Patent US4303671A successfully refreshed from Google Patents.
US4303671A
Expired / Lapsed
US
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Albumin stabilized prostacyclin
Assignee: Pharmacia and Upjohn Co
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Filing: 1980-07-10
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Granted: 1981-12-01
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Expires: 2000-07-10
Abstract
Abstract The present invention provides novel formulations of prostacyclin suitable for parenteral administration and methods for making and using these formulations. These novel formulations include a pharmaceutically acceptable stabilizing concentration of albumin as a constituent thereof. Such novel formulations of prostacyclin are useful for its conventional pharmacological and therapeutical purposes, most to inhibition of blood platelet aggregation.
Inventors
- 👤 Francis A. Fitzpatrick
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 21:48
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/34; A61K47/00; A61K47/30; A61K47/42
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
50 words
In a method consisting essentially of administering prostacyclin to a mammal in a formulation suitable for parenteral administration, the improvement which comprises: employing as an excipient in said formulation in a pharmaceutically acceptable, stabilizing concentration albumin derived from serum obtained from the species of which said mammal is a member.
Claim 2
Dependent Claim
50 words
In a method consisting essentially of administering prostacyclin to a mammal in a formulation suitable for parenteral administration, the improvement which comprises: employing as an excipient in said formulation in a pharmaceutically acceptable, stabilizing concentration albumin derived from serum obtained from the species of which said mammal is a member.
Claim 3
Dependent Claim
46 words
In a composition consisting essentially of a formulation of prostacyclin suitable for parenteral administration, the improvement which comprises: albumin derived from serum obtained from the species of which said mammal is a member, employed as an excipient in said formulation in a pharmaceutically acceptable, stabilizing concentration.
Claim 4
Dependent Claim
46 words
In a composition consisting essentially of a formulation of prostacyclin suitable for parenteral administration, the improvement which comprises: albumin derived from serum obtained from the species of which said mammal is a member, employed as an excipient in said formulation in a pharmaceutically acceptable, stabilizing concentration.
Claim 5
Independent Claim
90 words
A method of stabilizing prostacyclin in a formulation suitable for parenteral administration to a mammal, which comprises (1) preparing a conventional pharmaceutical diluent for said formulation, (2) adding to said conventional diluent a pharmaceutically acceptable, stabilizing concentration of albumin derived from serum obtained from the species of which said mammal is a member, thereby preparing a stabilizing diluent, and (3) combining with a quantity of said stabilizing diluent an amount of a pharmacologically acceptable salt of prostacyclin whereby a predetermined, pharmaceutically-acceptable concentration of prostacyclin is obtained in the resulting solution.
Claim 6
Independent Claim
90 words
A method of stabilizing prostacyclin in a formulation suitable for parenteral administration to a mammal, which comprises (1) preparing a conventional pharmaceutical diluent for said formulation, (2) adding to said conventional diluent a pharmaceutically acceptable, stabilizing concentration of albumin derived from serum obtained from the species of which said mammal is a member, thereby preparing a stabilizing diluent, and (3) combining with a quantity of said stabilizing diluent an amount of a pharmacologically acceptable salt of prostacyclin whereby a predetermined, pharmaceutically-acceptable concentration of prostacyclin is obtained in the resulting solution.
Claim 7
Dependent Claim
96 words
A formulation of prostacyclin suitable for parenteral administration to a mammal, which comprises: (1) a quantity of a conventional pharmaceutical diluent for said formulation, (2) an amount of albumin derived from serum obtained from the species of which said mammal is a member, which when combined with said quantity of conventional diluent yields a stabilizing diluent wherein said albumin is present in a pharmaceutically acceptable, stabilizing concentration; and (3) an amount of a pharmacologically acceptable salt of prostacyclin, which when combined with said stabilizing diluent yields a predetermined, pharmaceutically-acceptable concentration of prostacyclin in the resulting solution.
Claim 8
Dependent Claim
96 words
A formulation of prostacyclin suitable for parenteral administration to a mammal, which comprises: (1) a quantity of a conventional pharmaceutical diluent for said formulation, (2) an amount of albumin derived from serum obtained from the species of which said mammal is a member, which when combined with said quantity of conventional diluent yields a stabilizing diluent wherein said albumin is present in a pharmaceutically acceptable, stabilizing concentration; and (3) an amount of a pharmacologically acceptable salt of prostacyclin, which when combined with said stabilizing diluent yields a predetermined, pharmaceutically-acceptable concentration of prostacyclin in the resulting solution.
References Cited (Backward Citations)
DE2819447A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-30 | 1985-06-01 | 1985-12-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-30 | 1989-06-01 | 1989-12-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-30 | 1993-06-01 | 1993-12-01 | $7700.00 | Window Closed / Lapsed |