Patent US3343553A successfully refreshed from Google Patents.
Patent US4295280A successfully refreshed from Google Patents.
US4295280A
Expired / Lapsed
US
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Method of obtaining a lyophilized product
Assignee: Wyeth LLC
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Filing: 1980-03-17
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Granted: 1981-10-20
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Expires: 2000-03-17
Abstract
Abstract A mixture of at least two liquid compositions, each having a material which is incompatible in the presence of moisture with a material in the other liquid composition, is cooled to a temperature slightly above its freezing point. The cooled mixture is charged into a container cooled substantially below the freezing point of the mixture so the mixture freezes instantly. The frozen mixture is lyophilized to provide a mass of dry matter.
Inventors
- 👤 John Krupey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:01
CPC Classifications
F; F26; F26B; F26B5/00; F26B5/04; F26B5/06
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
116 words
A process for obtaining a package containing a mass of dry material comprising at least two immunologic reagent materials incompatible with each other in the presence of moisture comprising the steps of: (a) preparing separate aqueous liquid compositions of each of the materials; (b) cooling each of the liquid compositions to a temperature slightly above its freezing point; (c) mixing the cooled liquid compositions to obtain a mixture thereof; (d) charging the mixture of liquid compositions at a temperature slightly above the freezing point of the mixture into a container maintained at a temperature substantially below the freezing point of the mixture so that the mixture freezes in the container; and (e) lyophilizing the frozen mixture.
Claim 2
Dependent Claim
116 words
A process for obtaining a package containing a mass of dry material comprising at least two immunologic reagent materials incompatible with each other in the presence of moisture comprising the steps of: (a) preparing separate aqueous liquid compositions of each of the materials; (b) cooling each of the liquid compositions to a temperature slightly above its freezing point; (c) mixing the cooled liquid compositions to obtain a mixture thereof; (d) charging the mixture of liquid compositions at a temperature slightly above the freezing point of the mixture into a container maintained at a temperature substantially below the freezing point of the mixture so that the mixture freezes in the container; and (e) lyophilizing the frozen mixture.
Claim 3
Dependent Claim
50 words
The process of claim 1 wherein each of the liquid compositions is cooled to a temperature of about 1° to 5° C. above its freezing point and the mixture is charged at a temperature of about 1° to 5° C. above the freezing point of the mixture into the container.
Claim 4
Dependent Claim
28 words
The process of claim 1 wherein one liquid composition consists essentially of a predetermined immunologically effective amount of a suspension of sheep erythrocytes sensitized with human chorionic gonadotropin.
Claim 5
Dependent Claim
27 words
The process of claim 3 wherein a second liquid composition consists essentially of a predetermined immunologically effective amount of human chorionic gonadotropin antiserum together with phosphate buffer.
Claim 6
Dependent Claim
24 words
The process of claim 2 or 4 wherein the simultaneous charging of the liquid compositions is directed to the bottom of the upright container.
Claim 7
Dependent Claim
12 words
The process of claim 5 wherein the container is a shallow container.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-19 | 1985-04-20 | 1985-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-19 | 1989-04-20 | 1989-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-19 | 1993-04-20 | 1993-10-20 | $7700.00 | Window Closed / Lapsed |