Claim 14

The composition according to claim 5, wherein said acyl-carnitine is L-acyl-carnitine.

Claim 15

The composition according to claim 7, wherein said acetyl-carnitine is L-acetyl-carnitine.

Claim 16

The composition according to claim 8, wherein said acetyl-carnitine is L-acetyl-carnitine.

Claim 17

The composition according to claim 2, wherein said propionyl-carnitine is L-propionyl-carnitine.