US4298498A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Control reagent for test strips for determining urobilinogen in urine
Assignee: Roche Diagnostics GmbH
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Filing: 1979-12-13
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Granted: 1981-11-03
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Expires: 1999-12-13
Abstract
Abstract The present invention provides a control reagent for test strips for the detection of urobilinogen and possibly of other diagnostically relevant components, such as bilirubin, ketone bodies, glucose, protein, nitrite and blood, and possibly also of pH, which has a content of 2,4-dimethylpyrrole-3-carboxylic acid and/or of at least one alkali metal and/or alkaline earth metal salt thereof as control substance for urobilinogen.
Inventors
- 👤 Helmut Rehner
- 👤 Walter Rittersdorf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 19:05
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/72; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/102499; Y10T436/103332; Y10T436/104998; Y10T436/105831; Y10T436/14; Y10T436/145555; Y10T436/146666
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
82 words
An artificial human urine control reagent for analytical test strips used in analyzing human urine, comprising a mixture of a component selected from 2, 4-dimethylpyrrole-3-carboxylic acid, alkali metal salts thereof and alkaline earth metal salts thereof as a substitute for naturally occurring urobilinogen in human urine and at least one other component which is or simulates a diagnostically relevant component of human urine, the ratio of urobilinogen substitute to said other at least one component simulating conditions naturally occurring in human urine.
Claim 2
Dependent Claim
82 words
An artificial human urine control reagent for analytical test strips used in analyzing human urine, comprising a mixture of a component selected from 2, 4-dimethylpyrrole-3-carboxylic acid, alkali metal salts thereof and alkaline earth metal salts thereof as a substitute for naturally occurring urobilinogen in human urine and at least one other component which is or simulates a diagnostically relevant component of human urine, the ratio of urobilinogen substitute to said other at least one component simulating conditions naturally occurring in human urine.
Claim 3
Dependent Claim
15 words
Control reagent as claimed in claim 1 wherein said 2,4-dimethylpyrrole-3-carboxylic acid component is 2,4-dimethylpyrrole-3-carboxylic acid.
Claim 4
Dependent Claim
16 words
Control reagent as claimed in claim 1 wherein said 2,4-dimethylpyrrole-3-carboxylic acid component is in solid form.
Claim 5
Dependent Claim
16 words
Control reagent as claimed in claim 1 wherein said 2,4-dimethylpyrrole-3-carboxylic acid component is in dissolved form.
Claim 6
Dependent Claim
12 words
Control reagent as claimed in claim 1 also comprising a buffer substance.
Claim 7
Dependent Claim
17 words
Control reagent as claimed in claim 1 wherein said test strip is for the detection of urobilinogen.
Claim 8
Dependent Claim
24 words
Control reagent as claimed in claim 6 wherein said test strip is for the detection of urobilinogen and, optionally, of other diagnostically relevant components.
Claim 9
Dependent Claim
23 words
Control reagent as claimed in claim 7 wherein such other diagnostically relevant components are bilirubin, ketone bodies, glucose, protein, nitrite, blood and pH.
Claim 10
Dependent Claim
73 words
Control reagent as claimed in claim 1 comprising 0.002 to 0.4 g. 2,4-dimethylpyrrole-3-carboxylic acid, 0 to 0.1 g. bilirubin salt, 0 to 5.0 g. aluminium acetylacetonate or an equivalent amount of the corresponding magnesium or beryllium compound, 0 to 0.1 g. nitrite, 0 to 7 g. albumin, 0 to 0.1 g. haemoglobin, 0.3 to 100 g. buffer substance, pH 7.5 to 9.0, in solid or dissolved form, referred to 1 liter of solution.
Claim 11
Dependent Claim
78 words
Control reagent as claimed in claim 1 comprising 0.007 to 0.2 g. 2,4-dimethylpyrrole-3-carboxylic acid, 0 to 0.07 g. bilirubin salt, 0 to 2.0 g. aluminium acetylacetonate or an equivalent amount of the corresponding magnesium or beryllium salt, 0 to 0.01 g. nitrite, 0 to 3.0 g. albumin, 0 to 3.0 g. D(+)-glucose, 0 to 0.04 g. haemoglobin, 3 to 25 g. buffer substance, pH 7.8 to 6.5, in solid or dissolved form, referred to 1 liter of solution.
Claim 12
Dependent Claim
20 words
Control reagent as claimed in claim 1 wherein the 2,4-dimethylpyrrole-3-carboxylic acid is used in the form of its sodium salt.
Claim 13
Dependent Claim
21 words
Control reagent as claimed in claim 5 wherein the buffer substance used has a buffer capacity of 5 to 25 mMol/liter.
Claim 14
Dependent Claim
16 words
Control reagent as claimed in claim 5 wherein the buffer substance used is sodium diethylbarbiturate/diethylbarbituric acid.
Claim 15
Dependent Claim
10 words
Control reagent as claimed in claim 1 in tablet form.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-02 | 1985-05-04 | 1985-11-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-02 | 1989-05-04 | 1989-11-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-02 | 1993-05-04 | 1993-11-03 | $7700.00 | Window Closed / Lapsed |