US4034099A
Expired / Lapsed
US
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Compositions and method for treating mastitis in milk animals
Assignee: Pharmacia and Upjohn Co
•
Filing: 1975-09-02
•
Granted: 1977-07-05
•
Expires: 1995-09-02
Abstract
Abstract Compositions and methods for treating mastitis in milk animals which comprises administering by intramammary infusion an effective amount of an anti-mastitis medicament dispersed in a vehicle comprising an oil, a fatty acid ester and, optionally, a fatty acid salt.
Inventors
- 👤 Jack T. Bryan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 15:15
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0041
Claims Analysis
Total Claims: 58
Claim 1
Independent Claim
142 words
A method of treating mastitis in milk animals which comprises administering to the affected mammary region by intramammary infusion a composition which comprises an effective amount of an anti-mastitis medicament dispersed in a gelled vehicle for carrying said anti-mastitis medicament comprising a vegetable oil acceptable for intramammary infusion selected from the group consisting of non-drying, semi-drying, and drying oils and blends thereof; and from about 0.5% to 5.0% by weight of said oil of a fatty acid ester formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of glycerin, propylene glycol, mono- and dihydric alcohols of from one to twelve carbon atoms, inclusive, and polyethylene glycols having a molecular weight of between about 200 and about 6000.
Claim 2
Independent Claim
142 words
A method of treating mastitis in milk animals which comprises administering to the affected mammary region by intramammary infusion a composition which comprises an effective amount of an anti-mastitis medicament dispersed in a gelled vehicle for carrying said anti-mastitis medicament comprising a vegetable oil acceptable for intramammary infusion selected from the group consisting of non-drying, semi-drying, and drying oils and blends thereof; and from about 0.5% to 5.0% by weight of said oil of a fatty acid ester formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of glycerin, propylene glycol, mono- and dihydric alcohols of from one to twelve carbon atoms, inclusive, and polyethylene glycols having a molecular weight of between about 200 and about 6000.
Claim 3
Dependent Claim
15 words
The method as defined in claim 1 in which the vegetable oil is peanut oil.
Claim 4
Dependent Claim
16 words
The method as defined in claim 1 in which the fatty acid ester is glyceryl monostearate.
Claim 5
Dependent Claim
23 words
The method as defined in claim 1 in which the vegetable oil is peanut oil and the fatty acid ester is glyceryl monostearate.
Claim 6
Dependent Claim
25 words
The method as defined in claim 4 in which the glyceryl monostearate is present in an amount of about 2% by weight of said oil.
Claim 7
Dependent Claim
28 words
The method as defined in claim 1 in which the vegetable oil is peanut oil, the fatty acid ester is glyceryl monostearate and the anti-mastitis medicament is penicillin.
Claim 8
Dependent Claim
25 words
The method as defined in claim 6 in which the glyceryl monostearate is present in an amount of about 2% by weight of said oil.
Claim 9
Dependent Claim
68 words
The method as defined in claim 1 in which said vehicle, in addition, contains from about 0.02% to 0.50% by weight of said oil of a fatty acid salt formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of sodium, potassium and lithium.
Claim 10
Dependent Claim
15 words
The method as defined in claim 8 in which the vegetable oil is peanut oil.
Claim 11
Dependent Claim
16 words
The method as defined in claim 8 in which the fatty acid ester is glyceryl monostearate.
Claim 12
Dependent Claim
16 words
The method as defined in claim 8 in which the fatty acid salt is potassium stearate.
Claim 13
Dependent Claim
30 words
The method as defined in claim 8 in which the vegetable oil is peanut oil, the fatty acid ester is glyceryl monostearate and the fatty acid salt is potassium stearate.
Claim 14
Dependent Claim
28 words
The method as defined in claim 12 in which the potassium stearate is present in an amount of from about 0.02% to 0.15% by weight of said oil.
Claim 15
Dependent Claim
35 words
The method as defined in claim 8 in which the vegetable oil is peanut oil, the fatty acid ester is glyceryl monostearate, the fatty acid salt is potassium stearate, and the anti-mastitis medicament is penicillin.
