US4314993A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Immunogenic E. coli ST enterotoxin derivatives and compositions containing them
Assignee: SmithKline RIT
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Filing: 1980-04-04
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Granted: 1982-02-09
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Expires: 2000-04-04
Abstract
Abstract E. coli heat stable (ST) enterotoxin derivatives are prepared by reaction of E. coli ST enterotoxin with crosslinking agents for proteins. The so-obtained crosslinked ST enterotoxins show immunogenic activity; they are valuable prophylactic agent for protecting man and animals against diarrheal disease provoked by E. coli enterotoxin and they may be formulated into compositions for intramuscular, subcutaneous or oral administration.
Inventors
- 👤 Frans V. Wijnendaele
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 18:50
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/02; A61K39/025; A61K39/0258; Y; Y02; Y02A; Y02A50/00; Y02A50/30; Y10; Y10S; Y10S530/00; Y10S530/82; Y10S530/825
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
27 words
A E. coli ST enterotoxin derivative which consists in E. coli enterotoxin crosslinked with a dialdehyde, a di-ketone, a carbodiimide, an isocyanate, an epihalohydrin or a difluoride.
Claim 2
Dependent Claim
27 words
A E. coli ST enterotoxin derivative which consists in E. coli enterotoxin crosslinked with a dialdehyde, a di-ketone, a carbodiimide, an isocyanate, an epihalohydrin or a difluoride.
Claim 3
Dependent Claim
43 words
A composition for immunizing humans or animals against diarrheal disease due to E. coli enterotoxin infection which comprises an E. coli ST enterotoxin derivative of claim 1, a pharmaceutical or veterinary carrier for intramuscular, subcutaneous or oral administration thereof and a stabilizer therefor.
References Cited (Backward Citations)
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Cited
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Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-02-08 | 1985-08-10 | 1986-02-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-02-08 | 1989-08-10 | 1990-02-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-02-08 | 1993-08-10 | 1994-02-09 | $7700.00 | Window Closed / Lapsed |