US4158063A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Acylamino(alkyl)benzene derivatives and process for preparing them
Assignee: Hoechst AG
•
Filing: 1977-01-06
•
Granted: 1979-06-12
•
Expires: 1997-01-06
Abstract
Abstract The invention relates to acylamino(alkyl)benzene derivatives of the general formula ##STR1## in which W represents a group which can be converted into a carboxyl group, or an aldehyde group or an oxymethyl group or their derivatives or also a low molecular weight alkyl group, preferably a methyl group, X represents an aromatic or hetero-aromatic ring system, Y represents a single chemical bond or a hydrocarbon bridge, and Z represents hydrogen or one or even several other substituents, To their preparation and to pharmaceutical compositions containing them. The compounds have blood sugar lowering activity and may be used in the therapy of diabetes mellitus.
Inventors
- 👤 Volker Hitzel
- 👤 Rudi Weyer
- 👤 Elmar Bosies
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 15:06
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/81; C07D213/82; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D307/00; C07D307/77; C07D307/78; C07D307/79; C07D311/00; C07D311/02; C07D311/04; C07D311/58; C07D333/00; C07D333/02; C07D333/04; C07D333/26; C07D333/38
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
87 words
A pharmaceutical composition useful in the treatment of diabetes mellitus consisting essentially of an inert carrier and a hypoglycemically effective amount of a compound of the general formula: ##STR16## wherein R is H, alkyl, alkoxy, alkenoxy, alkoxy-alkoxy, phenoxy, halogen, amino, alkylamino, anilino or CF 3 , R 1 , r 2 and Z' are independently hydrogen, alkyl, alkoxy or halogen, W' is an aldehyde group, a hydroxymethyl group or lower alkyl and Y' is selected from --CH 2 --CH 2 -- and --CH(CH 3 )--CH 2 --.
Claim 2
Dependent Claim
87 words
A pharmaceutical composition useful in the treatment of diabetes mellitus consisting essentially of an inert carrier and a hypoglycemically effective amount of a compound of the general formula: ##STR16## wherein R is H, alkyl, alkoxy, alkenoxy, alkoxy-alkoxy, phenoxy, halogen, amino, alkylamino, anilino or CF 3 , R 1 , r 2 and Z' are independently hydrogen, alkyl, alkoxy or halogen, W' is an aldehyde group, a hydroxymethyl group or lower alkyl and Y' is selected from --CH 2 --CH 2 -- and --CH(CH 3 )--CH 2 --.
Claim 3
Independent Claim
83 words
The method of treating diabetes mellitus in a patient requiring such treatment which comprises administering to said patient a hypoglycemically effective amount of a compound of the general formula: ##STR17## wherein R is H, alkyl, alkoxy, alkenoxy, alkoxy-alkoxy, phenoxy, halogen, amino, alkylamino, anilino or CF 3 , R 1 , r 2 and Z' are independently hydrogen, alkyl, alkoxy or halogen, W' is an aldehyde group, a hydroxymethyl group or lower alkyl and Y' is a hydrocarbon group of 1 to 3 carbons.
Claim 4
Independent Claim
83 words
The method of treating diabetes mellitus in a patient requiring such treatment which comprises administering to said patient a hypoglycemically effective amount of a compound of the general formula: ##STR17## wherein R is H, alkyl, alkoxy, alkenoxy, alkoxy-alkoxy, phenoxy, halogen, amino, alkylamino, anilino or CF 3 , R 1 , r 2 and Z' are independently hydrogen, alkyl, alkoxy or halogen, W' is an aldehyde group, a hydroxymethyl group or lower alkyl and Y' is a hydrocarbon group of 1 to 3 carbons.
Claim 5
Dependent Claim
65 words
An acylamino(alkyl)benzene derivative of the formula: ##STR18## wherein R is H, alkyl, alkoxy, alkenoxy, alkoxy-alkoxy, phenoxy, halogen, amino, alkylamino, anilino or CF 3 , R 1 , r 2 and Z' are independently hydrogen, alkyl, alkoxy or halogen, W' is an aldehyde group, a hydroxymethyl group or lower alkyl and Y' is selected from --CH 2 --CH 2 -- and --CH(CH 3 )--CH 2 --.
Claim 6
Dependent Claim
65 words
An acylamino(alkyl)benzene derivative of the formula: ##STR18## wherein R is H, alkyl, alkoxy, alkenoxy, alkoxy-alkoxy, phenoxy, halogen, amino, alkylamino, anilino or CF 3 , R 1 , r 2 and Z' are independently hydrogen, alkyl, alkoxy or halogen, W' is an aldehyde group, a hydroxymethyl group or lower alkyl and Y' is selected from --CH 2 --CH 2 -- and --CH(CH 3 )--CH 2 --.
Claim 7
Dependent Claim
49 words
An acylamino(alkyl)benzene derivative of the formula: ##STR19## wherein R is alkyl, alkoxy, alkoxy-alkoxy, alkylamino or acylamino, R is hydrogen or halogen, W' is an aldehyde group, a hydroxymethyl group or lower alkyl, Y' is hydrocarbon of 1 to 3 carbons, and Z' is hydrogen, lower alkyl or lower alkoxy.
Claim 8
Dependent Claim
49 words
An acylamino(alkyl)benzene derivative of the formula: ##STR19## wherein R is alkyl, alkoxy, alkoxy-alkoxy, alkylamino or acylamino, R is hydrogen or halogen, W' is an aldehyde group, a hydroxymethyl group or lower alkyl, Y' is hydrocarbon of 1 to 3 carbons, and Z' is hydrogen, lower alkyl or lower alkoxy.
Claim 9
Dependent Claim
1 words
5-Chloro-2-methoxy-N-(2-<4-methylphenyl>-ethyl)-benzamide.
Claim 10
Dependent Claim
1 words
5-Chloro-2-methoxy-N-(2-<4-methylphenyl>-ethyl)-benzamide.
Claim 11
Dependent Claim
1 words
5-Chloro-2-methoxy-N-(2-<4-hydroxymethylphenyl>-ethyl)-benzamide.
Claim 12
Dependent Claim
1 words
5-Chloro-2-methoxy-N-(2-<4-hydroxymethylphenyl>-ethyl)-benzamide.
Claim 13
Dependent Claim
1 words
5-Chloro-2-methoxy-N-(2-<4-formylphenyl>-ethyl)-benzamide.
Claim 14
Dependent Claim
1 words
5-Chloro-2-methoxy-N-(2-<4-formylphenyl>-ethyl)-benzamide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-06-11 | 1982-12-11 | 1983-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-06-11 | 1986-12-11 | 1987-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-06-11 | 1990-12-11 | 1991-06-12 | $7700.00 | Window Closed / Lapsed |