US4110452A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pyrazolo (1,5-c) quinazoline derivatives and related compounds
Assignee: ER Squibb and Sons LLC
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Filing: 1977-10-17
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Granted: 1978-08-29
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Expires: 1997-10-17
Abstract
Abstract Compounds are provided having the structure ##STR1## wherein R 1 is alkylamino, dialkylamino, or ##STR2## wherein alkyl in the above groups contains 1 to 4 carbons; R 2 is alkylamino, dialkylamino or ##STR3## wherein alkyl in the above groups contains 1 to 4 carbons; at least one of R 1 and R 2 being alkylamino or dialkylamino; R 3 is hydrogen, lower alkyl, benzyl or phenyl (optionally substituted with R 8 ), or ##STR4## (wherein R 6 is amino, alkylamino or dialkylamino, and R 7 is alkyl); and R 4 , R 5 and R 8 are the same or different and represent hydrogen, lower alkyl, lower alkoxy, alkanoyloxy, benzyloxy, hydroxy, halogen (Cl, Br and F), nitro and trifluoromethyl.
Inventors
- 👤 George C. Rovnyak
- 👤 B. Richard Vogt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 06:22
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
171 words
Compounds of the structure ##STR35## wherein R 1 is alkylamino, dialkylamino, or ##STR36## R 2 is alkylamino, dialkylamino, or ##STR37## the alkyl moiety in the above R 1 and R 2 groups having from 1 to 8 carbons; R 3 is hydrogen, lower alkyl, benzyl, phenyl or phenyl substituted by a single R 8 radical, ##STR38## (wherein R 6 is amino, alkylamino having 1 to 4 carbons, or dialkylamino having 1 to 4 carbons in each alkyl, and R 7 is alkyl of 1 to 4 carbons), with the proviso that at least one of R 1 or R 2 is alkylamino or dialkylamino; p1 R 4 , R 5 and R 8 may be the same or different and are hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, hydroxy, alkanoyloxy of 2 to 5 carbons, ##STR39## (wherein X 1 is hydrogen, lower alkoxy of 1 to 4 carbons), hydroxy, Cl, F, Br, CF 3 or NO 2 , and physiologically acceptable salts thereof.
Claim 2
Dependent Claim
171 words
Compounds of the structure ##STR35## wherein R 1 is alkylamino, dialkylamino, or ##STR36## R 2 is alkylamino, dialkylamino, or ##STR37## the alkyl moiety in the above R 1 and R 2 groups having from 1 to 8 carbons; R 3 is hydrogen, lower alkyl, benzyl, phenyl or phenyl substituted by a single R 8 radical, ##STR38## (wherein R 6 is amino, alkylamino having 1 to 4 carbons, or dialkylamino having 1 to 4 carbons in each alkyl, and R 7 is alkyl of 1 to 4 carbons), with the proviso that at least one of R 1 or R 2 is alkylamino or dialkylamino; p1 R 4 , R 5 and R 8 may be the same or different and are hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, hydroxy, alkanoyloxy of 2 to 5 carbons, ##STR39## (wherein X 1 is hydrogen, lower alkoxy of 1 to 4 carbons), hydroxy, Cl, F, Br, CF 3 or NO 2 , and physiologically acceptable salts thereof.
Claim 3
Dependent Claim
13 words
The compound of claim 1 wherein R 1 or R 2 is alkylamino.
Claim 4
Dependent Claim
13 words
The compound of claim 1 wherein R 1 or R 2 is dialkylamino.
Claim 5
Dependent Claim
10 words
The compound of claim 1 wherein R 1 is alkylamino.
Claim 6
Dependent Claim
10 words
The compound of claim 1 wherein R 1 is dialkylamino.
Claim 7
Dependent Claim
13 words
The compound of claim 1 wherein R 1 or R 2 is ##STR40##
Claim 8
Dependent Claim
10 words
The compound of claim 1 wherein R 2 is ##STR41##
Claim 9
Dependent Claim
25 words
The compound of claim 1 wherein R 3 is hydrogen, lower alkyl, benzyl or phenyl and R 1 or R 2 is alkylamino or dialkylamino.
Claim 10
Dependent Claim
23 words
The compound of claim 1 wherein R 3 is ##STR42## wherein R 6 is amino, alkylamino or dialkylamino and R 7 is alkyl.
Claim 11
Dependent Claim
16 words
The compound of claim 1 wherein R 3 , R 4 and R 5 are hydrogen.
Claim 12
Dependent Claim
12 words
The compound of claim 1 having the name 1-(diethylamino)-6-[1-(diethylamino)-3-methoxy-3-oxo-1-propenyl]-5,6-dihydro-5-oxo-pyrazolo[1,5-c]quinazoline-2-carboxylic acid, methyl ester.
Claim 13
Dependent Claim
27 words
A pharmaceutical composition for use in treating allergic conditions comprising a therapeutic amount of a compound as defined in claim 1 and a pharmaceutically acceptable carrier therefor.
Claim 14
Dependent Claim
26 words
A method for treating allergic conditions in mammals, which comprises administering to the mammalian host a therapeutic amount of a compound as defined in claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-08-28 | 1982-02-27 | 1982-08-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-08-28 | 1986-02-27 | 1986-08-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-08-28 | 1990-02-27 | 1990-08-29 | $7700.00 | Window Closed / Lapsed |