Patent US4290965A successfully refreshed from Google Patents.
US4290965A
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Method of making 1123 labeled fatty acids
Assignee: Forschungszentrum Jülich
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Filing: 1980-04-03
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Granted: 1981-09-22
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Expires: 2000-04-03
Abstract
Abstract A procedure for making ω-I 123 labeled fatty acids in which the ω-bromo-fatty acid is applied in a thin film or layer to a support and is there contacted in molten state with the I 123 iodide to effect halogen exchange.
Inventors
- 👤 Gerhard Stocklin
- 👤 Peter Laufer
- 👤 Jurgen Machulla
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 19:19
CPC Classifications
C; C07; C07B; C07B59/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
77 words
A method of making a ω-I 123 labeled fatty acid which comprises the steps of: (a) applying a thin layer of an ω-bromo-fatty acid to an inert support; (b) contacting said layer on said support with an I 123 containing iodide; and (c) heating said layer on said support in contact with said I 123 iodide to a temperature sufficient to effect halogen substitution whereby said ω-bromo-fatty acid is converted into the corresponding ω-I 123 -fatty acid.
Claim 2
Independent Claim
77 words
A method of making a ω-I 123 labeled fatty acid which comprises the steps of: (a) applying a thin layer of an ω-bromo-fatty acid to an inert support; (b) contacting said layer on said support with an I 123 containing iodide; and (c) heating said layer on said support in contact with said I 123 iodide to a temperature sufficient to effect halogen substitution whereby said ω-bromo-fatty acid is converted into the corresponding ω-I 123 -fatty acid.
Claim 3
Dependent Claim
24 words
The method defined in claim 1 wherein the reaction in step (c) is carried out for a period of 2 to about 10 minutes.
Claim 4
Dependent Claim
19 words
The method defined in claim 2 wherein said ω-bromo-fatty acid is a C 16 to C 18 fatty acid.
Claim 5
Dependent Claim
38 words
The method defined in claim 3, further comprising the step of dissolving the product of the reaction in step (c) directly from said support and subjecting the resulting solution to chromatography to recover said ω-I 123 -fatty acid.
Claim 6
Dependent Claim
83 words
The method defined in claim 1, claim 2, claim 3 or claim 4, wherein the reaction product formed in step (c) is subjected to high-pressure liquid chromatography by dissolving the reaction product in the eluent and passing same through a high-pressure liquid chromatography column, said column consisting of silica gel which is eluted with a nonpolar eluent containing a dissolved polar component, or silica gel to which an alkane or an alkylamine is bonded and which is eluted with a polar protic eluent.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-21 | 1985-03-23 | 1985-09-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-21 | 1989-03-23 | 1989-09-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-21 | 1993-03-23 | 1993-09-22 | $7700.00 | Window Closed / Lapsed |