Claim 16
Dependent Claim
46 words
The method as defined in claim 14 in which the glyceryl monostearate is present in an amount of about 2% by weight of said oil and the potassium stearate is present in an amount of from about 0.16% to about 0.20% by weight of said oil.
Claim 17
Dependent Claim
147 words
A composition for treating mastitis in milk animals by intramammary infusion which comprises an effective amount of an anti-mastitis medicament dispersed in a gelled vehicle for carrying said anti-mastitis medicament comprising a vegetable oil acceptable for intramammary infusion selected from the group consisting of non-drying, semi-drying, and drying oils and blends of non-drying oils and an oil selected from the group consisting of semi-drying and drying oils; and from about 0.5% to 5.0% by weight of said oil of a fatty acid ester formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of glycerin, propylene glycol, mono- and dihydric alcohols of from one to twelve carbon atoms, inclusive, and polyethylene glycols having a molecular weight of between about 200 and about 6000.
Claim 18
Dependent Claim
147 words
A composition for treating mastitis in milk animals by intramammary infusion which comprises an effective amount of an anti-mastitis medicament dispersed in a gelled vehicle for carrying said anti-mastitis medicament comprising a vegetable oil acceptable for intramammary infusion selected from the group consisting of non-drying, semi-drying, and drying oils and blends of non-drying oils and an oil selected from the group consisting of semi-drying and drying oils; and from about 0.5% to 5.0% by weight of said oil of a fatty acid ester formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of glycerin, propylene glycol, mono- and dihydric alcohols of from one to twelve carbon atoms, inclusive, and polyethylene glycols having a molecular weight of between about 200 and about 6000.
Claim 19
Dependent Claim
15 words
The composition as defined in claim 16 in which the vegetable oil is peanut oil.
Claim 20
Dependent Claim
16 words
The composition as defined in claim 16 in which the fatty acid ester is glyceryl monostearate.
Claim 21
Dependent Claim
23 words
The composition as defined in claim 16 in which the vegetable oil is peanut oil and the fatty acid ester is glyceryl monostearate.
Claim 22
Dependent Claim
25 words
The composition as defined in claim 19 in which the glyceryl monostearate is present in an amount of about 2% by weight of said oil.
Claim 23
Dependent Claim
28 words
The composition as defined in claim 16 in which the vegetable oil is peanut oil, the fatty acid ester is glyceryl monostearate and the anti-mastitis medicament is penicillin.
Claim 24
Dependent Claim
25 words
The composition as defined in claim 21 in which the glyceryl monostearate is present in an amount of about 2% by weight of said oil.
Claim 25
Dependent Claim
68 words
A composition as defined in claim 16 in which said vehicle, in addition, contains from about 0.02% to 0.50% by weight of said oil of a fatty acid salt formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of sodium potassium and lithium.
Claim 26
Dependent Claim
16 words
The composition as defined in claim 23 in which the fatty acid ester is glyceryl monostearate.
Claim 27
Dependent Claim
16 words
The composition as defined in claim 23 in which the fatty acid salt is potassium stearate.
Claim 28
Dependent Claim
30 words
The composition as defined in claim 23 in which the vegetable oil is peanut oil, the fatty acid ester is glyceryl monostearate and the fatty acid salt is potassium stearate.
Claim 29
Dependent Claim
28 words
The composition as defined in claim 26 in which the potassium stearate is present in an amount of from about 0.02% to 0.15% by weight of said oil.
Claim 30
Dependent Claim
35 words
The composition as defined in claim 23 in which the vegetable oil is peanut oil, the fatty acid ester is glyceryl monostearate, the fatty acid ester is potassium stearate, and the anti-mastitis medicament is penicillin.
Claim 31
Dependent Claim
46 words
The composition as defined in claim 28 in which the glyceryl monostearate is present in an amount of about 2% by weight of said oil and the potassium stearate is present in an amount of from about 0.16% to about 0.20% by weight of said oil.
Claim 32
Independent Claim
124 words
A method of treating mastitis in milk animals which comprises administering to the affected mammary region by intramammary infusion a composition which comprises an effective amount of an anti-mastitis medicament dispersed in a gelled vehicle for carrying said anti-mastitis medicament comprising a mineral oil and from about 0.5% to 5.0% by weight of said oil of a fatty acid ester formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of glycerin, propylene glycol, mono- and dihydric alcohols of from one to twelve carbon atoms, inclusive, and polyethylene glycols having a molecular weight of between about 200 and about 6000.
