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US4323649A
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Biotransformations using methane-utilizing bacteria
Assignee: Imperial Chemical Industries Ltd
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Filing: 1980-02-28
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Granted: 1982-04-06
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Expires: 2000-02-28
Abstract
Abstract A process for the partial degradation of complex cyclicorganic compounds such as 1-phenylheptane and m-chlorotoluene using methane-utilizing microorganisms or enzyme extracts thereof containing the enzymes methane mono-oxygenase and/or a de-halogenase. The preferred microorganism is Methylosinus trichosporium strain OB3b (NCIB 11131).
Inventors
- 👤 Irving J. Higgins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 08:15
CPC Classifications
C; C02; C02F; C02F3/00; C02F3/34; C02F3/342; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P7/00; C12P7/02; C12P7/22; C12P7/40; C12R; C12R2001/00; C12R2001/01; C12R2001/26; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/858
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
105 words
A process for the partial degradation of a complex organic compound selected from the group consisting of mono-alkyl benzenes having from 5 to 12 carbon atoms in the alkyl group and di-substituted lower alkyl benzenes having at least one halogen substituent, into at least one other oxidized and/or dehalogenated organic compound, said process comprising the step of contacting the complex organic compound with a methane-utilizing bacterium of a genus selected from the group consisting of Methylosinus, Methylocystis, Methylomonas, Methylococcus and Methylobacterium or with an extract thereof containing a methane mono-oxygenase and/or a de-halogenase enzyme under conditions suitable for enzymatically partially degrading the complex organic compound.
Claim 2
Dependent Claim
105 words
A process for the partial degradation of a complex organic compound selected from the group consisting of mono-alkyl benzenes having from 5 to 12 carbon atoms in the alkyl group and di-substituted lower alkyl benzenes having at least one halogen substituent, into at least one other oxidized and/or dehalogenated organic compound, said process comprising the step of contacting the complex organic compound with a methane-utilizing bacterium of a genus selected from the group consisting of Methylosinus, Methylocystis, Methylomonas, Methylococcus and Methylobacterium or with an extract thereof containing a methane mono-oxygenase and/or a de-halogenase enzyme under conditions suitable for enzymatically partially degrading the complex organic compound.
Claim 3
Dependent Claim
27 words
A process according to claim 1 wherein the complex organic compound is 1-phenylheptane which is degraded to produce a mixture comprising benzoic acid, cinnamic acid and p-hydroxy-1-phenylheptane.
Claim 4
Dependent Claim
27 words
A process according to claim 1 wherein the complex organic compound is m-chlorotoluene which is degraded to produce a mixture containing benzyl alcohol and a hydroxy-benzyl alcohol.
Claim 5
Dependent Claim
17 words
A process according to claim 1 wherein the methane-utilizing bacterium is Methylosinus trichosporium strain NCIB No. 11131.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-04-05 | 1985-10-05 | 1986-04-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-04-05 | 1989-10-05 | 1990-04-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-04-05 | 1993-10-05 | 1994-04-06 | $7700.00 | Window Closed / Lapsed |