Male contraceptive steroids and methods of use

Claim 1

A method of effecting male contraception which comprises oral administration of a contraceptively effective amount of a comound of the formula: ##STR15## where A is a methyl, methoxy, trifluoromethyl, hydroxyl or nitro group or a hydrogen, fluorine, chlorine or bromine atom; where D is a methyl, methoxy, trifluoromethyl, hydroxyl or nitro group or a hydrogen, fluorine, chlorine or bromine atom; where M is a methyl, methoxy, trifluoromethyl, hydroxyl or nitro group or a hydrogen, fluorine, chlorine or bromine atom; where R 2 is a hydrogen atom or methyl group; where R 2 α is a hydrogen atom, alkyl 1 thru 4 carbon atoms or benzyl; where R 2 β is a hydrogen atom or methyl group with the proviso that when R 2 β is methyl, R 2 α is also methyl; where R 2 α is alkyl of 1 thru 3 carbon atoms or ##STR16## where R 3 is alkyl of 1 thru 4 carbon atoms or phenyl; where R 6 is a hydrogen atom or methyl group; where R 7 is a hydrogen atom or methyl group; where R 17 α is a hydrogen atom, alkyl of 1 thru 4 carbon atoms, alkenyl of 2 thru 4 carbon atoms or alkynyl of 2 thru 4 carbon atoms; where R 17 β is alkyl of 1 thru 16 carbon atoms, ##STR17## --(CH 2 ) n --CH(CH 2 ) m , --CH 2 --alkenyl where alkenyl is 2 thru 15 carbon atoms or --CH 2 --C═CH, and R 17 α and R 17 β can be connected to form a cyclic ether containing 4 or 5 carbon atoms; where Q is an oxygen atom; where X is a fluorine, chlorine or bromine atom; where Z is a hydrogen atom, alkyl of 1 thru 4 carbon atoms or ##STR18## that for the compounds of formula (XIV) the Z's may be the same or different; where m is 4 thru 6; where n is 0 thru 4; where p is 0 thru 4; where q is 1 or 2, when q is 2 the M's can be the same or different; where r is 1 or 2, when r is 2 the A's can be the same or different; where y is 1 or 2, when y is 2 the D's can be the same or different; where μ is 0 thru 4; where ˜ indicates the attached group can be in either the α or β configuration; and where is a single or double bond, if a single bond the hydrogen atom at C 5 is α; including the oximers and O-substituted oximes of compounds I thru IV and VI made with NH 2 --OR 3 to a male mammal post-puberty selected from the group consisting of man, male dog, tom, bull, stallion, ram, boar, male rat, and male mouse.

Claim 2

A method of effecting male contraception which comprises oral administration of a contraceptively effective amount of a comound of the formula: ##STR15## where A is a methyl, methoxy, trifluoromethyl, hydroxyl or nitro group or a hydrogen, fluorine, chlorine or bromine atom; where D is a methyl, methoxy, trifluoromethyl, hydroxyl or nitro group or a hydrogen, fluorine, chlorine or bromine atom; where M is a methyl, methoxy, trifluoromethyl, hydroxyl or nitro group or a hydrogen, fluorine, chlorine or bromine atom; where R 2 is a hydrogen atom or methyl group; where R 2 α is a hydrogen atom, alkyl 1 thru 4 carbon atoms or benzyl; where R 2 β is a hydrogen atom or methyl group with the proviso that when R 2 β is methyl, R 2 α is also methyl; where R 2 α is alkyl of 1 thru 3 carbon atoms or ##STR16## where R 3 is alkyl of 1 thru 4 carbon atoms or phenyl; where R 6 is a hydrogen atom or methyl group; where R 7 is a hydrogen atom or methyl group; where R 17 α is a hydrogen atom, alkyl of 1 thru 4 carbon atoms, alkenyl of 2 thru 4 carbon atoms or alkynyl of 2 thru 4 carbon atoms; where R 17 β is alkyl of 1 thru 16 carbon atoms, ##STR17## --(CH 2 ) n --CH(CH 2 ) m , --CH 2 --alkenyl where alkenyl is 2 thru 15 carbon atoms or --CH 2 --C═CH, and R 17 α and R 17 β can be connected to form a cyclic ether containing 4 or 5 carbon atoms; where Q is an oxygen atom; where X is a fluorine, chlorine or bromine atom; where Z is a hydrogen atom, alkyl of 1 thru 4 carbon atoms or ##STR18## that for the compounds of formula (XIV) the Z's may be the same or different; where m is 4 thru 6; where n is 0 thru 4; where p is 0 thru 4; where q is 1 or 2, when q is 2 the M's can be the same or different; where r is 1 or 2, when r is 2 the A's can be the same or different; where y is 1 or 2, when y is 2 the D's can be the same or different; where μ is 0 thru 4; where ˜ indicates the attached group can be in either the α or β configuration; and where is a single or double bond, if a single bond the hydrogen atom at C 5 is α; including the oximers and O-substituted oximes of compounds I thru IV and VI made with NH 2 --OR 3 to a male mammal post-puberty selected from the group consisting of man, male dog, tom, bull, stallion, ram, boar, male rat, and male mouse.