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US4309433A Expired / Lapsed US ⏱️ 0.0 years remaining

Pyridinecarbonamido-oxy or thio loweralkyl-1-(diloweralkylaminoloweralkyl)benzene and derivatives thereof, compositions containing same and method of using same

Assignee: Shionogi and Co Ltd
•
Filing: 1980-06-30
•
Granted: 1982-01-05
•
Expires: 2000-06-30
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Abstract

Abstract An aminoalkylbenzene derivative of the formula: ##STR1## [wherein A is oxygen or sulfur; Y is oxo, thioxo, or cyanoimino; a is an integer of 1 to 3; b is an integer of 0 to 3; c is an integer of 1 to 4; R 1 is alkyl; R 2 is hydrogen or alkyl; or R 1 and R 2 taken together represent pyrrolidinyl; R is hydrogen, cycloalkyl, trihaloalkyl, alkoxy, dialkylamino, aryl, aroyl, heterocyclic group, or a group of the formula: ##STR2## (wherein R 3 is hydrogen, halogen, amino, alkyl, alkylamino, dialkylamino, alkylthio, or aryloxy; R 4 is hydrogen, alkyl, alkenyl, aryl, or heterocyclic group; or R 3 and R 4 taken together represent alkylidene or aralkylidene; with the proviso that the above aryl, aroyl, and heterocyclic group can be substituted by 1 to 3 substituents] and its pharmaceutically acceptable acid addition salts being useful as histamine H 2 blockers, especially peptic ulcer remedies, are provided via several routes.

Inventors

  • 👤 Kentaro Hirai
  • 👤 Teruyuki Ishiba
  • 👤 Shigeru Matsutani
  • 👤 Itsuo Makino
  • 👤 Toshio Fujishita
  • 👤 Masami Doteuchi
  • 👤 Koichi Otani

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-10 01:57
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/81; A; A61; A61P; A61P43/00; C07C; C07C323/00; C07C323/23; C07C323/24; C07C323/29; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; C07D207/18; C07D207/22; C07D207/24; C07D207/26; C07D207/273; C07D207/277; C07D207/28; C07D213/82; C07D257/00; C07D257/02; C07D257/04; C07D261/00; C07D261/02; C07D261/06; C07D261/10; C07D261/18; C07D271/00; C07D271/02; C07D271/06; C07D295/00; C07D295/04; C07D295/08; C07D295/096; C07D295/14; C07D295/145; C07D295/15; C07D333/00; C07D333/02; C07D333/04; C07D333/26; C07D333/38; C07D335/00; C07D335/04; C07D335/06

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 114 words
A compound of the formula: ##STR121## wherein A is oxygen or sulfur, Y is oxo or thioxo, a is an integer of 1 to 3, b is an integer of 0 to 3, c is an integer of 1 to 4, R 1 is C 1 to C 5 alkyl, R 2 is hydrogen or C 1 to C 5 alkyl, or R 1 and R 2 taken together represent pyrrolidinyl, and R is pyridyl or pyridyl substituted by 1 to 3 substituents selected from the group consisting of halogen, nitro, oxo, phenyl, C 1 to C 5 alkyl and C 1 to C 5 alkanoyl or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim 114 words
A compound of the formula: ##STR121## wherein A is oxygen or sulfur, Y is oxo or thioxo, a is an integer of 1 to 3, b is an integer of 0 to 3, c is an integer of 1 to 4, R 1 is C 1 to C 5 alkyl, R 2 is hydrogen or C 1 to C 5 alkyl, or R 1 and R 2 taken together represent pyrrolidinyl, and R is pyridyl or pyridyl substituted by 1 to 3 substituents selected from the group consisting of halogen, nitro, oxo, phenyl, C 1 to C 5 alkyl and C 1 to C 5 alkanoyl or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim 8 words
A compound according to claim 1, namely 3-[(2-nicotinamidoethyl)thiomethyl]-1-(dimethylaminomethyl)benzene.
Claim 4
Dependent Claim 8 words
A compound according to claim 1, namely 3-(3-isonicotinamidopropoxy)-1-(1-pyrrolidinylmethyl)benzene.
Claim 5
Dependent Claim 8 words
A compound according to claim 1, namely 3-(3-nicotinamidopropoxy)-1-(1-pyrrolidinylmethyl)benzene.
Claim 6
Dependent Claim 8 words
A compound according to claim 1, namely 3-(3-picolinamidopropoxy)-1-(1-pyrrolidinylmethyl)benzene.
Claim 7
Dependent Claim 34 words
A pharmaceutical composition for use in the treatment of patients suffering from peptic ulcer which comprises a pharmaceutically effective amount of the compound of claim 1 and an inert pharmaceutical carrier or diluent thereof.
Claim 8
Dependent Claim 24 words
A method for the treatment of peptic ulcer which comprises administering a pharmaceutical composition of claim 6 to a patient suffering from peptic ulcer.

References Cited (Backward Citations)

US4255582A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1985-01-04 1985-07-06 1986-01-05 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1989-01-04 1989-07-06 1990-01-05 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1993-01-04 1993-07-06 1994-01-05 $7700.00 Window Closed / Lapsed

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