US4038485A
Expired / Lapsed
US
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Test composition, device, and method
Assignee: Bayer Corp
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Filing: 1976-09-17
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Granted: 1977-07-26
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Expires: 1996-09-17
Abstract
Abstract A test device, test composition, and method are disclosed for determining the presence of a component in a sample. The device comprises a carrier matrix incorporated with a reactant system which produces a detectable response upon contact with the sample component. After a predetermined time interval elapses, the production of the detectable response is terminated by an inhibitor system also incorporated with the matrix. The test composition comprises the reactant and inhibitor systems. The method of use comprises contacting the test device with a test sample suspected of containing the component, permitting a predetermined time to elapse after contacting, and observing any detectable response produced.
Inventors
- 👤 Katharine Gentry Johnston
- 👤 Jerome Greyson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:05
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; Y; Y10; Y10S; Y10S436/00; Y10S436/805; Y10S436/807; Y10S436/81
Claims Analysis
Total Claims: 43
Claim 1
Independent Claim
59 words
A test composition for detecting the presence of a component in a sample comprising a. a reactant system which, upon contact with said sample, interacts with said component to produce a detectable response, and b. an inhibitor system which, upon contact with said sample, prevents said reactant system from interacting with said component after elapse of a predetermined time.
Claim 2
Dependent Claim
59 words
A test composition for detecting the presence of a component in a sample comprising a. a reactant system which, upon contact with said sample, interacts with said component to produce a detectable response, and b. an inhibitor system which, upon contact with said sample, prevents said reactant system from interacting with said component after elapse of a predetermined time.
Claim 3
Dependent Claim
15 words
The test composition of claim 1 in which said detectable response is a color change.
Claim 4
Dependent Claim
17 words
The test composition of claim 1 in which said inhibitor system comprises an ester of 2-cyanoacrylic acid.
Claim 5
Dependent Claim
14 words
The test composition of claim 1 in which said inhibitor system comprises polyvinyl alcohol.
Claim 6
Dependent Claim
23 words
The test composition of claim 1 in which said component is glucose, ketone, occult blood, bilirubin, urobilinogen, cholesterol, hydrogen ion, protein or nitrite.
Claim 7
Dependent Claim
27 words
The test composition of claim 1 in which the rate of production of said detectable response is dependent upon the amount of said component in said sample.
Claim 8
Dependent Claim
32 words
The test composition of claim 1 in which said inhibitor system terminates the production of the detectable response by undergoing a hardening or gelling reaction in competition with production of said response.
Claim 9
Dependent Claim
43 words
The test composition of claim 1 in which said inhibitor system contains a substance capable of producing heat upon contact with said sample, thereby elevating the temperature after a predetermined time, such that said reactant system is prevented from interacting with said component.
Claim 10
Dependent Claim
32 words
The test composition of claim 1 in which said inhibitor system is a poison for said reactant system after a predetermined time, thereby preventing said reactant system from interacting with said component.
Claim 11
Dependent Claim
15 words
The test composition of claim 1 in which said inhibitor system comprises a water-reactive polyisocyanate.
Claim 12
Dependent Claim
23 words
The test composition of claim 1 in which said inhibitor system comprises a material which gels or hardens on contact with said sample.
Claim 13
Dependent Claim
28 words
The test composition of claim 11 in which said material hardens or gels at a rate sufficient to inhibit further interaction between said reactant system and said component.
Claim 14
Dependent Claim
18 words
The test composition of claim 11 in which the gelling or hardening is initiated upon contact with water.
Claim 15
Dependent Claim
64 words
A test device for detecting the presence of a component in a sample comprising a carrier matrix incorporated with a. a reactant system which, upon contact with said sample, interacts with said component to produce a detectable response, and b. an inhibitor system which, upon contact with the sample, prevents the reactant system from interacting with the component after elapse of a predetermined time.
Claim 16
Dependent Claim
64 words
A test device for detecting the presence of a component in a sample comprising a carrier matrix incorporated with a. a reactant system which, upon contact with said sample, interacts with said component to produce a detectable response, and b. an inhibitor system which, upon contact with the sample, prevents the reactant system from interacting with the component after elapse of a predetermined time.
Claim 17
Dependent Claim
44 words
The test device of claim 14 in which said inhibitor system is capable of producing heat upon contact with said sample, thereby elevating the temperature of said device, after a predetermined time, such that said reactant system is prevented from interacting with said component.
Claim 18
Dependent Claim
32 words
The test device of claim 14 in which said inhibitor system is capable of poisoning said reactant system after a predetermined time, thereby preventing said reactant system from interacting with said component.
Claim 19
Dependent Claim
22 words
The test device of claim 14 in which the component is glucose, ketone, occult blood, bilirubin, urobilinogen, cholesterol, hydrogenion, protein, or nitrite.
Claim 20
Dependent Claim
15 words
The test device of claim 14 in which said detectable response is a color change.
