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US4300545A Expired / Lapsed US ⏱️ 0.0 years remaining

Method and nozzle for nasal vaccination of immature mammals

Assignee: Merck Sharp & Dohme LLC
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Filing: 1980-06-23
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Granted: 1981-11-17
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Expires: 2000-06-23
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Abstract

Abstract Method and means for vaccinating a mammal using a convex nozzle with an elongated tip. The mammal's alar fold is pushed aside by the tip so that vaccine is deposited behind the alar fold. Vaccine is then dispensed through the nozzle.

Inventors

  • 👤 Robert A. Goodnow
  • 👤 Floyd J. Shade
  • 👤 Thomas A. Sloboth
  • 👤 Donald J. Kaye

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-01 19:37
CPC Classifications
A; A61; A61D; A61D7/00

Claims Analysis

Total Claims: 14
Claim 1
Independent Claim 246 words
A nasal nozzle for insertion into the nasal cavities of mammals having alar folds for introducing fluid pharmaceutical composition comprising: (a) a convex body continuously curving at radius of 0.5 to 1.0 inches from a wide portion to an apex, said convex body having an axis, the axial length of said convex body being 0.36 to 0.6 inches, the diameter of said wide portion measured perpendicular to said axis being 0.48 to 0.6 inches, (b) elongated tip means for pushing aside the alar fold of the mammal upon insertion of said nozzle into the nasal cavity projecting from said apex along said axis, said tip means having length of 0.12 to 0.24 inches and outside diameter of 0.05 to 0.20 inches, (c) a channel throughout said convex body and elongated tip means along said axis, said channel having decreasing area from a rear end of said channel to an outlet opening on an end of said elongated tip means, said outlet opening having diameter of 0.025 to 0.05 inches, said channel having non-uniform taper and having a rear section having uniform taper, an offset wherein the angle included between said offset and said axis is from 25° to 45°, and a front section having uniform taper such that the cross-sectional area of said front section decreases by 25% to 45% per 1/4 inch of front section length, and (d) adapting means for attaching said nozzle to a container for dispensing a pharmaceutical composition through said channel.
Claim 2
Dependent Claim 246 words
A nasal nozzle for insertion into the nasal cavities of mammals having alar folds for introducing fluid pharmaceutical composition comprising: (a) a convex body continuously curving at radius of 0.5 to 1.0 inches from a wide portion to an apex, said convex body having an axis, the axial length of said convex body being 0.36 to 0.6 inches, the diameter of said wide portion measured perpendicular to said axis being 0.48 to 0.6 inches, (b) elongated tip means for pushing aside the alar fold of the mammal upon insertion of said nozzle into the nasal cavity projecting from said apex along said axis, said tip means having length of 0.12 to 0.24 inches and outside diameter of 0.05 to 0.20 inches, (c) a channel throughout said convex body and elongated tip means along said axis, said channel having decreasing area from a rear end of said channel to an outlet opening on an end of said elongated tip means, said outlet opening having diameter of 0.025 to 0.05 inches, said channel having non-uniform taper and having a rear section having uniform taper, an offset wherein the angle included between said offset and said axis is from 25° to 45°, and a front section having uniform taper such that the cross-sectional area of said front section decreases by 25% to 45% per 1/4 inch of front section length, and (d) adapting means for attaching said nozzle to a container for dispensing a pharmaceutical composition through said channel.
Claim 3
Dependent Claim 14 words
The combination of the nozzle of claim 1 attached to a container of vaccine.
Claim 4
Dependent Claim 11 words
The combination of claim 2 wherein the container is a syringe.
Claim 5
Dependent Claim 24 words
The nozzle of claim 1 wherein said adapting means are adapted to fit a syringe of the type having a hub, reservoir, and plunger.
Claim 6
Independent Claim 85 words
A method of safely and effectively vaccinating a mammal haing an alar fold comprising the steps of: a. inserting into a nostril of the animal a nozzle having an elongated tip, b. pushing the mammal's alar fold aside with said elongated tip, c. dispensing a preselected amount of vaccine from a container through said nozzle while the alar fold is pushed aside by said tip such that vaccine is deposited behind the alar fold, and d. withdrawing the nozzle from the nostril of said mammal.
Claim 7
Independent Claim 85 words
A method of safely and effectively vaccinating a mammal haing an alar fold comprising the steps of: a. inserting into a nostril of the animal a nozzle having an elongated tip, b. pushing the mammal's alar fold aside with said elongated tip, c. dispensing a preselected amount of vaccine from a container through said nozzle while the alar fold is pushed aside by said tip such that vaccine is deposited behind the alar fold, and d. withdrawing the nozzle from the nostril of said mammal.
Claim 8
Dependent Claim 11 words
The method of claim 5 wherein said container is a syringe.
Claim 9
Dependent Claim 17 words
The method of claim 5 wherein the mammal is a 1 to 6 week old canine puppy.
Claim 10
Dependent Claim 16 words
The method of claim 5 wherein the mammal is a 1 to 6 week old kitten.
Claim 11
Dependent Claim 16 words
The method of claim 5 wherein the mammal is a 1 to 10 day old piglet.
Claim 12
Dependent Claim 16 words
The method of claim 5 wherein the mammal is a 4 to 10 week old rabbit.
Claim 13
Dependent Claim 11 words
The method of claim 5 wherein said vaccine is a suspension.
Claim 14
Dependent Claim 17 words
The method of claim 1 wherein said suspension has solid content of 40 to 60 weight percent.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1984-11-16 1985-05-18 1985-11-17 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1988-11-16 1989-05-18 1989-11-17 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1992-11-16 1993-05-18 1993-11-17 $7700.00 Window Closed / Lapsed

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