US4189432A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N-formyl and N-desmethyl leurosine derivatives
Assignee: Richter Gedeon Vegyeszeti Gyar Nyrt
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Filing: 1973-12-05
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Granted: 1980-02-19
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Expires: 1993-12-05
Abstract
Abstract Leurosine derivatives of the formula (I), <IMAGE> (I) wherein R is hydrogen or formyl, or pharmaceutically acceptable acid addition salts thereof were prepared by oxidizing leurosine or an acid addition salt thereof, optionally formylating the thus-obtained product and then separating, and, if desired, converting any of the free bases into its acid addition salt. The new compounds of the invention possess strong cytostatic activity, and can be used in the human therapy with great advantage.
Inventors
- 👤 Karola Jovanovics
- 👤 Kalman Szasz
- 👤 Bela Kellner
- 👤 Laszlo Nemeth
- 👤 Zsuzsa Relle
- 👤 Emil Bittner
- 👤 Eszter Dezseri
- 👤 Janos Eles
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:30
CPC Classifications
C; C07; C07D; C07D519/00; C07D519/04; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
25 words
A compound selected from the group consisting of leurosine in which N-methyl is replaced by H or formyl or a pharmaceutically acceptable acid-addition salt thereof.
Claim 2
Dependent Claim
25 words
A compound selected from the group consisting of leurosine in which N-methyl is replaced by H or formyl or a pharmaceutically acceptable acid-addition salt thereof.
Claim 3
Dependent Claim
2 words
N-formyl-leurosine sulfate.
Claim 4
Dependent Claim
2 words
N-formyl-leurosine sulfate.
Claim 5
Dependent Claim
1 words
Des-N-methyl-Leurosine.
Claim 6
Dependent Claim
1 words
Des-N-methyl-Leurosine.
Claim 7
Dependent Claim
2 words
Des-N-methyl-leurosine sulfate.
Claim 8
Dependent Claim
2 words
Des-N-methyl-leurosine sulfate.
References Cited (Backward Citations)
US3392173A
Cited
US4065457A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-02-18 | 1983-08-20 | 1984-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-02-18 | 1987-08-20 | 1988-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-02-18 | 1991-08-20 | 1992-02-19 | $7700.00 | Window Closed / Lapsed |