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US4317877A
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US
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Process for detecting the presence of malignant and pre-malignant cells in humans
Assignee: Memorial Sloan Kettering Cancer Center
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Filing: 1980-06-05
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Granted: 1982-03-02
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Expires: 2000-06-05
Abstract
Abstract Malignant and pre-malignant cells in humans are detected by contacting an antibody to oncofoetal deoxythymidine kinase with human cells and detecting the presence of cells containing oncofoetal deoxythymidine kinase antigen bound to the antibody.
Inventors
- 👤 M. Earl Balis
- 👤 Paul J. Higgins
- 👤 Josephine S. Salser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 10:03
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/575; G01N33/5757; G01N33/573
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
45 words
Process for detecting the presence of malignant and pre-malignant cells in humans which comprises: (i) incubating an antibody to placental or tumor deoxythymidine kinase with human cells; and (ii) detecting the presence of cells containing placental or tumor deoxythymidine kinase antigen bound to said antibody.
Claim 2
Dependent Claim
45 words
Process for detecting the presence of malignant and pre-malignant cells in humans which comprises: (i) incubating an antibody to placental or tumor deoxythymidine kinase with human cells; and (ii) detecting the presence of cells containing placental or tumor deoxythymidine kinase antigen bound to said antibody.
Claim 3
Dependent Claim
12 words
Process of claim 1 wherein the antibody is incubated in an antiserum.
Claim 4
Dependent Claim
15 words
Process of claim 1 wherein the antibody is incubated with human cells grown in culture.
Claim 5
Dependent Claim
14 words
Process of claim 1 wherein the antibody is incubated with a human cell smear.
Claim 6
Dependent Claim
14 words
Process of claim 1 wherein the antibody is incubated with a human tissue section.
Claim 7
Dependent Claim
20 words
Process of claim 1 wherein the antibody bound cells are detected by indirect immunofluorescense or by coupled immuno peroxidase assay.
Claim 8
Dependent Claim
13 words
Process of claim 1 wherein the antibody is made against placental deoxythymidine kinase.
Claim 9
Dependent Claim
13 words
Process of claim 1 wherein the antibody is made against tumor deoxythymidine kinase.
References Cited (Backward Citations)
US3663684A
Cited
US3974269A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-03-01 | 1985-08-31 | 1986-03-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-03-01 | 1989-08-31 | 1990-03-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-03-01 | 1993-08-31 | 1994-03-02 | $7700.00 | Window Closed / Lapsed |