US4305390A
Expired / Lapsed
US
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Method for generating oxygen in an excited electronic state and inactivation of microorganisms
Assignee: Massachusetts Institute of Technology
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Filing: 1979-06-18
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Granted: 1981-12-15
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Expires: 1999-06-18
Abstract
Abstract A system for inactivation of microorganisms and their products (viruses, bacteria, toxins and cells) such as, for example, Herpes simplex viruses by superposition of a component such as, for example, methylene blue (MB) plus light, oxygen and electricity. The system serves to generate the superoxide radical anion (O 2 ) and consequently hydrogen peroxide (H 2 O 2 ) and the hydroxyl radical (OH.), both of which enter into the inactivation process, but each has use beyond said system. The disclosed activating components include methylene blue covalently bonded to conconavalin A to enhance its binding to mammalian lymphoblasts and compounds of d - and f - transition metals such as cis-platinum diamino dichloride.
Inventors
- 👤 Mitchell R. Swartz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 20:10
CPC Classifications
A; A61; A61L; A61L2/00; A61L2/02; A61K; A61K41/00; A61K41/10; A61K41/17; A61L2/16; A61N; A61N1/00; A61N1/40; A61N5/00; A61N5/06; A61N5/0613; A61N5/062; C; C01; C01B; C01B15/00; C01B15/01; C12; C12N; C12N13/00; C12N7/00; G; G01; G01N; G01N33/00; G01N33/0004; G01N33/0009; G01N33/007; A61N2005/0635; A61N2005/0643; A61N2005/0644; A61N2005/065; A61N2005/0651; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16611; C12N2710/16661
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
92 words
A method of generating oxygen in an excited electronic state comprising: (a) providing covalently bonded methylene blue and conconavalin A; (b) adding said covalently bonded methylene blue and conconavalin A to a solution containing oxygen; (c) directing light into the solution; and, (d) simultaneously applying an electric field to the solution, said light and said electric field serving, in combination, to convert said methylene blue to at least one excited electronic state, the thusly activated methylene blue reacting with the oxygen in the solution to produce oxygen in an excited electronic state.
Claim 2
Independent Claim
92 words
A method of generating oxygen in an excited electronic state comprising: (a) providing covalently bonded methylene blue and conconavalin A; (b) adding said covalently bonded methylene blue and conconavalin A to a solution containing oxygen; (c) directing light into the solution; and, (d) simultaneously applying an electric field to the solution, said light and said electric field serving, in combination, to convert said methylene blue to at least one excited electronic state, the thusly activated methylene blue reacting with the oxygen in the solution to produce oxygen in an excited electronic state.
Claim 3
Dependent Claim
50 words
A method in accordance with claim 1 wherein step (b) is conducted by administering said covalently bonded methylene blue and conconavalin A internally to a patient and said oxygen in an excited electronic state is generated in vivo by application of said light and electric field to the patient's body.
Claim 4
Independent Claim
104 words
A method of generating oxygen in an excited electronic state comprising: adding a compound of a d - or f - transition metal to a solution containing oxygen, said compound being capable of assuming at least one excited electronic state when the solution is subjected to light and an electric field; directing light into the solution; and, simultaneously applying an electric field to the solution, said light and said electric field serving in combination to activate said compound to at least one excited electronic state, the thusly activated compound reacting with the oxygen in the solution to produce oxygen in an excited electronic state.
Claim 5
Independent Claim
104 words
A method of generating oxygen in an excited electronic state comprising: adding a compound of a d - or f - transition metal to a solution containing oxygen, said compound being capable of assuming at least one excited electronic state when the solution is subjected to light and an electric field; directing light into the solution; and, simultaneously applying an electric field to the solution, said light and said electric field serving in combination to activate said compound to at least one excited electronic state, the thusly activated compound reacting with the oxygen in the solution to produce oxygen in an excited electronic state.
Claim 6
Dependent Claim
12 words
The method of claim 3 wherein said compound is cis-platinum diamino dichloride.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-14 | 1985-06-15 | 1985-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-14 | 1989-06-15 | 1989-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-14 | 1993-06-15 | 1993-12-15 | $7700.00 | Window Closed / Lapsed |