US4297362A
Expired / Lapsed
US
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4-(3,4-Diaminophenyl)pyridine or salts, and use thereof as cardiotonic
Assignee: Sanofi SA
•
Filing: 1980-07-28
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Granted: 1981-10-27
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Expires: 2000-07-28
Abstract
Abstract 4-(3,4-Diaminophenyl)pyridine, a cardiotonic agent, is prepared by reducing 4-(4-amino-3-nitrophenyl)pyridine or preferably by reacting 4-(4-acetylamino-3-nitrophenyl)pyridine or 4-(3-acetylamino-4-nitrophenyl)pyridine with stannous chloride and hydrochloric acid. 4-(3,4-diaminophenyl)pyridine or pharmaceutically-acceptable acid-addition salt thereof is disclosed as the active ingredient in a cardiotonic composition for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment.
Inventors
- 👤 George Y. Lesher
- 👤 Baldev Singh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 09:44
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/36; C07D213/40; C07D213/38
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
6 words
4-(3,4-Diaminophenyl)pyridine or pharmaceutically-acceptable acid-addition salt thereof.
Claim 2
Dependent Claim
6 words
4-(3,4-Diaminophenyl)pyridine or pharmaceutically-acceptable acid-addition salt thereof.
Claim 3
Dependent Claim
1 words
4-(3,4-Diaminophenyl)pyridine.
Claim 4
Dependent Claim
1 words
4-(3,4-Diaminophenyl)pyridine.
Claim 5
Dependent Claim
32 words
A cardiotonic composition for increasing cardiac contractility, said composition comprising a pharmaceutically-acceptable inert carrier and, as the active component thereof, an effective amount of the cardiotonic 4-(3,4-diaminophenyl)pyridine or pharmaceutically-acceptable acid-addition salt thereof.
Claim 6
Dependent Claim
32 words
A cardiotonic composition for increasing cardiac contractility, said composition comprising a pharmaceutically-acceptable inert carrier and, as the active component thereof, an effective amount of the cardiotonic 4-(3,4-diaminophenyl)pyridine or pharmaceutically-acceptable acid-addition salt thereof.
Claim 7
Dependent Claim
12 words
A composition according to claim 3 where the active component is 4-(3,4-diaminophenyl)pyridine.
Claim 8
Independent Claim
36 words
The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering parenterally in a liquid dosage form to such patient an effective amount of the cardiotonic 4-(3,4-diaminiphenyl)pyridine or pharmaceutically-acceptable acid-acceptable salt thereof.
Claim 9
Independent Claim
36 words
The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering parenterally in a liquid dosage form to such patient an effective amount of the cardiotonic 4-(3,4-diaminiphenyl)pyridine or pharmaceutically-acceptable acid-acceptable salt thereof.
References Cited (Backward Citations)
US3891656A
Cited
US3994903A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-26 | 1985-04-27 | 1985-10-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-26 | 1989-04-27 | 1989-10-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-26 | 1993-04-27 | 1993-10-27 | $7700.00 | Window Closed / Lapsed |