US4296110A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
Assignee: Bristol Myers Squibb Pharma Co
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Filing: 1980-10-28
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Granted: 1981-10-20
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Expires: 2000-10-28
Abstract
Abstract 1-Substituted cyclic lactam-2-carboxylic acids and their derivatives are useful as antihypertensive agents.
Inventors
- 👤 Alexander L. Johnson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 13:29
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; A; A61; A61P; A61P9/00; A61P9/12; C07D; C07D207/00; C07D207/02; C07D207/18; C07D207/22; C07D207/24; C07D207/26; C07D207/273; C07D207/277; C07D207/28; C07D211/00; C07D211/04; C07D211/68; C07D211/72; C07D211/78; C07D233/00; C07D233/04; C07D233/06; C07D233/08; C07D233/10; A61K; A61K38/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
124 words
A compound of the formula: ##STR100## where R and R 3 are independently OH, C 1 -C 4 alkoxy or benzyloxy; R 1 is H, CH 3 , C 2 H 5 , CF 3 , isobutyl, isoamyl, --(CH 2 ) n NHR 5 or ##STR101## R 2 is H or CH 3 ; R 4 is C 1 -C 10 alkyl, --(CH 2 ) q C 6 H 5 or --(CH 2 ) r NH 2 ; R 5 is H or C 1 -C 4 alkyl; m is 2, 3 or 4; n is an integer from 1-6; p is an integer from 1-6; q is an integer from 0-6; and r is an integer from 1-6; and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
124 words
A compound of the formula: ##STR100## where R and R 3 are independently OH, C 1 -C 4 alkoxy or benzyloxy; R 1 is H, CH 3 , C 2 H 5 , CF 3 , isobutyl, isoamyl, --(CH 2 ) n NHR 5 or ##STR101## R 2 is H or CH 3 ; R 4 is C 1 -C 10 alkyl, --(CH 2 ) q C 6 H 5 or --(CH 2 ) r NH 2 ; R 5 is H or C 1 -C 4 alkyl; m is 2, 3 or 4; n is an integer from 1-6; p is an integer from 1-6; q is an integer from 0-6; and r is an integer from 1-6; and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
9 words
A compound of claim 1 where R is OH.
Claim 4
Dependent Claim
19 words
A compound of claim 1 where R 1 is CH 3 or --(CH 2 ) 4 NH 2 .
Claim 5
Dependent Claim
10 words
A compound of claim 1 where R 2 is H.
Claim 6
Dependent Claim
18 words
A compound of claim 1 where R 3 is OH, OCH 3 or OC 2 H 5 .
Claim 7
Dependent Claim
25 words
A compound of claim 1 where R 4 is --CH 2 CH 2 C 6 H 5 or --(CH 2 ) 4 NH 2 .
Claim 8
Dependent Claim
18 words
A compound of claim 6 where R 4 is --CH 2 CH 2 C 6 H 5 .
Claim 9
Dependent Claim
57 words
A compound of claim 1 where R is OH, R 1 is CH 3 or --(CH 2 ) 4 NH 2 , R 2 is H, R 3 is OH, OCH 3 or OC 2 H 5 and R 4 is --CH 2 CH 2 C 6 H 5 or --(CH 2 ) 4 NH 2 .
Claim 10
Dependent Claim
18 words
A compound of claim 8 where R 4 is CH 2 CH 2 C 6 H 5 .
Claim 11
Dependent Claim
23 words
A pharmaceutical composition consisting essentially of a suitable pharmaceutical carrier and an effective hypertensive amount of a compound of claims 1 to 9.
Claim 12
Independent Claim
25 words
A method of treating hypertension in mammals which comprises administering to the mammal an effective hypertensive amount of a compound of claims 1 to 9.
References Cited (Backward Citations)
US4156789A
Cited
US4154937A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-19 | 1985-04-20 | 1985-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-19 | 1989-04-20 | 1989-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-19 | 1993-04-20 | 1993-10-20 | $7700.00 | Window Closed / Lapsed |