Patent US4292920A successfully refreshed from Google Patents.
US4292920A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Magnetic attraction transfer devices for use in solid phase radioimmunoassays and in other assay methods
Assignee: Individual
•
Filing: 1979-12-20
•
Granted: 1981-10-06
•
Expires: 1999-12-20
Abstract
Abstract A device for transferring, by magnetic attraction, antigen-antibody adsorbent materials from one reaction mixture to another, and to facilitate an efficient rinsing of these materials, and for transferring adsorbent materials used in other assay methods.
Inventors
- 👤 Kendall O. Smith
- 👤 Warren D. Gehle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 09:35
CPC Classifications
B; B03; B03C; B03C1/00; B03C1/02; B03C1/025; B03C1/031; B03C1/033; B03C1/0332; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54313; G01N33/54326; G01N35/00; G01N35/0098
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
181 words
A device for use in solid phase immumoassays, for simultaneously transferring a plurality of antigen-antibody absorbent units from one location to another, comprising a transfer element in combination with a tray of non-magnetic material having a plurality of spaced receptacles therein for containing an appropriate liquid and for containing units each comprising a core of ferromagnetic material, each said core being covered with at least one coating for preventing chemical interactions between said core and aqueous chemical solutions and for absorbing antigens or antibodies on the outer surface thereof, said transfer element having a first portion of ferromagnetic material overlying said spaced receptacles in a transfer condition of said element, and said element having a second portion of non-magnetic material overlying spaces between said receptacles when in said transfer condition, and one of said ferromagnetic core and transfer device materials having magnetic properties to effect a magnetic attraction between said units and said transfer device, whereby said units are removable from said receptacles by magnetic attraction while being maintained in spaced apart relationship by said non-magnetic material during said transfer condition.
Claim 2
Independent Claim
181 words
A device for use in solid phase immumoassays, for simultaneously transferring a plurality of antigen-antibody absorbent units from one location to another, comprising a transfer element in combination with a tray of non-magnetic material having a plurality of spaced receptacles therein for containing an appropriate liquid and for containing units each comprising a core of ferromagnetic material, each said core being covered with at least one coating for preventing chemical interactions between said core and aqueous chemical solutions and for absorbing antigens or antibodies on the outer surface thereof, said transfer element having a first portion of ferromagnetic material overlying said spaced receptacles in a transfer condition of said element, and said element having a second portion of non-magnetic material overlying spaces between said receptacles when in said transfer condition, and one of said ferromagnetic core and transfer device materials having magnetic properties to effect a magnetic attraction between said units and said transfer device, whereby said units are removable from said receptacles by magnetic attraction while being maintained in spaced apart relationship by said non-magnetic material during said transfer condition.
Claim 3
Dependent Claim
25 words
The device according to claim 1, wherein cooperating means are provided on said tray and on said transfer element for effecting said aligned condition therebetween.
Claim 4
Dependent Claim
27 words
The device according to claim 1, wherein said ferromagnetic material of said transfer element comprise a plurality of ferromagnetic elements spatially oriented relative to said spaced receptacles.
Claim 5
Independent Claim
43 words
The device according to claims 1, 2 or 3, wherein each said unit has an inner coating for preventing chemical interactions between said core and the aqueous chemical solutions and an exterior coating for adsorbing antigens or antibodies on said outer surface thereof.
Claim 6
Dependent Claim
29 words
The device according to claim 4, wherein said exterior coating comprises an adsorbing coat selected from the group consisting of polycarbonate, polyethylene, polystyrene, polypropylene, acrylics, glass and chromatographic substances.
Claim 7
Dependent Claim
41 words
The device according to claim 4, wherein said inner coating includes a stable metal selected from the group consisting of nickel, gold, zinc, chromium, cadmium and copper, for effectively sealing said core from penetration and chemical interaction with aqueous chemical solutions.
Claim 8
Dependent Claim
29 words
The device according to claim 6, wherein said exterior coating comprises an adsorbing coat selected from the group consisting of polycarbonate, polyethylene, polystyrene, polypropylene, acrylics, glass and chromatographic substances.
Claim 9
Dependent Claim
29 words
The device according to claim 4, wherein said inner coating comprises waterproof paint material for effectively sealing said core from penetration and chemical interaction with the aqueous chemical solutions.
Claim 10
Dependent Claim
28 words
The device according to claim 8, wherein said exterior comprises an adsorbing coat selected from the group consisting of polycarbonate, polyethylene polystyrene, polypropylene, acrylics, glass and chromatographic substances.
Claim 11
Independent Claim
57 words
The device according to claims 1, 2, or 3, wherein said transfer element is at least partially coated with a material capable of reducing or preventing adsorption of antibodies or antigens to its surface and of preventing degradation of said non-magnetic material of said transfer element during exposure to aqueous chemical solutions used in solid phase immunoassays.
Claim 12
Dependent Claim
20 words
The device according to claim 3, wherein said ferromagnetic elements are disposed flush with a surface of said transfer element.
Claim 13
Dependent Claim
48 words
The device according to claim 3, wherein said ferromagnetic elements extend outwardly of a surface of said transfer element, and a release member of non-magnetic material surrounding said ferromagnetic elements is provided for releasing said units adhering thereto by movement of said release member away from said surface.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-05 | 1985-04-06 | 1985-10-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-05 | 1989-04-06 | 1989-10-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-05 | 1993-04-06 | 1993-10-06 | $7700.00 | Window Closed / Lapsed |