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US4309213A Expired / Lapsed US ⏱️ 0.0 years remaining

Process of encapsulation by interfacial polycondensation

Assignee: Bayer CropScience SA
•
Filing: 1978-12-26
•
Granted: 1982-01-05
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Expires: 1998-12-26
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Abstract

Abstract The process for the encapsulation of a liquid hydrophobic substance involves, in a first stage, dispersing an organic phase containing the liquid hydrophobic substance to be encapsulated and at least one polyfunctional hydrophobic monomer having functional groups containing the carbonyl or sulphonyl group, in an aqueous phase containing a polyfunctional amine in which the amine functions have been rendered inactive by salification, and subsequently starting polycondensation by liberating the amine functions through the addition, to the aqueous phase, of an equivalent amount of a base which is stronger than the amine. The process has application to the preparation of compounds which can be used especially in the field of plant health.

Inventors

  • 👤 Gerard Graber
  • 👤 Bernard Chatenet
  • 👤 Philippe Pellenard

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-01 21:57
CPC Classifications
B; B01; B01J; B01J13/00; B01J13/02; B01J13/06; B01J13/14; B01J13/16; A; A01; A01N; A01N25/00; A01N25/26; A01N25/28

Claims Analysis

Total Claims: 31
Claim 1
Independent Claim 178 words
In a process for the encapsulation of a liquid hydrophobic substance by interfacial polycondensation comprising in a first stage, dispersing, in an aqueous phase, an organic phase consisting essentially of the liquid hydrophobic substance to be encapsulated and at least one hydrophobic reagent having two or three functional groups selected from the groups consisting of carboxylic acid chloride, sulfonyl acid chloride, isocyanate and mixtures thereof; and then, in a second stage, causing the polycondensation of the hydrophobic reagent with at least one di- or tri-functional amine as a hydrophilic reagent, said liquid hydrophobic substance being inert to said hydrophobic reagent and the polycondensation product thereof: the improvement wherein, prior to said hydrophobic reagent being brought into contact with said di- or tri-functional amine, said di- or tri-functional amine in the aqueous phase has its amine functions rendered unreactive by salification with hydrohalic acid and, in the second stage, the polycondensation is started by liberating the amine functions through the addition, to the aqueous phase, of an equivalent amount of an inorganic base which is stronger than the amine.
Claim 2
Dependent Claim 178 words
In a process for the encapsulation of a liquid hydrophobic substance by interfacial polycondensation comprising in a first stage, dispersing, in an aqueous phase, an organic phase consisting essentially of the liquid hydrophobic substance to be encapsulated and at least one hydrophobic reagent having two or three functional groups selected from the groups consisting of carboxylic acid chloride, sulfonyl acid chloride, isocyanate and mixtures thereof; and then, in a second stage, causing the polycondensation of the hydrophobic reagent with at least one di- or tri-functional amine as a hydrophilic reagent, said liquid hydrophobic substance being inert to said hydrophobic reagent and the polycondensation product thereof: the improvement wherein, prior to said hydrophobic reagent being brought into contact with said di- or tri-functional amine, said di- or tri-functional amine in the aqueous phase has its amine functions rendered unreactive by salification with hydrohalic acid and, in the second stage, the polycondensation is started by liberating the amine functions through the addition, to the aqueous phase, of an equivalent amount of an inorganic base which is stronger than the amine.
Claim 3
Dependent Claim 15 words
Process according to claim 1, wherein said liquid hydrophobic substance is a pure organic compound.
Claim 4
Dependent Claim 17 words
Process according to claim 1, wherein said liquid hydrophobic substance is a solution in an organic solvent.
Claim 5
Dependent Claim 19 words
