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US4304777A
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6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics
Assignee: Sanofi SA
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Filing: 1980-04-28
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Granted: 1981-12-08
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Expires: 2000-04-28
Abstract
Abstract 2-R-6-PY-3(2H)-pyridazinones (I) or salts thereof, which are useful as cardiotonics, where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, are prepared by reacting 2-R-4,5-dihydro-6-PY-3(2H)-pyridazinone with a dehydrogenating agent. Also shown are: cardiotonic compositions and a method for increasing cardiac contractility using I or salts; and, the preparation of the corresponding intermediate 4,5-dihydro compounds.
Inventors
- 👤 George Y. Lesher
- 👤 William B. Dickinson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 00:09
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/54; C07D213/57
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
30 words
A 2-R-6-PY-3(2H)-pyridazinone having the formula ##STR3## or pharmaceutically-acceptable acid-addition salt thereof, where PY is 4-pyridinyl or 4-pyridinyl having one or two lower-alkyl substituents, and R is hydrogen, lower-alkyl or lower-hydroxyalkyl.
Claim 2
Dependent Claim
30 words
A 2-R-6-PY-3(2H)-pyridazinone having the formula ##STR3## or pharmaceutically-acceptable acid-addition salt thereof, where PY is 4-pyridinyl or 4-pyridinyl having one or two lower-alkyl substituents, and R is hydrogen, lower-alkyl or lower-hydroxyalkyl.
Claim 3
Dependent Claim
10 words
A compound according to claim 1 where PY is 4-pyridinyl.
Claim 4
Dependent Claim
10 words
A compound according to claim 1 where R is hydrogen.
Claim 5
Dependent Claim
10 words
A compound according to claim 1 where R is methyl.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 where R is ethyl.
Claim 7
Dependent Claim
10 words
A compound according to claim 1 where R is 2-hydroxyethyl.
Claim 8
Dependent Claim
6 words
6-(4-Pyridinyl)-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof.
Claim 9
Dependent Claim
6 words
6-(4-Pyridinyl)-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof.
Claim 10
Dependent Claim
6 words
2-Methyl-6-(4-pyridinyl)-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof.
Claim 11
Dependent Claim
6 words
2-Methyl-6-(4-pyridinyl)-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof.
Claim 12
Dependent Claim
51 words
A cardiotonic composition for increasing cardiac contractility, said composition comprising a pharmaceutically-acceptable inert carrier and, as the active component thereof, an effective amount of a cardiotonic 2-R-6-PY-3-(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4-pyridinyl or 4-pyridinyl having one or two lower-alkyl substituents.
Claim 13
Dependent Claim
51 words
A cardiotonic composition for increasing cardiac contractility, said composition comprising a pharmaceutically-acceptable inert carrier and, as the active component thereof, an effective amount of a cardiotonic 2-R-6-PY-3-(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4-pyridinyl or 4-pyridinyl having one or two lower-alkyl substituents.
Claim 14
Dependent Claim
18 words
The composition according to claim 9 where PY is 4-pyridinyl and R is hydrogen, methyl, ethyl or 2-hydroxyethyl.
Claim 15
Dependent Claim
16 words
The composition according to claim 9 where the cardiotonic is 6-(4-pyridinyl)-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof.
Claim 16
Dependent Claim
16 words
The composition according to claim 9 wherein the cardiotonic is 2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof.
Claim 17
Independent Claim
59 words
The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering orally or parenterally in a solid or liquid dosage form to such patient an effective amount of a cardiotonic 2-R-6-PY-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof, where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4-pyridinyl or 4-pyridinyl having one or two lower-alkyl substituents.
Claim 18
Independent Claim
59 words
The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering orally or parenterally in a solid or liquid dosage form to such patient an effective amount of a cardiotonic 2-R-6-PY-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof, where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4-pyridinyl or 4-pyridinyl having one or two lower-alkyl substituents.
Claim 19
Dependent Claim
18 words
The method according to claim 13 where PY is 4-pyridinyl and R is hydrogen, methyl, ethyl or 2-hydroxyethyl.
Claim 20
Dependent Claim
16 words
The method according to claim 13 where the cardiotonic is 6-(4-pyridinyl)-3(2H)pyridazinone or pharmaceutically-acceptable acid-addition salt thereof.
Claim 21
Dependent Claim
16 words
The method according to claim 13 where the cardiotonic is 2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-07 | 1985-06-08 | 1985-12-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-07 | 1989-06-08 | 1989-12-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-07 | 1993-06-08 | 1993-12-08 | $7700.00 | Window Closed / Lapsed |