Patent US4293436A successfully refreshed from Google Patents.
US4293436A
Expired / Lapsed
US
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Autofluorogram and composition and method for making the same
Assignee: Revvity Health Sciences Inc
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Filing: 1979-03-30
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Granted: 1981-10-06
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Expires: 1999-03-30
Abstract
Abstract An improved method of enhancing the effect of weak, e.g. beta, radioactive emitters, such as tritium and carbon-14, on film by contacting the medium used to contain the radioactive emitter with a fluor dissolved or dispersed in a carboxylic acid. A new composition of matter for performing such a method, comprising a fluor dissolved or dispersed in a carboxylic acid. An article of manufacture comprising an aqueous separation medium impregnated with a fluor and a solvent.
Inventors
- 👤 Dennis L. Fost
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 12:40
CPC Classifications
G; G01; G01T; G01T1/00; G01T1/16; G01T1/20; G01T1/204; G01T1/2042; G01T1/29; G01T1/2914; G01T1/2921; G01T1/2942; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/107497; Y10T436/14; Y10T436/142222; Y10T436/143333
Claims Analysis
Total Claims: 41
Claim 1
Independent Claim
48 words
A method of impregnating an autofluorographic medium for use in an autofluorographic method comprising impregnating an absorbent or adsorbent autofluorographic medium with at least 0.01% by weight of a fluor in a solution having between 47.5 and 95% by weight of a water-soluble or water-miscible carboxylic acid carrier.
Claim 2
Independent Claim
48 words
A method of impregnating an autofluorographic medium for use in an autofluorographic method comprising impregnating an absorbent or adsorbent autofluorographic medium with at least 0.01% by weight of a fluor in a solution having between 47.5 and 95% by weight of a water-soluble or water-miscible carboxylic acid carrier.
Claim 3
Independent Claim
66 words
A method of enhancing the autofluorographic effect on film of radioactive emitters contained within an absorbent or adsorbent medium comprising contacting said medium with a mixture comprising at least 0.01% by weight of a fluor dissolved or dispersed in between 47.5 and 95% by weight of a water-soluble or water-miscible carboxylic acid to disperse said fluor throughout said medium, and precipitating said fluor within said medium.
Claim 4
Independent Claim
66 words
A method of enhancing the autofluorographic effect on film of radioactive emitters contained within an absorbent or adsorbent medium comprising contacting said medium with a mixture comprising at least 0.01% by weight of a fluor dissolved or dispersed in between 47.5 and 95% by weight of a water-soluble or water-miscible carboxylic acid to disperse said fluor throughout said medium, and precipitating said fluor within said medium.
Claim 5
Dependent Claim
26 words
The method of claim 2 in which said medium is contacted with said fluor in said carboxylic acid for a period of less than three hours.
Claim 6
Dependent Claim
16 words
The method of claim 2 in which said carboxylic acid is a lower alkyl carboxylic acid.
Claim 7
Dependent Claim
13 words
The method of claim 2, in which said carboxylic acid is acetic acid.
Claim 8
Dependent Claim
22 words
The method of claim 2 in which said fluor is present in a concentration between about 0.05% and about 20% by weight.
Claim 9
Dependent Claim
11 words
The method of claim 2 in which said fluor is 2,5-diphenyloxazole.
Claim 10
Dependent Claim
19 words
The method of claim 2, wherein said mixture further includes, at least 0.01% by weight of a scintillation solvent.
Claim 11
Dependent Claim
11 words
The method of claim 8 in which said solvent is 2-methylnaphthalene.
Claim 12
Dependent Claim
22 words
The method of claim 8 in which said solvent is present in a concentration between about 0.1% and about 20% by weight.
Claim 13
Dependent Claim
42 words
The method of claim 8 in which the fluor and solvent are present in combination in a concentration between about 0.1% and about 20% by weight, and the ratio of said solvent to said fluor is from about 10:1 to about 50:1.
Claim 14
Dependent Claim
27 words
The method of claim 2 or 8 wherein said mixture further includes a swelling inhibitor in a concentration sufficient to reduce swelling or shrinking of said medium.
Claim 15
Dependent Claim
23 words
The method of claim 12 in which said swelling inhibitor is present in a concentration between about 1% and about 47.5% by weight.