Claim 33
Independent Claim
124 words
A method of treating mastitis in milk animals which comprises administering to the affected mammary region by intramammary infusion a composition which comprises an effective amount of an anti-mastitis medicament dispersed in a gelled vehicle for carrying said anti-mastitis medicament comprising a mineral oil and from about 0.5% to 5.0% by weight of said oil of a fatty acid ester formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of glycerin, propylene glycol, mono- and dihydric alcohols of from one to twelve carbon atoms, inclusive, and polyethylene glycols having a molecular weight of between about 200 and about 6000.
Claim 34
Dependent Claim
68 words
The method as defined in claim 30 in which said vehicle, in addition, contains from about 0.02% to 0.50% by weight of said oil of a fatty acid salt formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of sodium, potassium and lithium.
Claim 35
Independent Claim
155 words
A method for reducing the amount of time required for an anti-mastitis medicament to clear the udder of a milk animal after the last intramammary infusion of said anti-mastitis medicament which comprises administering by intramammary infusion an effective amount of an anti-mastitis medicament dispersed in a gelled vehicle for carrying said anti-mastitis medicament which comprises: a. a vegetable oil acceptable for intramammary infusion selected from the group consisting of non-drying, semi-drying, and drying oils and blends thereof; and b. from about 0.5% to 5.0% by weight of a fatty acid ester formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxlyic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of glycerin, propylene glycol, mono- and dihydric alcohols of from one to twelve carbon atoms, inclusive, and polyethylene glycols having a molecular weight of between about 200 and about 6000.
Claim 36
Independent Claim
155 words
A method for reducing the amount of time required for an anti-mastitis medicament to clear the udder of a milk animal after the last intramammary infusion of said anti-mastitis medicament which comprises administering by intramammary infusion an effective amount of an anti-mastitis medicament dispersed in a gelled vehicle for carrying said anti-mastitis medicament which comprises: a. a vegetable oil acceptable for intramammary infusion selected from the group consisting of non-drying, semi-drying, and drying oils and blends thereof; and b. from about 0.5% to 5.0% by weight of a fatty acid ester formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxlyic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of glycerin, propylene glycol, mono- and dihydric alcohols of from one to twelve carbon atoms, inclusive, and polyethylene glycols having a molecular weight of between about 200 and about 6000.
Claim 37
Dependent Claim
14 words
The method as defined claim claim 32 in which the anti-mastitis medicament is penicillin.
Claim 38
Dependent Claim
68 words
The method as defined in claim 32 in which said vehicle, in addition, contains from about 0.02% to 0.50% by weight of said oil of a fatty acid salt formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of sodium potassium and lithium.
Claim 39
Dependent Claim
14 words
The method as defined in claim 34 in which the anti-mastitis medicament is penicillin.
Claim 40
Independent Claim
137 words
A method for reducing the amount of time required for an anti-mastitis medicament to clear the udder of a milk animal after the last intramammary infusion of said anti-mastitis medicament which comprises administering by intramammary infusion an effective amount of an anti-mastitis medicament dispersed in a gelled vehicle for carrying said anti-mastitis medicament which comprises: a. a mineral oil; and b. from about 0.5% to 5.0% by weight of a fatty acid ester formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of glycerin, propylene glycol, mono- and dihydric alcohols of from one to twelve carbon atoms, inclusive, and polyethylene glycols having a molecular weight of between about 200 and about 6000.
Claim 41
Independent Claim
137 words
A method for reducing the amount of time required for an anti-mastitis medicament to clear the udder of a milk animal after the last intramammary infusion of said anti-mastitis medicament which comprises administering by intramammary infusion an effective amount of an anti-mastitis medicament dispersed in a gelled vehicle for carrying said anti-mastitis medicament which comprises: a. a mineral oil; and b. from about 0.5% to 5.0% by weight of a fatty acid ester formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of glycerin, propylene glycol, mono- and dihydric alcohols of from one to twelve carbon atoms, inclusive, and polyethylene glycols having a molecular weight of between about 200 and about 6000.