Claim 21
Dependent Claim
27 words
The test device of claim 14 in which the rate of production of said detectable response is dependent on the amount of said component in said sample.
Claim 22
Dependent Claim
23 words
The test device of claim 14 in which said inhibitor system comprises a material which hardens or gels on contact with said sample.
Claim 23
Dependent Claim
28 words
The test device of claim 20 in which said material gels or hardens at a rate sufficient to inhibit production of said detectable response after a predetermined time.
Claim 24
Dependent Claim
17 words
The test device of claim 20 in which said material is 2-cyanoacrylic acid or an ester thereof.
Claim 25
Dependent Claim
13 words
The test device of claim 20 in which said material comprises polyvinyl alcohol.
Claim 26
Dependent Claim
21 words
The test device of claim 20 in which the gelling or hardening of said material is initiated upon contact with water.
Claim 27
Dependent Claim
14 words
The test device of claim 20 in which said material is a water-reactive polyisocyanate.
Claim 28
Independent Claim
88 words
A method for detecting the presence of a component in a sample, the method comprising; a. contacting said sample with a carrier matrix incorporated with (i) a reactant system which, upon contact with said sample, interacts with said component to produce a detectable response, and (ii) an inhibitor system which, upon contact with said sample, prevents the reactant system from interacting with the component after a predetermined time, b. incubating the matrix, after contact with the said sample, for said predetermined time, and c. observing said detectable response.
Claim 29
Independent Claim
88 words
A method for detecting the presence of a component in a sample, the method comprising; a. contacting said sample with a carrier matrix incorporated with (i) a reactant system which, upon contact with said sample, interacts with said component to produce a detectable response, and (ii) an inhibitor system which, upon contact with said sample, prevents the reactant system from interacting with the component after a predetermined time, b. incubating the matrix, after contact with the said sample, for said predetermined time, and c. observing said detectable response.
Claim 30
Dependent Claim
40 words
The method of claim 26 in which said inhibitor system produces heat upon contact with said sample, thereby elevating the temperature of said matrix, after a predetermined time, such that the reactant system is prevented from interacting with said component.
Claim 31
Dependent Claim
21 words
The method of claim 26 in which said inhibitor system is capable of poisoning said reactant system after a predetermined time.
Claim 32
Dependent Claim
22 words
The method of claim 26 in which said component is glucose, ketone, occult blood, bilirubin, urobilinogen, cholesterol, hydrogen ion, protein, or nitrite.
Claim 33
Dependent Claim
22 words
The method of claim 26 in which said inhibitor system is a material which hardens or gels upon contact with said sample.
Claim 34
Dependent Claim
16 words
The method of claim 30 in which said material is 2-cyanoacrylic acid or an ester thereof.
Claim 35
Dependent Claim
12 words
The method of claim 30 in which said material is polyvinyl alcohol.
Claim 36
Independent Claim
68 words
A method for producing a test device for detecting the presence of a component in a sample which comprises incorporating a carrier matrix with a. a reactant system which, when contacted with said sample containing said component, interacts therewith to produce a detectable response, and b. an inhibitor system which, on contact with said sample, prevents said reactant system from interacting with said component after a predetermined time.
Claim 37
Independent Claim
68 words
A method for producing a test device for detecting the presence of a component in a sample which comprises incorporating a carrier matrix with a. a reactant system which, when contacted with said sample containing said component, interacts therewith to produce a detectable response, and b. an inhibitor system which, on contact with said sample, prevents said reactant system from interacting with said component after a predetermined time.
Claim 38
Dependent Claim
25 words
The method of claim 33 wherein the rate of production of said detectable response is dependent upon the amount of said component in said sample.
Claim 39
Dependent Claim
22 words
The method of claim 33 in which said inhibitor system comprises a material which gels or hardens on contact with said sample.
Claim 40
Dependent Claim
18 words
The method of claim 33 in which said reactant and inhibitor systems are incorporated with said carrier sequentially.
Claim 41
Independent Claim
57 words
A method for producing a test device comprising incorporating with a carrier matrix having incorporated therewith a reactant system which, upon contacted with a sample containing a component whose presence is to be detected, interacts therewith to produce a color-change; an inhibitor system which, on contact with said sample, prevents said color-change production after a predetermined time.
Claim 42
Independent Claim
57 words
A method for producing a test device comprising incorporating with a carrier matrix having incorporated therewith a reactant system which, upon contacted with a sample containing a component whose presence is to be detected, interacts therewith to produce a color-change; an inhibitor system which, on contact with said sample, prevents said color-change production after a predetermined time.
Claim 43
Dependent Claim
24 words
The method of claim 37 in which the rate of said color-change production is dependent upon the amount of said component in said sample.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-25 | 1981-01-24 | 1981-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-25 | 1985-01-24 | 1985-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-25 | 1989-01-24 | 1989-07-26 | $7700.00 | Window Closed / Lapsed |