US4322362A
Expired / Lapsed
US
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Salts of 2-hydroxymalonate platinum complexes
Assignee: Bristol Myers Co
•
Filing: 1981-01-22
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Granted: 1982-03-30
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Expires: 2001-01-22
Abstract
Abstract Disclosed are water-soluble salts of the known coordination compounds 2-hydroxymalonato diammine platinum (II), 2-hydroxymalonato (1,2-diaminocyclohexane)platinum (II) and 2-hydroxymalonato (1,1-diaminomethylcyclohexane)platinum (II). The novel sodium and ammonium salts of the present invention possess high water-solubility, thus allowing intravenous dosage forms to be prepared.
Inventors
- 👤 Murray A. Kaplan
- 👤 Alphonse P. Granatek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 09:28
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
8 words
The ammonium salt of 2-hydroxymalonato diammine platinum (II).
Claim 2
Dependent Claim
8 words
The ammonium salt of 2-hydroxymalonato diammine platinum (II).
Claim 3
Dependent Claim
8 words
The sodium salt of 2-hydroxymalonato diammine platinum (II).
Claim 4
Dependent Claim
8 words
The sodium salt of 2-hydroxymalonato diammine platinum (II).
Claim 5
Dependent Claim
6 words
The ammonium salt of 2-hydroxymalonato(1,2-diaminocyclohexane)platinum (II).
Claim 6
Dependent Claim
6 words
The ammonium salt of 2-hydroxymalonato(1,2-diaminocyclohexane)platinum (II).
Claim 7
Dependent Claim
6 words
The sodium salt of 2-hydroxymalonato(1,2-diaminocyclohexane)platinum (II).
Claim 8
Dependent Claim
6 words
The sodium salt of 2-hydroxymalonato(1,2-diaminocyclohexane)platinum (II).
Claim 9
Dependent Claim
7 words
The ammonium salt of 2-hydroxymalonato (1,1-diaminomethylcyclohexane)platinum (II).
Claim 10
Dependent Claim
7 words
The ammonium salt of 2-hydroxymalonato (1,1-diaminomethylcyclohexane)platinum (II).
Claim 11
Dependent Claim
7 words
The sodium salt of 2-hydroxymalonato (1,1-diaminomethylcyclohexane)platinum (II).
Claim 12
Dependent Claim
7 words
The sodium salt of 2-hydroxymalonato (1,1-diaminomethylcyclohexane)platinum (II).
Claim 13
Dependent Claim
57 words
A process for preparing the ammonium salt of 2-hydroxymalonato diammine platinum (II) which comprises the steps of (1) providing a suspension of 2-hydroxymalonato diammine platinum (II) in water; (2) adding to said suspension with stirring at least about one equivalent of ammonium hydroxide to form a solution; and (3) recovering the desired ammonium salt from said solution.
Claim 14
Dependent Claim
57 words
A process for preparing the ammonium salt of 2-hydroxymalonato diammine platinum (II) which comprises the steps of (1) providing a suspension of 2-hydroxymalonato diammine platinum (II) in water; (2) adding to said suspension with stirring at least about one equivalent of ammonium hydroxide to form a solution; and (3) recovering the desired ammonium salt from said solution.
Claim 15
Dependent Claim
13 words
The process according to claim 7 wherein the salt is recovered by lyophilization.
Claim 16
Dependent Claim
18 words
The process according to claim 7 wherein the salt is recovered by solvent precipitation with acetone or isopropanol.
Claim 17
Dependent Claim
23 words
The process according to claim 7, 8 or 9 wherein the solution prepared in step (2) is filtered prior to the recovery step.
Claim 18
Dependent Claim
55 words
A process for preparing the sodium salt of 2-hydroxymalonato diammine platinum (II) which comprises the steps of (1) providing a suspension of 2-hydroxymalonato diammine platinum (II) in water; (2) adding to said suspension with stirring about one equivalent of sodium hydroxide to form a solution; and (3) recovering the desired sodium salt from said solution.
Claim 19
Dependent Claim
55 words
A process for preparing the sodium salt of 2-hydroxymalonato diammine platinum (II) which comprises the steps of (1) providing a suspension of 2-hydroxymalonato diammine platinum (II) in water; (2) adding to said suspension with stirring about one equivalent of sodium hydroxide to form a solution; and (3) recovering the desired sodium salt from said solution.
Claim 20
Dependent Claim
13 words
The process according to claim 11 wherein the salt is recovered by lyophilization.
Claim 21
Dependent Claim
18 words
The process according to claim 11 wherein the salt is recovered by solvent precipitation with acetone or isopropanol.
Claim 22
Dependent Claim
23 words
The process according to claim 11, 12 or 13 wherein the solution prepared in step (2) is filtered prior to the recovery step.
Claim 23
Dependent Claim
53 words
A process for preparing the ammonium salt of 2-hydroxymalonato(1,2-diaminocyclohexane)platinum (II) which comprises the steps of (1) providing a suspension of 2-hydroxymalonato(1,2-diaminocyclohexane)platinum (II) in water; (2) adding to said suspension with stirring at least about one equivalent of ammonium hydroxide to form a solution; and (3) recovering the desired ammonium salt from said solution.
