US4302447A
Expired / Lapsed
US
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Pharmaceutical and dietary composition
Assignee: Efamol Ltd
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Filing: 1979-10-30
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Granted: 1981-11-24
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Expires: 1999-10-30
Abstract
Abstract Compositions and use of γ-linolenic acids and related materials alone or with zinc and or β-lactam antibiotics to treat schizophrenia, obesity, menstrual disorders, skin disorders and other conditions, and β-lactam antibiotics alone to treat schizophrenia.
Inventors
- 👤 David F. Horrobin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 04:51
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/54; A61K31/542; A61K31/545; A61K31/41; A61K31/425; A61K31/429; A61K31/43; A61K33/00; A61K33/24; A61K33/30
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
79 words
A pharmaceutical or dietary composition for administration to influence the balance of 1-series and 2-series PG's in the body in favor of 1-series PG's, said composition comprising: (a) γ-linolenic acid or physiologically functional derivative thereof and/or dihomo-γ-linolenic acid or physiologically functional derivative thereof present in an amount of from about 0.05 to 10 grams calculated as linolenic acid, and (b) form about 0.5 to 3 grams of a β-lactam antiobiotic, alone or in an acceptable pharmaceutical or dietary vehicle.
Claim 2
Dependent Claim
79 words
A pharmaceutical or dietary composition for administration to influence the balance of 1-series and 2-series PG's in the body in favor of 1-series PG's, said composition comprising: (a) γ-linolenic acid or physiologically functional derivative thereof and/or dihomo-γ-linolenic acid or physiologically functional derivative thereof present in an amount of from about 0.05 to 10 grams calculated as linolenic acid, and (b) form about 0.5 to 3 grams of a β-lactam antiobiotic, alone or in an acceptable pharmaceutical or dietary vehicle.
Claim 3
Dependent Claim
17 words
The composition of claim 1, wherein the antibiotic is a natural or semi-synthetic penicillin or cephalosporin antibiotic.
Claim 4
Dependent Claim
24 words
The composition of claim 1, wherein the antibiotic is selected from penicillin G, penicillin N, penicillin V, cephalothin, ampicillin, amoxycillin, cloxacillin, cephalexin and cephaloglycin.
Claim 5
Dependent Claim
39 words
The composition of claim 1, presented for administration in doses comprising 0.1 to 5 g of (a) calculated as linolenic acid and 0.5 to 3 g of (b), or one half one third or one quarter of said amounts.
Claim 6
Dependent Claim
39 words
The composition of claim 1, presented for administration in doses comprising 0.1 to 2 g of (a) calculated as linolenic acid and 0.5 to 3 g of (b), or one half one third or one quarter of said amounts.
Claim 7
Dependent Claim
39 words
The composition of claim 1, presented for administration in doses comprising 0.1 to 1 g of (a) calculated as linolenic acid and 0.5 to 3 g of (b), or one half one third or one quarter of said amounts.
Claim 8
Dependent Claim
94 words
A pharmaceutical or dietary composition for administration to influence the balance of 1-series and 2-series PG's in the body in favor of 1-series PG's, said composition comprising: (a) γ-linolenic acid or physiologically functional derivative thereof and/or dihomo-γ-linolenic acid or physiologically functional derivative thereof, said acid and/or derivative present in an amount of from about 0.05 to 10 grams calculated as linolenic acid, (b) a conjoint amount of about 2.5 to 800 mg of physiologically assimilable zinc calculated as the metal, and (c) a β-lactam antibiotic, alone or in an acceptable pharmaceutical or dietary vehicle.
Claim 9
Dependent Claim
94 words
A pharmaceutical or dietary composition for administration to influence the balance of 1-series and 2-series PG's in the body in favor of 1-series PG's, said composition comprising: (a) γ-linolenic acid or physiologically functional derivative thereof and/or dihomo-γ-linolenic acid or physiologically functional derivative thereof, said acid and/or derivative present in an amount of from about 0.05 to 10 grams calculated as linolenic acid, (b) a conjoint amount of about 2.5 to 800 mg of physiologically assimilable zinc calculated as the metal, and (c) a β-lactam antibiotic, alone or in an acceptable pharmaceutical or dietary vehicle.
Claim 10
Dependent Claim
17 words
The composition of claim 7, wherein the antibiotic is a natural or semi-synthetic penicillin or cephalosporin antibiotic.
Claim 11
Dependent Claim
24 words
The composition of claim 7, wherein the antibiotic is selected from penicillin G, penicillin N, penicillin V, cephalothin, ampicillin, amoxycillin, cloxacillin, cephalexin and cephaloglycin.
Claim 12
Dependent Claim
32 words
The composition of claim 4, presented for adminstration in doses further comprising (c) 10 to 200 mg assimilable zinc calculated as the metal, or one half one third or one quarter thereof.
Claim 13
Dependent Claim
32 words
The composition of claim 5, presented for administration in doses further comprising (c) 10 to 200 mg assimilable zinc calculated as the metal, or one half one third or one quarter thereof.
Claim 14
Dependent Claim
32 words
The composition of claim 6, presented for administration in doses further comprising (c) 10 to 200 mg assimilable zinc calculated as the metal, or one half one third or one quarter thereof.
Claim 15
Dependent Claim
31 words
The composition of claim 10, 11 or 12, wherein the amount of (c) is 10 to 80 mg calculated as the metal, or one half one third or one quarter thereof.
Claim 16
Independent Claim
73 words
A method of treating schizophrenia comprising administering to a person suffering therefrom an effective amount of a pharmaceutical or dietary composition containing (a) γ-linolenic acid or physiologically functional derivative thereof and/or dihomo-γ-linolenic acid or physiologically functional derivative thereof, and (b) a conjoint amount of a further material influencing the 1-series/2-series PG balance in the body in favor of 1-series PGs, said composition being administered alone or in an acceptable pharmaceutical or dietary vehicle.
Claim 17
Independent Claim
73 words
A method of treating schizophrenia comprising administering to a person suffering therefrom an effective amount of a pharmaceutical or dietary composition containing (a) γ-linolenic acid or physiologically functional derivative thereof and/or dihomo-γ-linolenic acid or physiologically functional derivative thereof, and (b) a conjoint amount of a further material influencing the 1-series/2-series PG balance in the body in favor of 1-series PGs, said composition being administered alone or in an acceptable pharmaceutical or dietary vehicle.
References Cited (Backward Citations)
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Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-23 | 1985-05-25 | 1985-11-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-23 | 1989-05-25 | 1989-11-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-23 | 1993-05-25 | 1993-11-24 | $7700.00 | Window Closed / Lapsed |