Patent US4303676A successfully refreshed from Google Patents.
US4303676A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hyaluronate based compositions and cosmetic formulations containing same
Assignee: Individual
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Filing: 1980-03-21
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Granted: 1981-12-01
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Expires: 2000-03-21
Abstract
Abstract A water based, viscoelastic composition for use in cosmetic formulations comprising, (a) a mixture of sodium hyalfractions having different molecular weights, (b) protein which is derived from the natural material from which the hyaluronate is obtained, and (c) water. Also disclosed are cosmetic formulations comprising about 0.05-5.0% of the above composition together with an emollient, a sugar alcohol, a neutral or anionic polysaccharide, a preservative, bacteriostatic and fungistatic substance which does not react with or degrade hyaluronic acid, and water.
Inventors
- 👤 Endre A. Balazs
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:02
CPC Classifications
A; A61; A61Q; A61Q19/00; A61Q19/08; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61K8/72; A61K8/73; A61K8/735; C; C08; C08L; C08L5/00; C08L5/08
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
91 words
A water based, viscoelastic composition comprising, by weight, (a) a mixture of different sodium hyaluronate fractions, a first such fraction having a molecular weight of about 10,000 to 200,000 and a second fraction having a molecular weight of about 1×10 6 to 4.5×10 6 , the ratio of said fractions being in the range of about 0.3-2:1, (b) about 50 to 400% of protein based on the weight of ingredient (a), said protein being derived from the natural material from which the hyaluronate is obtained, and (c) the balance being water.
Claim 2
Dependent Claim
91 words
A water based, viscoelastic composition comprising, by weight, (a) a mixture of different sodium hyaluronate fractions, a first such fraction having a molecular weight of about 10,000 to 200,000 and a second fraction having a molecular weight of about 1×10 6 to 4.5×10 6 , the ratio of said fractions being in the range of about 0.3-2:1, (b) about 50 to 400% of protein based on the weight of ingredient (a), said protein being derived from the natural material from which the hyaluronate is obtained, and (c) the balance being water.
Claim 3
Dependent Claim
12 words
A composition according to claim 1 having a pH of about 6-7.5.
Claim 4
Dependent Claim
20 words
A composition according to claim 1 and further comprising sufficient concentrated hydrochloric acid to lower the pH to about 2.5.
Claim 5
Dependent Claim
12 words
A composition according to claim 1 wherein the water is distilled water.
Claim 6
Dependent Claim
62 words
A cosmetic formulation comprising, by weight, about 0.05-5.0% of the composition as claimed in claim 1, about 1-5% of an emollient, about 1-5% of a sugar alcohol, about 0.2-1% of a neutral or anionic polysaccharide, about 0.05-2% of a preservative, bacteriostatic and fungistatic substance which does not react with or degrade hyaluronic acid, the balance to make up 100% being distilled water.
Claim 7
Dependent Claim
16 words
A formulation according to claim 5 wherein the emollient is squalene, isopropyl myristate or isopropyl linoleate.
Claim 8
Dependent Claim
14 words
A formulation according to claim 5 wherein the sugar alcohol is sorbitol or mannitol.
Claim 9
Dependent Claim
19 words
A formulation according to claim 5 wherein the neutral or anionic polysaccharide is methylated carboxycellulose, pectin, alginate or carageenin.
Claim 10
Dependent Claim
19 words
A formulation according to claim 5 when the preservative substance is propyl p-hydroxybenzoate or any other water soluble hydroxybenzoate.
Claim 11
Dependent Claim
11 words
A formulation according to claim 5 and further comprising a fragrance.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-30 | 1985-06-01 | 1985-12-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-30 | 1989-06-01 | 1989-12-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-30 | 1993-06-01 | 1993-12-01 | $7700.00 | Window Closed / Lapsed |