Process according to claim 1, wherein said liquid hydrophobic substance is a dispersion or suspension in an organic solvent.
Claim 6
Dependent Claim 17 words
Process according to claim 1, wherein said hydrophobic reagent is a di- or tri- functional acid chloride.
Claim 7
Dependent Claim 15 words
Process according to claim 5, wherein said hydrophobic reagent is a chloride of a diacid.
Claim 8
Dependent Claim 23 words
Process according to claim 6, wherein said hydrophobic reagent is a chloride of an aliphatic diacid containing from 2 to 36 carbon atoms.
Claim 9
Dependent Claim 16 words
Process according to claim 7, wherein said hydrophobic reagent is a chloride of a linear diacid.
Claim 10
Dependent Claim 12 words
Process according to claim 8, wherein said hydrophobic reagent is sebacoyl chloride.
Claim 11
Dependent Claim 16 words
Process according to claim 6, wherein said hydrophobic reagent is a chloride of an aromatic diacid.
Claim 12
Dependent Claim 16 words
Process according to claim 1 wherein said hydrophobic reagent is a di- or tri- functional isocyanate.
Claim 13
Dependent Claim 12 words
Process according to claim 11, wherein said hydrophobic reagent is a diisocyanate.
Claim 14
Dependent Claim 12 words
Process according to claim 11, wherein said hydrophobic reagent is a triisocyanate.
Claim 15
Dependent Claim 15 words
Process according to claim 11, wherein two separate polyisocyanates are used as the hydrophobic reagents.
Claim 16
Dependent Claim 30 words
Process according to claim 1, wherein at least one di- or tri-functional acid chloride and at least one di- or tri- functional isocyanate are used simultaneously as the hydrophobic reagents.
Claim 17
Dependent Claim 12 words
Process according to claim 1, wherein said hydrophilic reagent is a diamine.
Claim 18
Dependent Claim 12 words
Process according to claim 1, wherein said hydrophilic reagent is a triamine.
Claim 19
Dependent Claim 16 words
Process according to claim 1, wherein two separate polyfunctional amines are used as the hydrophilic reagents.
Claim 20
Dependent Claim 13 words
Process according to claim 1, wherein said hydrophilic reagent is an aliphatic amine.
Claim 21
Dependent Claim 18 words
Process according to claim 19, wherein said amine functions have been rendered unreactive by salification with hydrochloric acid.
Claim 22
Dependent Claim 17 words
Process according to claim 1, wherein said liquid hydrophobic substance contains an active ingredient for plant health.
Claim 23
Dependent Claim 15 words
Process according to claim 21, wherein that active ingredient for plant health is an insecticide.
Claim 24
Dependent Claim 11 words
Process according to claim 22, wherein that the insecticide is parathion-methyl.
Claim 25
Dependent Claim 10 words
Process according to claim 22, wherein that insecticide is Chlormephos.
Claim 26
Dependent Claim 15 words
Process according to claim 21, wherein that active ingredient for plant health is a herbicide.
Claim 27
Dependent Claim 10 words
Process according to claim 25, wherein said herbicide is Isoproturon.
Claim 28
Dependent Claim 15 words
Process according to claim 1 wherein said hydrophobic reagent comprises 5-50% of said organic phase.
Claim 29
Dependent Claim 31 words
Process according to claim 27 wherein said dispersing of said organic phase in said aqueous phase is effected by stirring sufficiently vigorous to form droplets of 1 micron to 100 microns.
Claim 30
Dependent Claim 20 words
Process according to claim 28 wherein said polycondensation is effected over about 1-5 hours at 0° C. to ambient temperature.
Claim 31
Dependent Claim 28 words
Process according to claim 1 wherein said di- or tri-functional amine is already mixed into said aqueous phase and its amine functions rendered unreactive prior to said dispersing.

References Cited (Backward Citations)

US3575882A Cited
US3577515A Cited
US3607776A Cited
DE2312059A1 Cited
US3901687A Cited
US4107292A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1985-01-04 1985-07-06 1986-01-05 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1989-01-04 1989-07-06 1990-01-05 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1993-01-04 1993-07-06 1994-01-05 $7700.00 Window Closed / Lapsed

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