US4154937A
Expired / Lapsed
US
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Hydroxycarbamoylalkylacylpipecolic acid compounds
Assignee: ER Squibb and Sons LLC
•
Filing: 1978-06-26
•
Granted: 1979-05-15
•
Expires: 1998-06-26
Abstract
Abstract New hydroxycarbamoylalkylacyl derivatives of pipecolic acid which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
Inventors
- 👤 David W. Cushman
- 👤 Miguel A. Ondetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 14:38
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
48 words
A compound of the formula ##STR13## wherein R is hydroxy, amino or lower alkoxy; R 1 and R 4 each is hydrogen, lower alkyl or phenyl-lower alkyl; R 3 is hydrogen, hydroxy or lower alkyl; m is 3; n is 0, 1 or 2 and basic salts thereof.
Claim 2
Dependent Claim
48 words
A compound of the formula ##STR13## wherein R is hydroxy, amino or lower alkoxy; R 1 and R 4 each is hydrogen, lower alkyl or phenyl-lower alkyl; R 3 is hydrogen, hydroxy or lower alkyl; m is 3; n is 0, 1 or 2 and basic salts thereof.
Claim 3
Dependent Claim
31 words
A compound as in claim 1 wherein R is hydroxy; R 1 is hydrogen or lower alkyl; R 3 and R 4 each is hydrogen; and n is 1 or 2.
Claim 4
Dependent Claim
15 words
A compound as in claim 1 wherein R 3 and R 4 each is hydrogen.
Claim 5
Dependent Claim
10 words
A compound as in claim 1 wherein n is 1.
Claim 6
Dependent Claim
10 words
A compound as in claim 1 wherein n is 2.
Claim 7
Dependent Claim
10 words
A compound as in claim 1 wherein R is hydroxy.
Claim 8
Dependent Claim
13 words
A compound as in claim 1 wherein R 1 is hydrogen or methyl.
Claim 9
Dependent Claim
15 words
A compound as in claim 1 in which the pipecolic acid is in the L-form.
Claim 10
Dependent Claim
19 words
A compound as in claim 6 wherein R 1 is methyl, R 3 is hydrogen and n is 0.
Claim 11
Dependent Claim
23 words
A compound as in claim 6 wherein R 1 is methyl, R 3 and R 4 each is hydrogen and n is 1.
Claim 12
Dependent Claim
23 words
A compound as in claim 6 wherein R 1 is methyl, R 3 and R 4 each is hydrogen and n is 2.
Claim 13
Dependent Claim
23 words
A compound as in claim 6 wherein R 1 is methyl, R 3 is 5-hydroxy, R 4 is hydrogen and n is 1.
Claim 14
Dependent Claim
23 words
A compound as in claim 6 wherein R 1 is methyl, R 3 is 5-hydroxy, R 4 is hydrogen and n is 2.
References Cited (Backward Citations)
US3337548A
Cited
US4046889A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-14 | 1982-11-13 | 1983-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-14 | 1986-11-13 | 1987-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-14 | 1990-11-13 | 1991-05-15 | $7700.00 | Window Closed / Lapsed |