Claim 24
Dependent Claim
53 words
A process for preparing the ammonium salt of 2-hydroxymalonato(1,2-diaminocyclohexane)platinum (II) which comprises the steps of (1) providing a suspension of 2-hydroxymalonato(1,2-diaminocyclohexane)platinum (II) in water; (2) adding to said suspension with stirring at least about one equivalent of ammonium hydroxide to form a solution; and (3) recovering the desired ammonium salt from said solution.
Claim 25
Dependent Claim
13 words
The process according to claim 15 wherein the salt is recovered by lyophilization.
Claim 26
Dependent Claim
18 words
The process according to claim 15 wherein the salt is recovered by solvent precipitation with acetone or isopropanol.
Claim 27
Dependent Claim
23 words
The process according to claim 15, 16 or 17 wherein the solution prepared in step (2) is filtered prior to the recovery step.
Claim 28
Dependent Claim
51 words
A process for preparing the sodium salt of 2-hydroxymalonato(1,2-diaminocyclohexane)platinum (II) which comprises the steps of (1) providing a suspension of 2-hydroxymalonato(1,2-diaminocyclohexane)platinum (II) in water; (2) adding to said suspension with stirring about one equivalent of sodium hydroxide to form a solution; and (3) recovering the desired sodium salt from said solution.
Claim 29
Dependent Claim
51 words
A process for preparing the sodium salt of 2-hydroxymalonato(1,2-diaminocyclohexane)platinum (II) which comprises the steps of (1) providing a suspension of 2-hydroxymalonato(1,2-diaminocyclohexane)platinum (II) in water; (2) adding to said suspension with stirring about one equivalent of sodium hydroxide to form a solution; and (3) recovering the desired sodium salt from said solution.
Claim 30
Dependent Claim
13 words
The process according to claim 19 wherein the salt is recovered by lyophilization.
Claim 31
Dependent Claim
18 words
The process according to claim 19 wherein the salt is recovered by solvent precipitation with acetone or isopropanol.
Claim 32
Dependent Claim
23 words
The process according to claim 19, 20 or 21 wherein the solution prepared in step (2) is filtered prior to the recovery step.
Claim 33
Dependent Claim
54 words
A process for preparing the ammonium salt of 2-hydroxymalonato (1,1-diaminomethylcyclohexane)platinum (II) which comprises the steps of (1) providing a suspension of 2-hydroxymalonato(1,1-diaminomethylcyclohexane)platinum (II) in water; (2) adding to said suspension with stirring at least about one equivalent of ammonium hydroxide to form a solution; and (3) recovering the desired ammonium salt from said solution.
Claim 34
Dependent Claim
54 words
A process for preparing the ammonium salt of 2-hydroxymalonato (1,1-diaminomethylcyclohexane)platinum (II) which comprises the steps of (1) providing a suspension of 2-hydroxymalonato(1,1-diaminomethylcyclohexane)platinum (II) in water; (2) adding to said suspension with stirring at least about one equivalent of ammonium hydroxide to form a solution; and (3) recovering the desired ammonium salt from said solution.
Claim 35
Dependent Claim
13 words
The process according to claim 23 wherein the salt is removed by lyophilization.
Claim 36
Dependent Claim
18 words
The process according to claim 23 wherein the salt is recovered by solvent precipitation with acetone or isopropanol.
Claim 37
Dependent Claim
22 words
The process according to claim 23, 24 or 25 wherein the solution in step (2) is filtered prior to the recovery step.
Claim 38
Dependent Claim
53 words
A process for preparing the sodium salt of 2-hydroxymalonato (1,1-diaminomethylcyclohexane)platinum (II) which comprises the steps of (1) providing a suspension of 2-hydroxymalonato (1,1-diaminomethylcyclohexane)platinum (II) in water; (2) adding to said suspension with stirring about one equivalent of sodium hydroxide to form a solution; and (3) recovering the desired sodium salt from said solution.
Claim 39
Dependent Claim
53 words
A process for preparing the sodium salt of 2-hydroxymalonato (1,1-diaminomethylcyclohexane)platinum (II) which comprises the steps of (1) providing a suspension of 2-hydroxymalonato (1,1-diaminomethylcyclohexane)platinum (II) in water; (2) adding to said suspension with stirring about one equivalent of sodium hydroxide to form a solution; and (3) recovering the desired sodium salt from said solution.
Claim 40
Dependent Claim
13 words
The process according to claim 27 wherein the salt is recovered by lyophilization.
Claim 41
Dependent Claim
18 words
The process according to claim 27 wherein the salt is recovered by solvent precipitation with acetone or isopropanol.
Claim 42
Dependent Claim
23 words
The process according to claim 27, 28 or 29 wherein the solution prepared in step (2) is filtered prior to the recovery step.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-03-29 | 1985-09-28 | 1986-03-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-03-29 | 1989-09-28 | 1990-03-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-03-29 | 1993-09-28 | 1994-03-30 | $7700.00 | Window Closed / Lapsed |