US4298525A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bis-indole-alkaloid
Assignee: Richter Gedeon Vegyeszeti Gyar Nyrt
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Filing: 1979-07-27
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Granted: 1981-11-03
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Expires: 1999-07-27
Abstract
Abstract A process for the preparation of diindolealkaloids, especially new compounds corresponding to vinblastine or leurosine, in which the N-methyl group is replaced by an N-CH2-OC2H5 group having antitumor properties. The starting compounds are subjected to oxidation by chromic acid or an alkali metal dichromate at temperatures from -90 DEG C. to -30 DEG C. but preferably below about -45 DEG C. when the new compounds are to be produced, ethanol being present in this case.
Inventors
- 👤 Karola Jovanovics
- 👤 Sandor Gorog
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 01:25
CPC Classifications
C; C07; C07D; C07D519/00; C07D519/04; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
100 words
A compound RGH-4451 or a pharmaceutically acceptable acid addition salt thereof wherein the compound RGH-4451 has the following characteristics: melts at 235° C. to 238° C., has a specific rotary power of [α] D 25 =+30.5°, (c=1, chloroform), has an infrared spectrum illustrated in FIG. 1, has a 1 H-NMR spectrum illustrated in FIG. 2, has a 13 C-NMR spectrum illustrated in FIG. 3, and has a molecular weight of 854.449 indicating that RGH-4451 differs from vinblastine in containing a N--CH 2 --O--C 2 H 5 group in place of an N-methyl group in the vindoline moiety of the molecule.
Claim 2
Dependent Claim
100 words
A compound RGH-4451 or a pharmaceutically acceptable acid addition salt thereof wherein the compound RGH-4451 has the following characteristics: melts at 235° C. to 238° C., has a specific rotary power of [α] D 25 =+30.5°, (c=1, chloroform), has an infrared spectrum illustrated in FIG. 1, has a 1 H-NMR spectrum illustrated in FIG. 2, has a 13 C-NMR spectrum illustrated in FIG. 3, and has a molecular weight of 854.449 indicating that RGH-4451 differs from vinblastine in containing a N--CH 2 --O--C 2 H 5 group in place of an N-methyl group in the vindoline moiety of the molecule.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-02 | 1985-05-04 | 1985-11-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-02 | 1989-05-04 | 1989-11-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-02 | 1993-05-04 | 1993-11-03 | $7700.00 | Window Closed / Lapsed |