US4305940A
Expired / Lapsed
US
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Benzamides with local anaesthetic and antiarrhythmic activity, salts, and method of preparation thereof and pharmaceutical compositions therefrom
Assignee: Boehringer Ingelheim Italia SpA
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Filing: 1980-11-18
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Granted: 1981-12-15
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Expires: 2000-11-18
Abstract
Abstract Benzamides of formula I ##STR1## are described, in which R=CH 3 , Cl or COOCH 3 ; R' is a member selected from the group of dialkylamine, pyrrolidine, piperidine, and morpholine radicals. CH 2 R' is in position ortho, meta, or para with respect to the carbonyl group; and their salts thereof with pharmaceutically acceptable acids are described. The novel compounds exhibit local anaesthetic and antiarrhythmic activity.
Inventors
- 👤 Giuseppe Quadro
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 14:44
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/14; C07D295/155; A; A61; A61P; A61P25/00; A61P25/02; A61P9/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
54 words
A benzamide of formula I ##STR16## wherein R=CH 3 , Cl or COOCH 3 ; R' is a member selected from the group of dialkylamine, pyrrolidine, piperidine, and morpholine radicals, CH 2 R' is in position ortho, meta, or para with respect to the carbonyl group; and salts thereof with a pharmaceutically acceptable acid.
Claim 2
Dependent Claim
54 words
A benzamide of formula I ##STR16## wherein R=CH 3 , Cl or COOCH 3 ; R' is a member selected from the group of dialkylamine, pyrrolidine, piperidine, and morpholine radicals, CH 2 R' is in position ortho, meta, or para with respect to the carbonyl group; and salts thereof with a pharmaceutically acceptable acid.
Claim 3
Dependent Claim
19 words
A compound according to claim 1 which is the 2,6-dimethylanilide of 2-diethylaminomethylbenzoic acid and a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
19 words
A compound according to claim 1 which is the 2,6-dimethylanilide of 3-diethylaminomethylbenzoic acid, and a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
19 words
A compound according to claim 1 which is the 2,6-dimethylanilide of 4-diethylaminomethylbenzoic acid and a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
19 words
A compound according to claim 1 which is the 2,6-dimethylanilide of 2-pyrrolidinomethylbenzoic acid and a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
19 words
A compound according to claim 1 which is the 2,6-dimethylanilide of 3-pyrrolidinomethyl-benzoic acid and a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
19 words
A compound according to claim 1 which is the 2,6-dimethylanilide of 4-pyrrolidinomethyl-benzoic acid, and a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
19 words
A compound according to claim 1 which is the 2,6-dimethylanilide of 2-piperidinomethyl-benzoic acid and a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
19 words
A compound according to claim 1 which is the 2,6-dimethylanilide of 3-piperidinomethyl-benzoic acid and a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
19 words
A compound according to claim 1 which is the 2,6-dimethylanilide of 4-piperidinomethyl-benzoic acid, and a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
19 words
A compound according to claim 1 which is the 2,6-dimethylanilide of 2-morpholinomethyl-benzoic acid and a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
20 words
A compound according to claim 1 which is the 2,6-dimethylanilide of 3-morpholinomethyl benzoic acid, and a pharmaceutically acceptable salt thereof.
Claim 14
Dependent Claim
20 words
A compound according to claim 1 which is the 2,6-dimethylanilide of 4-morpholinomethyl benzoic acid, and a pharmaceutically acceptable salt thereof.
Claim 15
Dependent Claim
19 words
A compound according to claim 1 which is the 2-chloro-6-methylanilide of 2-diethylaminomethyl-benzoic acid, and a pharmaceutically acceptable salt thereof.
Claim 16
Dependent Claim
18 words
A compound according to claim 1 which is 2-carbomethoxy-6-methylanilide of 2-diethylaminomethyl-benzoic acid and a pharmaceutically acceptable salt thereof.
Claim 17
Dependent Claim
36 words
A pharmaceutical composition exhibiting local anaesthestic or anti-arrhythmic activity in unit dosage form which contains an effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-14 | 1985-06-15 | 1985-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-14 | 1989-06-15 | 1989-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-14 | 1993-06-15 | 1993-12-15 | $7700.00 | Window Closed / Lapsed |