Claim 16
Dependent Claim
12 words
The method of claim 12 in which said swelling inhibitor is 2-ethoxyethanol.
Claim 17
Independent Claim
16 words
The method of claims 1 or 2 in which said medium is a solid aqueous medium.
Claim 18
Dependent Claim
16 words
The method of claim 15 in which said aqueous medium is agarose, polyacrylamide, or agarose-polyacrylamide gel.
Claim 19
Dependent Claim
31 words
A composition of matter comprising at least 0.01% by weight of a fluor in a solution having between 47.5 and 95% by weight of a water-soluble or water-miscible carboxylic acid carrier.
Claim 20
Dependent Claim
31 words
A composition of matter comprising at least 0.01% by weight of a fluor in a solution having between 47.5 and 95% by weight of a water-soluble or water-miscible carboxylic acid carrier.
Claim 21
Dependent Claim
16 words
The composition of claim 17 in which said carboxylic acid is a lower alkyl carboxylic acid.
Claim 22
Dependent Claim
13 words
The composition of claim 17 in which said carboxylic acid is acetic acid.
Claim 23
Dependent Claim
22 words
The composition of claim 17 in which said fluor is present in a concentration between about 0.05% and about 20% by weight.
Claim 24
Dependent Claim
11 words
The composition of claim 17 in which said fluor is 2,5-diphenyloxazole.
Claim 25
Dependent Claim
17 words
The composition of claim 17 including in addition, at least 0.01% by weight of a scintillation solvent.
Claim 26
Dependent Claim
11 words
The composition of claim 22 in which said solvent is 2-methylnaphthalene.
Claim 27
Dependent Claim
22 words
The composition of claim 22 in which said solvent is present in a concentration between about 0.1% and about 20% by weight.
Claim 28
Dependent Claim
43 words
The composition of claim 22 in which said fluor and said solvent are present in combination in a concentration between about 0.1% and about 20% by weight, and the ratio of said solvent to said fluor is from about 10:1 to about 50:1.
Claim 29
Dependent Claim
32 words
The composition of one of claims 17 to 22 including in addition a swelling inhibitor in a concentration sufficient to prevent an absorbent or adsorbent autofluorographic medium from significantly swelling or shrinking.
Claim 30
Dependent Claim
23 words
The composition of claim 26 in which said swelling inhibitor is present in a concentration between about 1% and about 47.5% by weight.
Claim 31
Dependent Claim
12 words
The composition of claim 26 in which said swelling inhibitor is 2-ethoxyethanol.
Claim 32
Dependent Claim
20 words
An autofluorogram comprising an absorbent solid aqueous separation medium impregnated with the composition of one of claim 17 or 22.
Claim 33
Dependent Claim
16 words
The autofluorogram of claim 29 in which said medium is a polyacrylamide, agarose, or agarose-polyacrylamide gel.
Claim 34
Dependent Claim
18 words
The autofluorogram of claim 29 in which said medium contains less than about 5% by weight of fluor.
Claim 35
Dependent Claim
19 words
A radioactive labelled animal or plant tissue impregnated with the composition of one of claims 17, 22, or 26.
Claim 36
Dependent Claim
21 words
An article of manufacture comprising a solid aqueous separation medium impregnated with the composition of one of claims 17 or 22.
Claim 37
Dependent Claim
16 words
The article of claim 33 in which said medium is a polyacrylamide, agarose, or agarose-polyacrylamide gel.
Claim 38
Dependent Claim
18 words
The article of claim 33 in which said medium contains less than about 5% by weight of fluor.
Claim 39
Dependent Claim
16 words
An autofluorogram comprising an absorbent solid aqueous separation medium impregnated with the composition of claim 26.
Claim 40
Dependent Claim
13 words
A radioactive labelled animal or plant tissue impregnated with the composition claim 26.
Claim 41
Dependent Claim
17 words
An article of manufacture comprising a solid aqueous separation medium impregnated with the composition of claim 26.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-05 | 1985-04-06 | 1985-10-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-05 | 1989-04-06 | 1989-10-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-05 | 1993-04-06 | 1993-10-06 | $7700.00 | Window Closed / Lapsed |