Claim 42
Dependent Claim
68 words
The method as defined in claim 36 in which said vehicle, in addition, contains from about 0.02% to 0.50% by weight of said oil of a fatty acid salt formed from a fatty acid selected from the group consisting of long chain saturated and unsaturated monocarboxylic acids having from twelve to twenty carbon atoms, inclusive, and a member selected from the group consisting of sodium, potassium and lithium.
Claim 43
Independent Claim
75 words
A method of treating mastitis in milk animals which comprises administering to the affected mammary region by intramammary infusion a composition which comprises an effective amount of an anti-mastitis medicament dispersed in a vehicle for carrying said anti-mastitis medicament comprising a vegetable oil acceptable for intramammary infusion selected from the group consisting of non-drying, semi-drying, and drying oils and blends thereof; gelled with from about 0.5% to 5.0% by weight of said oil of Tegin.
Claim 44
Independent Claim
75 words
A method of treating mastitis in milk animals which comprises administering to the affected mammary region by intramammary infusion a composition which comprises an effective amount of an anti-mastitis medicament dispersed in a vehicle for carrying said anti-mastitis medicament comprising a vegetable oil acceptable for intramammary infusion selected from the group consisting of non-drying, semi-drying, and drying oils and blends thereof; gelled with from about 0.5% to 5.0% by weight of said oil of Tegin.
Claim 45
Dependent Claim
15 words
The method as defined in claim 38 in which the vegetable oil is peanut oil.
Claim 46
Dependent Claim
24 words
The method as defined in claim 39 in which the Tegin is present in an amount of about 2% by weight of said oil.
Claim 47
Dependent Claim
14 words
The method as defined in claim 39 in which the anti-mastitis medicament is penicillin.
Claim 48
Dependent Claim
24 words
The method as defined in claim 41 in which the Tegin is present in an amount of about 2% by weight of said oil.
Claim 49
Dependent Claim
16 words
The method as defined in claim 39 in which the anti-mastitis medicament is procaine penicillin G.
Claim 50
Dependent Claim
24 words
The method as defined in claim 43 in which the Tegin is present in an amount of about 2% by weight of said oil.
Claim 51
Dependent Claim
80 words
A composition for treating mastitis in milk animals by intramammary infusion which comprises an effective amount of an anti-mastitis medicament dispersed in a vehicle for carrying said anti-mastitis medicament comprising a vegetable oil acceptable for intramammary infusion selected from the group consisting of non-drying, semi-drying, and drying oils and blends of non-drying oils and an oil selected from the group consisting of semi-drying and drying oils; gelled with from about 0.5% to 5.0% by weight of said oil of Tegin.
Claim 52
Dependent Claim
80 words
A composition for treating mastitis in milk animals by intramammary infusion which comprises an effective amount of an anti-mastitis medicament dispersed in a vehicle for carrying said anti-mastitis medicament comprising a vegetable oil acceptable for intramammary infusion selected from the group consisting of non-drying, semi-drying, and drying oils and blends of non-drying oils and an oil selected from the group consisting of semi-drying and drying oils; gelled with from about 0.5% to 5.0% by weight of said oil of Tegin.
Claim 53
Dependent Claim
15 words
The composition as defined in claim 45 in which the vegetable oil is peanut oil.
Claim 54
Dependent Claim
24 words
The composition as defined in claim 46 in which the Tegin is present in an amount of about 2% by weight of said oil.
Claim 55
Dependent Claim
14 words
The composition as defined in claim 46 in which the anti-mastitis medicament is penicillin.
Claim 56
Dependent Claim
24 words
The composition as defined in claim 48 in which the Tegin is present in an amount of about 2% by weight of said oil.
Claim 57
Dependent Claim
16 words
The composition as defined in claim 46 in which the anti-mastitis medicament is procaine penicillin G.
Claim 58
Dependent Claim
24 words
The composition as defined in claim 50 in which the Tegin is present in an amount of about 2% by weight of said oil.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-04 | 1981-01-03 | 1981-07-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-04 | 1985-01-03 | 1985-07-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-04 | 1989-01-03 | 1989-07-05 | $7700.00 | Window Closed / Lapsed |