US4291133A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nonthrombogenic polymer surface
Assignee: University of Utah Research Foundation Inc
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Filing: 1979-04-05
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Granted: 1981-09-22
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Expires: 1999-04-05
Abstract
Abstract Polymer surfaces which are rendered nonthrombogenic are disclosed. Polymers, including hydrophobic polymers, which can be swollen by selected solvents, are rendered nonthrombogenic by absorbing into the surface of said polymers pendant aliphatic side chains which are attached to a linear polymer having reactive pendant groups which are negatively charged or which may be reacted with compounds having a negative charge, such as heparin. The compounds absorbed into the substrate surface have multi-point attachment to the surface.
Inventors
- 👤 Vaclav Horak
- 👤 Jiri Janata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:18
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; C; C08; C08J; C08J7/00; C08J7/04; C08J7/0427; C08J7/056; H; H05; H05K; H05K3/00; H05K3/10; H05K3/18; H05K3/181; H05K3/38; H05K3/381; Y; Y10; Y10T; Y10T428/00; Y10T428/31504; Y10T428/31855; Y10T428/31909
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
79 words
A surface-modified polymeric substrate comprising: a polymeric hydrophobic substrate swellable by selected solvents: and a branched-chain polymer having a substantially linear hydrocarbon backbone, substantially linear hydrocarbon aliphatic side chains spaced along said backbone and a plurality of pendant reactive groups which are negatively charged or which may be reacted with compounds having a negative charge depending from said backbone, said linear aliphatic side chains having not over twenty (20) carbon atoms and being substantially embedded in said polymeric substrate.
Claim 2
Dependent Claim
79 words
A surface-modified polymeric substrate comprising: a polymeric hydrophobic substrate swellable by selected solvents: and a branched-chain polymer having a substantially linear hydrocarbon backbone, substantially linear hydrocarbon aliphatic side chains spaced along said backbone and a plurality of pendant reactive groups which are negatively charged or which may be reacted with compounds having a negative charge depending from said backbone, said linear aliphatic side chains having not over twenty (20) carbon atoms and being substantially embedded in said polymeric substrate.
Claim 3
Dependent Claim
21 words
The surface-modified hydrophobic polymeric substrate of claim 1 wherein said linear aliphatic chains each have at least about five carbon atoms.
Claim 4
Dependent Claim
20 words
The surface-modified hydrophobic polymeric substrate of claim 1 wherein said branched chain polymer has at least about five aliphatic chains.
Claim 5
Dependent Claim
22 words
The surface-modified hydrophobic polymeric substrate of claim 1 wherein said branched chain polymer has aliphatic chains substantially regularly spaced from one another.
Claim 6
Dependent Claim
28 words
The surface-modified hydrophobic polymeric substrate of claim 1 wherein said branched chain polymer has aliphatic chains which are spaced on the polymer backbone by at least two atoms.
Claim 7
Dependent Claim
16 words
The surface-modified hydrophobic polymeric substrate of claim 1 wherein said reactive groups have a negative charge.
Claim 8
Dependent Claim
16 words
The surface-modified hydrophobic polymeric substrate of claim 1 wherein said reactive groups are reactive with heparin.
Claim 9
Dependent Claim
20 words
The surface-modified hydrophobic polymeric substrate of claim 1 wherein said branched chain polymer has at least about ten aliphatic chains.
Claim 10
Dependent Claim
21 words
The surface-modified hydrophobic polymeric substrate of claim 1 wherein said aliphatic pendant chains each have at least about ten carbon atoms.
Claim 11
Dependent Claim
22 words
The surface-modified hydrophobic polymeric substrate of claim 1 wherein said linear aliphatic pendant chains are substantially completely embedded in the polymeric substrate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-21 | 1985-03-23 | 1985-09-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-21 | 1989-03-23 | 1989-09-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-21 | 1993-03-23 | 1993-09-22 | $7700.00 | Window Closed / Lapsed |