Pyrazolo[1,5-c]quinazoline derivatives and analgesic compositions containing them

Abstract

Abstract The invention relates to novel pyrazolo[1,5-c]quinazoline derivatives of the general formula I ##STR1## wherein R represents a hydrogen atom, a C 1-4 alkyl group or an acyl group, R 1 represents a hydrogen atom, a C 1-12 alkyl group, a C 3-8 cycloalkyl group, a C 2-4 alkenyl group, an aralkyl group, wherein the alkyl group has 1 to 4 carbon atoms, a phenylalkenyl group, wherein the alkenyl group has 2 to 4 carbon atoms, furthermore a carboxy group or a phenyl group optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxy, C 1-4 alkoxy, nitro or di(C 1-4 alkyl)amino groups, or R and R 1 may form together a valence bond, R 2 represents a hydrogen atom, a C 1-4 alkyl or a phenyl group, or R 1 and R 2 may form together a C 2-7 alkylene group, R 3 represents a nitro group, an amino group, an alkylamino group, a dialkylamino group, wherein the alkyl groups have 1 to 4 carbon atoms, an alkylideneimino group, wherein the alkylidene group has 1 to 4 carbon atoms, a benzylideneimino group or an acylamino group, and pharmaceutically acceptable acid addition salts thereof. The novel compounds of the general formula I can be employed primarily as analgesic agents.

Inventors

• 👤 Edit Berenyi nee Poldermann
• 👤 Eniko Szirt nee Kiszelly
• 👤 Peter Gorog
• 👤 Lujza Petocz
• 👤 Ibolya Kosoczky
• 👤 Agnes Kovacs nee Palotai
• 👤 Gabriella rmos nee Lassu

Bibliographic Details