Patent US4323056A successfully refreshed from Google Patents.
US4323056A
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US
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Radio frequency induced hyperthermia for tumor therapy
Assignee: CERATHERM Corp A CORP OF MASSACHUSETTS
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Filing: 1980-05-19
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Granted: 1982-04-06
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Expires: 2000-05-19
Abstract
Abstract The instant invention is directed to a noninvasive tumor treatment modality which results in a reduction of tumor mass and may lead to complete eradication of a tumor. The inventive method comprises localized magnetically-coupled, RF-induced hyperthermia mediated by a material which is non-toxic to and, preferably, compatible with animal tissue and has incorporated therewithin iron-containing crystals of such size, amount, composition, and magnetic properties to impart a coercive force of at least 200 oersteds to the material, and wherein the RF magnetic field has a frequency not in excess of about 10 kilohertz.
Inventors
- 👤 Nicholas F. Borrelli
- 👤 Albert A. Luderer
- 👤 Joseph N. Panzarino
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:09
CPC Classifications
H; H05; H05B; H05B6/00; H05B6/02; H05B6/10; H05B6/105; H05B6/106; A; A61; A61K; A61K41/00; A61K41/0052; A61K9/00; A61K9/48; A61K9/50; A61K9/5094; A61N; A61N1/00; A61N1/40; A61N1/403; A61N1/406; H01; H01F; H01F1/00; H01F1/01; H01F1/03; H01F1/12; H01F1/34; H01F1/36; H01F1/37
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
76 words
A method for reducing the mass of a tumor comprising localized magnetically-coupled, RF-induced hyperthermia mediated by a material which is non-toxic to animal tissue and which has incorporated therewithin magnetic iron-containing crystals of such size, composition, concentration, and magnetic properties to impart a coercive force of at least 200 oersteds to said material, and wherein the frequency of said RF magnetic field will not exceed about 10 kilohertz, allowing essentially only magnetic hysteresis heating to occur.
Claim 2
Independent Claim
76 words
A method for reducing the mass of a tumor comprising localized magnetically-coupled, RF-induced hyperthermia mediated by a material which is non-toxic to animal tissue and which has incorporated therewithin magnetic iron-containing crystals of such size, composition, concentration, and magnetic properties to impart a coercive force of at least 200 oersteds to said material, and wherein the frequency of said RF magnetic field will not exceed about 10 kilohertz, allowing essentially only magnetic hysteresis heating to occur.
Claim 3
Dependent Claim
24 words
A method according to claim 1 wherein said mediating material is a ceramic selected from the group consisting of glass, glass-ceramic, and sintered ceramic.
Claim 4
Dependent Claim
25 words
A method according to claim 2 wherein said ceramic is a glass having a base composition selected from the group of phosphates, silicates, and borates.
Claim 5
Dependent Claim
29 words
A method according to claim 2 wherein said ceramic is injected as a dispersion of fine powder into the tumor and/or into normal tissue immediately adjacent to the tumor.
Claim 6
Dependent Claim
34 words
A method according to claim 2 wherein said ceramic is injected as a dispersion of fine powder into a vein or artery at a site near or distal to the site of the tumor.
Claim 7
Dependent Claim
26 words
A method according to claim 5 wherein the passage of said ceramic material through a vein or artery is guided through the use of a magnet.
Claim 8
Dependent Claim
28 words
A method according to claim 2 wherein said ceramic material is derivatized with tumor specific ions or with antibodies and/or other similarly bioactive molecules directed against the tumor.
Claim 9
Dependent Claim
22 words
A method according to claim 2 wherein said ceramic material is designed to precipitate at the pH value demonstrated by the tumor.
Claim 10
Dependent Claim
20 words
A method according to claim 2 wherein said ceramic material is presensitized to have an affinity for the tumor species.
Claim 11
Dependent Claim
17 words
A method according to claim 1 wherein said iron-containing crystals consist essentially of magnetite or a ferrite.
Claim 12
Dependent Claim
22 words
A method according to claim 10 wherein said ferrite is selected from the group of lithium, cobalt, nickel, manganese, and barium ferrite.
Claim 13
Dependent Claim
17 words
A method according to claim 1 wherein said RF treatment is undertaken via a series of exposures.
References Cited (Backward Citations)
US2161292A
Cited
US3474777A
Cited
US4106488A
Cited
SU522688A1
Cited
US4136683A
Cited
GB2024007A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-04-05 | 1985-10-05 | 1986-04-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-04-05 | 1989-10-05 | 1990-04-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-04-05 | 1993-10-05 | 1994-04-06 | $7700.00 | Window Closed / Lapsed |