Patent US4304692A successfully refreshed from Google Patents.
US4304692A
Expired / Lapsed
US
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Synthesis of biologically active peptides
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1980-07-14
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Granted: 1981-12-08
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Expires: 2000-07-14
Abstract
Abstract A new peptide which has calcitonin-like biological activity which has a shorter amino acid chain and which is chemically more stable than natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having biological activity and processes for producing said resin peptides and said peptides having biological activity.
Inventors
- 👤 John L. Hughes
- 👤 Jay K. Seyler
- 👤 Robert C. Liu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 23:14
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/585; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/28
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
32 words
A resin peptide having the following structure: ##STR24## in which Bz is benzyl, 4-methoxybenzyl, 3,4-dimethylbenzyl, 4 chlorobenzyl, 2,6-dichlorobenzyl, 4-nitrobenzyl or benzhydryl, T is nitro or tosyl, and R is divinylbenzene crosslinked polystyrene.
Claim 2
Dependent Claim
32 words
A resin peptide having the following structure: ##STR24## in which Bz is benzyl, 4-methoxybenzyl, 3,4-dimethylbenzyl, 4 chlorobenzyl, 2,6-dichlorobenzyl, 4-nitrobenzyl or benzhydryl, T is nitro or tosyl, and R is divinylbenzene crosslinked polystyrene.
Claim 3
Dependent Claim
52 words
A resin peptide having the following structure: ##STR25## in which Bz is benzyl, 4-methoxybenzyl, 3,4-dimethylbenzyl, 4 chlorobenzyl, 2,6-dichlorobenzyl, 4-nitrobenzyl or benzyhydryl, T is nitro or tosyl, V is benzyloxycarbonyl, 2-bromobenzyloxycarbonyl or 2-chlorobenzyloxycarbonyl, one of R 1 and R 7 is S-n-alkyl and the other is BZ, and R is divinylbenzene crosslinked polystyrene.
Claim 4
Dependent Claim
52 words
A resin peptide having the following structure: ##STR25## in which Bz is benzyl, 4-methoxybenzyl, 3,4-dimethylbenzyl, 4 chlorobenzyl, 2,6-dichlorobenzyl, 4-nitrobenzyl or benzyhydryl, T is nitro or tosyl, V is benzyloxycarbonyl, 2-bromobenzyloxycarbonyl or 2-chlorobenzyloxycarbonyl, one of R 1 and R 7 is S-n-alkyl and the other is BZ, and R is divinylbenzene crosslinked polystyrene.
Claim 5
Dependent Claim
43 words
A resin peptide having the following structure: ##STR26## in which BZ is benzyl, 4-methoxybenzyl, 3,4-dimehtylbenzyl, 4-chlorobenzyl, 2,6-dichlorobenzyl, 4-nitrobenzyl or benzylhydryl, T is nitro or tosyl, V is benzyloxycarbonyl, 2-bromobenzyloxycarbonyl or 2-chlorobenzyloxycarbonyl, R 7 is Bz or S-n-alkyl, and R is divinylbenzenes crosslinked polystyrene.
Claim 6
Dependent Claim
43 words
A resin peptide having the following structure: ##STR26## in which BZ is benzyl, 4-methoxybenzyl, 3,4-dimehtylbenzyl, 4-chlorobenzyl, 2,6-dichlorobenzyl, 4-nitrobenzyl or benzylhydryl, T is nitro or tosyl, V is benzyloxycarbonyl, 2-bromobenzyloxycarbonyl or 2-chlorobenzyloxycarbonyl, R 7 is Bz or S-n-alkyl, and R is divinylbenzenes crosslinked polystyrene.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-07 | 1985-06-08 | 1985-12-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-07 | 1989-06-08 | 1989-12-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-07 | 1993-06-08 | 1993-12-08 | $7700.00 | Window Closed / Lapsed |