Patent US4311712A successfully refreshed from Google Patents.
US4311712A
Expired / Lapsed
US
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Process for preparing freeze-dried liposome compositions
Assignee: Syngenta Ltd
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Filing: 1979-08-20
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Granted: 1982-01-19
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Expires: 1999-08-20
Abstract
Abstract Process for preparing a freeze-dried, potential liposome, mixture which comprises either (a) dissolving at least one liposome-forming amphipathic lipid, at least one biologically-active compound, and optionally one or more adjuvants, in a suitable solvent, and then freeze-drying the solution, or (b) preparing by any known method an aqueous liposome composition containing at least one biologically-active compound, and then freeze-drying the said aqueous liposome composition. Process for preparing an aqueous liposome composition which comprises dispersing said freeze-dried, potential liposome, mixture, obtained by procedure (a) or (b), in a suitable aqueous medium.
Inventors
- 👤 John R. Evans
- 👤 Francis J. T. Fildes
- 👤 Jean E. Oliver
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:48
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1277
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
53 words
A method for the manufacture of a freeze-dried, potential liposome, mixture which comprises dissolving at least one liposome-forming amphipathic lipid and at least one lipid-soluble or lipid-bound biologically active compound in an organic solvent which remains solid during the freeze-drying process, and then freeze-drying the solution to produce a freeze-dried, potential liposome, mixture.
Claim 2
Independent Claim
53 words
A method for the manufacture of a freeze-dried, potential liposome, mixture which comprises dissolving at least one liposome-forming amphipathic lipid and at least one lipid-soluble or lipid-bound biologically active compound in an organic solvent which remains solid during the freeze-drying process, and then freeze-drying the solution to produce a freeze-dried, potential liposome, mixture.
Claim 3
Dependent Claim
16 words
The method claimed in claim 1 in which the lipid is a natural or synthetic lecithin.
Claim 4
Dependent Claim
15 words
The method claimed in claim 1 in which the biologically active compound is a medicament.
Claim 5
Dependent Claim
35 words
The method claimed in claim 1 in which there is present at least one adjuvant selected from the group consisting of cholesterol, substances which provide a negative charge, and substances which provide a positive charge.
Claim 6
Dependent Claim
18 words
The method claimed in claim 1 in which the solvent has a melting point close to room temperature.
Claim 7
Dependent Claim
23 words
A new composition of matter which is the freeze-dried, potential liposome, mixture obtained as the product of the method claimed in claim 1.
Claim 8
Dependent Claim
27 words
The method claimed in claim 1 in which the solvent is a member selected from the group consisting of t-butanol, n-butanol, dioxan, acetic acid, pyridine and piperidine.
Claim 9
Independent Claim
76 words
A method for the manufacture of an aqueous liposome preparation containing at least one lipid-soluble or lipid-bound biologically active compound, which comprises dispersing a freeze-dried, potential liposome, mixture in a suitable aqueous medium, the said freeze-dried, potential liposome, mixture being obtained by dissolving at least one liposome-forming amphipathic lipid and at least one lipid-soluble or lipid-bound biologically active compound in an organic solvent which remains solid during the freeze-drying process, and then freeze-drying the resulting solution.
Claim 10
Independent Claim
76 words
A method for the manufacture of an aqueous liposome preparation containing at least one lipid-soluble or lipid-bound biologically active compound, which comprises dispersing a freeze-dried, potential liposome, mixture in a suitable aqueous medium, the said freeze-dried, potential liposome, mixture being obtained by dissolving at least one liposome-forming amphipathic lipid and at least one lipid-soluble or lipid-bound biologically active compound in an organic solvent which remains solid during the freeze-drying process, and then freeze-drying the resulting solution.
Claim 11
Dependent Claim
23 words
An aqueous liposome preparation containing at least one lipid-soluble or lipid-bound biologically active compound, obtained by a method as claimed in claim 8.
Claim 12
Dependent Claim
15 words
The method claimed in claim 8 in which the biologically active compound is a medicament.
Claim 13
Dependent Claim
35 words
The method claimed in claim 8 in which there is present at least one adjuvant selected from the group consisting of cholesterol, substances which provide a negative charge, and substances which provide a positive charge.
Claim 14
Dependent Claim
23 words
An aqueous liposome preparation containing at least one lipid-soluble or lipid-bound biologically active compound, obtained by a method as claimed in claim 11.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-01-18 | 1985-07-20 | 1986-01-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-01-18 | 1989-07-20 | 1990-01-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-01-18 | 1993-07-20 | 1994-01-19 | $7700.00 | Window Closed / Lapsed |